Forward-scattering degenerate four-wave mixing as a potential laser-based absorption detection method in liquid separation systems: coupling to conventional-size liquid chromatography.

T. de Beer, G.Ph. Hoornweg, G.J. Grootendorst, N.H. Velthorst, C. Gooijer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

An explorative study on the compatibility of liquid separation systems, such as (micro) liquid chromatography (LC) and capillary electrophoresis (CE), and forward-scattering degenerate four-wave mixing (F-D4WM) as a detection method is presented. F-D4WM is a laser-based technique showing some analogy with holographic spectroscopy: a signal on a theoretical dark background is observed as a result of light absorption by an analyte. Parameters considered are solvent composition (focussing on acetonitrile, methanol and water; mobile phases in LC and CE), detector cell construction, and influences of laser beam powers. A specially designed detector cell has been developed to meet the Brewster condition, both at the air-quartz and the quartz-liquid boundaries. For practical reasons, the tested cell has an optical pathlength of 1 mm; reduction to 100 μm is required to apply the cell in microseparations. The F-D4WM technique has been involved for detection in a conventional-size, reversed-phase LC separation of 1- and 2-aminoanthraquinones. The detection limit obtained (for the 1 mm cell) is 2 x 10
Original languageEnglish
Pages (from-to)189-197
JournalAnalytica Chimica Acta
Volume330
DOIs
Publication statusPublished - 1996

Fingerprint

Forward scattering
Four wave mixing
Liquid chromatography
detection method
Liquid Chromatography
liquid chromatography
Capillary electrophoresis
Quartz
Lasers
laser
scattering
liquid
electrokinesis
Liquids
quartz
Detectors
Capillary Electrophoresis
Light absorption
Laser beams
Methanol

Cite this

@article{ba8bb33df7ef4f07b2675b53de029274,
title = "Forward-scattering degenerate four-wave mixing as a potential laser-based absorption detection method in liquid separation systems: coupling to conventional-size liquid chromatography.",
abstract = "An explorative study on the compatibility of liquid separation systems, such as (micro) liquid chromatography (LC) and capillary electrophoresis (CE), and forward-scattering degenerate four-wave mixing (F-D4WM) as a detection method is presented. F-D4WM is a laser-based technique showing some analogy with holographic spectroscopy: a signal on a theoretical dark background is observed as a result of light absorption by an analyte. Parameters considered are solvent composition (focussing on acetonitrile, methanol and water; mobile phases in LC and CE), detector cell construction, and influences of laser beam powers. A specially designed detector cell has been developed to meet the Brewster condition, both at the air-quartz and the quartz-liquid boundaries. For practical reasons, the tested cell has an optical pathlength of 1 mm; reduction to 100 μm is required to apply the cell in microseparations. The F-D4WM technique has been involved for detection in a conventional-size, reversed-phase LC separation of 1- and 2-aminoanthraquinones. The detection limit obtained (for the 1 mm cell) is 2 x 10",
author = "{de Beer}, T. and G.Ph. Hoornweg and G.J. Grootendorst and N.H. Velthorst and C. Gooijer",
year = "1996",
doi = "10.1016/0003-2670(96)00170-5",
language = "English",
volume = "330",
pages = "189--197",
journal = "Analytica Chimica Acta",
issn = "0003-2670",
publisher = "Elsevier",

}

Forward-scattering degenerate four-wave mixing as a potential laser-based absorption detection method in liquid separation systems: coupling to conventional-size liquid chromatography. / de Beer, T.; Hoornweg, G.Ph.; Grootendorst, G.J.; Velthorst, N.H.; Gooijer, C.

In: Analytica Chimica Acta, Vol. 330, 1996, p. 189-197.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Forward-scattering degenerate four-wave mixing as a potential laser-based absorption detection method in liquid separation systems: coupling to conventional-size liquid chromatography.

AU - de Beer, T.

AU - Hoornweg, G.Ph.

AU - Grootendorst, G.J.

AU - Velthorst, N.H.

AU - Gooijer, C.

PY - 1996

Y1 - 1996

N2 - An explorative study on the compatibility of liquid separation systems, such as (micro) liquid chromatography (LC) and capillary electrophoresis (CE), and forward-scattering degenerate four-wave mixing (F-D4WM) as a detection method is presented. F-D4WM is a laser-based technique showing some analogy with holographic spectroscopy: a signal on a theoretical dark background is observed as a result of light absorption by an analyte. Parameters considered are solvent composition (focussing on acetonitrile, methanol and water; mobile phases in LC and CE), detector cell construction, and influences of laser beam powers. A specially designed detector cell has been developed to meet the Brewster condition, both at the air-quartz and the quartz-liquid boundaries. For practical reasons, the tested cell has an optical pathlength of 1 mm; reduction to 100 μm is required to apply the cell in microseparations. The F-D4WM technique has been involved for detection in a conventional-size, reversed-phase LC separation of 1- and 2-aminoanthraquinones. The detection limit obtained (for the 1 mm cell) is 2 x 10

AB - An explorative study on the compatibility of liquid separation systems, such as (micro) liquid chromatography (LC) and capillary electrophoresis (CE), and forward-scattering degenerate four-wave mixing (F-D4WM) as a detection method is presented. F-D4WM is a laser-based technique showing some analogy with holographic spectroscopy: a signal on a theoretical dark background is observed as a result of light absorption by an analyte. Parameters considered are solvent composition (focussing on acetonitrile, methanol and water; mobile phases in LC and CE), detector cell construction, and influences of laser beam powers. A specially designed detector cell has been developed to meet the Brewster condition, both at the air-quartz and the quartz-liquid boundaries. For practical reasons, the tested cell has an optical pathlength of 1 mm; reduction to 100 μm is required to apply the cell in microseparations. The F-D4WM technique has been involved for detection in a conventional-size, reversed-phase LC separation of 1- and 2-aminoanthraquinones. The detection limit obtained (for the 1 mm cell) is 2 x 10

U2 - 10.1016/0003-2670(96)00170-5

DO - 10.1016/0003-2670(96)00170-5

M3 - Article

VL - 330

SP - 189

EP - 197

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

SN - 0003-2670

ER -