Fragment library design: efficiently hunting drugs in chemical space

S.M. Boyd, G.E. de Kloe

Research output: Contribution to JournalArticleAcademicpeer-review


With the growth in fragment-based drug discovery, numerous strategies have been described for the design of fragment libraries. Key choices need to be made on both the selection criteria to be applied and the source of the fragments in the library. Here we review some of the key trends and recent developments in the rapidly evolving field of fragment library design, providing an overview of current design strategies and surveying the characteristics of published fragment libraries. © 2010 Published by Elsevier Ltd.
Original languageEnglish
Pages (from-to)173-180
Number of pages55
JournalDrug Discovery Today
Issue number3
Publication statusPublished - 2010


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