Van gen tot medicijn: moderne ontwikkelingen in de farmacochemie

Translated title of the contribution: From gene to drug: recent developments in medicinal chemistry

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The development ofa new drug often takes more than ten years. Until recently, researchers were obliged to carry out experimental research on the efficacy of variants of those molecules of which the effect was known. It took a long time before a structure-activity relationship could be established. Currently, the full effect of the stormy developments in the Life Sciences, including the sequencing of the human genome, has not yet been fully felt in clinical practice. However, in laboratories researching medicinal products, the technology and the strategies being applied are changing drastically. Understanding disease processes and pharmaconprotein interactions at molecular level make it possible to develop biologically active pharmaceuticals using efficient developmental techniques involving crystallography and computer models. At the same time it is becoming clear that more research is necessary in order to understand the pharmacokinetic characteristics and toxicological activity of medicines under development. This second phase in the development of medicinal products too, is being strongly stimulated by the recent changes.

Translated title of the contributionFrom gene to drug: recent developments in medicinal chemistry
Original languageDutch
Pages (from-to)2795-800
Number of pages6
JournalNederlands Tijdschrift voor Geneeskunde
Volume152
Issue number51-52
Publication statusPublished - 20 Dec 2008

Keywords

  • Chemistry, Pharmaceutical
  • Drug Discovery
  • Genome, Human
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Netherlands
  • Pharmacology
  • Structure-Activity Relationship
  • Toxicology
  • English Abstract
  • Historical Article
  • Journal Article

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