TY - JOUR
T1 - From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function
AU - Smit, Martine J.
AU - van Muijlwijk-Koezen, Jacqueline E.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Chemokine receptors CXCR4 and atypical chemokine receptor 3 (ACKR3/CXCR7) are highly expressed in a range of tumors. Yet, their role in cancer progression is not well understood. This minireview series encompasses seven comprehensive reviews focusing on modulators (small molecules, pepducins, antibodies), structural aspects, spatio-temporal signaling properties, and phosphorylation/interactome of CXCR4 and ACKR3. Moreover, different (patho)physiologic aspects and roles of these receptors in immunologic and oncogenic processes are discussed. SIGNIFICANCE STATEMENT: CXCR4 and atypical chemokine receptor 3 are two oncogenic G protein-coupled receptors that are highly upregulated in various tumors. Insight into the signalling properties of these receptors and the availability of modulators targeting these receptors are essential to assess their role in cancer.
AB - Chemokine receptors CXCR4 and atypical chemokine receptor 3 (ACKR3/CXCR7) are highly expressed in a range of tumors. Yet, their role in cancer progression is not well understood. This minireview series encompasses seven comprehensive reviews focusing on modulators (small molecules, pepducins, antibodies), structural aspects, spatio-temporal signaling properties, and phosphorylation/interactome of CXCR4 and ACKR3. Moreover, different (patho)physiologic aspects and roles of these receptors in immunologic and oncogenic processes are discussed. SIGNIFICANCE STATEMENT: CXCR4 and atypical chemokine receptor 3 are two oncogenic G protein-coupled receptors that are highly upregulated in various tumors. Insight into the signalling properties of these receptors and the availability of modulators targeting these receptors are essential to assess their role in cancer.
UR - http://www.scopus.com/inward/record.url?scp=85075094296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075094296&partnerID=8YFLogxK
U2 - 10.1124/mol.119.118364
DO - 10.1124/mol.119.118364
M3 - Editorial
C2 - 31624136
AN - SCOPUS:85075094296
SN - 1521-0111
VL - 96
SP - 735
EP - 736
JO - Molecular pharmacology
JF - Molecular pharmacology
IS - 6
ER -
