Frailty in older adults with cardiovascular disease: Cause, effect or both?

Emma E.F. Kleipool, Emiel O. Hoogendijk, Marijke C. Trappenburg, M. Louis Handoko, Martijn Huisman, Mike J.L. Peters, Majon Muller

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Cardiovascular disease (CVD) has been associated with an increased risk of frailty, but the direction of the association remains unclear. This study set out to examine the bidirectional longitudinal association between CVD and frailty over an extended period of time. Data are from 1432 older adults (aged 65-88yrs) of the Longitudinal Aging Study Amsterdam (LASA), who were followed for 17 years. At baseline and follow-up, CVD was assessed through self-report, medication use and medical records, and classified as angina pectoris, myocardial infarction, heart failure (HF), stroke, and peripheral artery disease. Throughout the study, frailty was assessed using Fried's frailty criteria. Cox regression models showed that patients with HF had an increased frailty risk (HR 2.7; 95%CI: 1.5-5.1) after a median follow-up of 8.4 yrs. This finding was independent of potential confounders (age, sex, several comorbidities). Examinations of the reverse association revealed that frail older adults were not at risk of incident CVD. Of all older adults with CVD, those with HF have an increased risk of frailty and frail older adults do not have an increased risk of CVD. Our findings emphasize the need for cardiac rehabilitation programs evaluating the effect of physical exercise programs in order to prevent frailty and therewith improve quality of life and independence of care in CVD patients.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalAging and Disease
Volume9
Issue number3
DOIs
Publication statusPublished - 5 Jun 2018

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Cardiovascular Diseases
Frail Elderly
Heart Failure
Peripheral Arterial Disease
Angina Pectoris
Proportional Hazards Models
Self Report
Medical Records
Longitudinal Studies
Comorbidity
Stroke
Myocardial Infarction
Quality of Life
Exercise

Keywords

  • Cardiovascular disease
  • Frailty
  • Heart failure
  • Older adults

Cite this

Kleipool, E. E. F., Hoogendijk, E. O., Trappenburg, M. C., Handoko, M. L., Huisman, M., Peters, M. J. L., & Muller, M. (2018). Frailty in older adults with cardiovascular disease: Cause, effect or both? Aging and Disease, 9(3), 489-497. https://doi.org/10.14336/AD.2017.1125
Kleipool, Emma E.F. ; Hoogendijk, Emiel O. ; Trappenburg, Marijke C. ; Handoko, M. Louis ; Huisman, Martijn ; Peters, Mike J.L. ; Muller, Majon. / Frailty in older adults with cardiovascular disease : Cause, effect or both?. In: Aging and Disease. 2018 ; Vol. 9, No. 3. pp. 489-497.
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Kleipool, EEF, Hoogendijk, EO, Trappenburg, MC, Handoko, ML, Huisman, M, Peters, MJL & Muller, M 2018, 'Frailty in older adults with cardiovascular disease: Cause, effect or both?' Aging and Disease, vol. 9, no. 3, pp. 489-497. https://doi.org/10.14336/AD.2017.1125

Frailty in older adults with cardiovascular disease : Cause, effect or both? / Kleipool, Emma E.F.; Hoogendijk, Emiel O.; Trappenburg, Marijke C.; Handoko, M. Louis; Huisman, Martijn; Peters, Mike J.L.; Muller, Majon.

In: Aging and Disease, Vol. 9, No. 3, 05.06.2018, p. 489-497.

Research output: Contribution to JournalArticleAcademicpeer-review

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Kleipool EEF, Hoogendijk EO, Trappenburg MC, Handoko ML, Huisman M, Peters MJL et al. Frailty in older adults with cardiovascular disease: Cause, effect or both? Aging and Disease. 2018 Jun 5;9(3):489-497. https://doi.org/10.14336/AD.2017.1125