TY - JOUR
T1 - Fragment-to-Lead Medicinal Chemistry Publications in 2023
AU - Holvey, Rhian S.
AU - Erlanson, Daniel A.
AU - de Esch, Iwan J.P.
AU - Farkaš, Barbara
AU - Jahnke, Wolfgang
AU - Nishiyama, Tsuyoshi
AU - Woodhead, Andrew J.
N1 - Publisher Copyright:
© 2025 American Chemical Society.
PY - 2025/1/6
Y1 - 2025/1/6
N2 - This Perspective summarizes successful fragment-to-lead (F2L) studies that were published in 2023 and is the ninth installment in an annual series. A tabulated summary of the relevant articles published in 2023 is provided (17 entries from 16 articles), and a comparison of the target classes, screening methods, and overall fragment or lead property trends for 2023 examples and for the combined entries over the years 2015-2023 is discussed. In addition, we identify several trends and innovations in the 2023 literature that promise to further increase the success of fragment-based drug discovery (FBDD), particularly in the areas of NMR and virtual screening, fragment library design, and fragment linking.
AB - This Perspective summarizes successful fragment-to-lead (F2L) studies that were published in 2023 and is the ninth installment in an annual series. A tabulated summary of the relevant articles published in 2023 is provided (17 entries from 16 articles), and a comparison of the target classes, screening methods, and overall fragment or lead property trends for 2023 examples and for the combined entries over the years 2015-2023 is discussed. In addition, we identify several trends and innovations in the 2023 literature that promise to further increase the success of fragment-based drug discovery (FBDD), particularly in the areas of NMR and virtual screening, fragment library design, and fragment linking.
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U2 - 10.1021/acs.jmedchem.4c02593
DO - 10.1021/acs.jmedchem.4c02593
M3 - Review article
AN - SCOPUS:85214369214
SN - 0022-2623
VL - 68
SP - 986
EP - 1001
JO - Journal of medicinal chemistry
JF - Journal of medicinal chemistry
IS - 2
ER -