Fragment library design: efficiently hunting drugs in chemical space

With the growth in fragment-based drug discovery, numerous strategies have been described for the design of fragment libraries. Key choices need to be made on both the selection criteria to be applied and the source of the fragments in the library. Here we review some of the key trends and recent developments in the rapidly evolving field of fragment library design, providing an overview of current design strategies and surveying the characteristics of published fragment libraries. © 2010 Published by Elsevier Ltd.