TY - JOUR
T1 - Fragment-based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase
AU - van Linden, O.P.J.
AU - Farenc, C
AU - Zoutman, W.H.
AU - Hameetman, L
AU - Wijtmans, M.
AU - Leurs, R.
AU - Tensen, C.P.
AU - Siegal, G.
AU - de Esch, I.J.P.
PY - 2011
Y1 - 2011
N2 - The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially available compounds was subjected to an in silico screening procedure which was focused on finding novel, EPHA4 hinge binding fragments. This resulted in the identification of 6,7,8,9-tetrahydro-3H- pyrazolo[3,4-c]isoquinolin-1-amine derivatives as EPHA4 inhibitors. Hit exploration yielded a compound with 2 μM (IC
AB - The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially available compounds was subjected to an in silico screening procedure which was focused on finding novel, EPHA4 hinge binding fragments. This resulted in the identification of 6,7,8,9-tetrahydro-3H- pyrazolo[3,4-c]isoquinolin-1-amine derivatives as EPHA4 inhibitors. Hit exploration yielded a compound with 2 μM (IC
U2 - 10.1016/j.ejmech.2011.11.020
DO - 10.1016/j.ejmech.2011.11.020
M3 - Article
SN - 0223-5234
VL - 47
SP - 493
EP - 500
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -
