TY - JOUR
T1 - Forward- scattering degenerate four-wave mixing for sensitive absorption detection in microseparation systems. Coupling to micro-column liquid chromatography.
AU - de Beer, T.
AU - Termaten, A.T.
AU - Brinkman, U.A.T.
AU - Hoornweg, G.Ph.
PY - 1998
Y1 - 1998
N2 - The feasibility of forward-scattering degenerate four-wave mixing (F- D4WM) for detection in micro-column (internal diameter 0.3 mm) liquid chromatography (micro-LC) is studied, using the separation of 1-amino-9,10- anthraquinone (I-AAQ) and 2-amino-9,10-anthraquinone (II-AAQ) as a model system and utilizing the 514 nm line of an argon-ion laser. Though the F- D4WM signal can be detected on a virtually dark background, in practice background reduction is of utmost importance. Background reduction by means of a mechanical chopper and a scanning confocal Fabry-Perot interferometer (CFP) are compared both experimentally and theoretically. Using the CFP set- up, an injected concentration limit of detection of 3.10
AB - The feasibility of forward-scattering degenerate four-wave mixing (F- D4WM) for detection in micro-column (internal diameter 0.3 mm) liquid chromatography (micro-LC) is studied, using the separation of 1-amino-9,10- anthraquinone (I-AAQ) and 2-amino-9,10-anthraquinone (II-AAQ) as a model system and utilizing the 514 nm line of an argon-ion laser. Though the F- D4WM signal can be detected on a virtually dark background, in practice background reduction is of utmost importance. Background reduction by means of a mechanical chopper and a scanning confocal Fabry-Perot interferometer (CFP) are compared both experimentally and theoretically. Using the CFP set- up, an injected concentration limit of detection of 3.10
U2 - 10.1016/S0021-9673(98)00258-1
DO - 10.1016/S0021-9673(98)00258-1
M3 - Article
SN - 0021-9673
VL - 811
SP - 35
EP - 45
JO - Journal of Chromatography A
JF - Journal of Chromatography A
ER -
