Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability

D. Ruano; G.R. Abecasis; B. Glaser; E.S. Lips; L.N. Cornelisse; A.P.H. de Jong; D.M. Evans; D.G. Smith; N.J. Thimpson; A.B. Smit; P. Heutink; M. Verhage; D. Posthuma

doi:10.1016/j.ajhg.2009.12.006

Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability

D. Ruano, G.R. Abecasis, B. Glaser, E.S. Lips, L.N. Cornelisse, A.P.H. de Jong, D.M. Evans, D.G. Smith, N.J. Thimpson, A.B. Smit, P. Heutink, M. Verhage, D. Posthuma

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Abstract

Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of genes of small effect may be of importance for cognitive ability. We applied an innovative method in which we tested for the effect of groups of genes defined according to cellular function (functional gene group analysis). Using an initial sample of 627 subjects, this functional gene group analysis detected that synaptic heterotrimeric guanine nucleotide binding proteins (G proteins) play an important role in cognitive ability (P

Original language	English
Pages (from-to)	113-125
Journal	American Journal of Human Genetics
Volume	86
Issue number	2
DOIs	https://doi.org/10.1016/j.ajhg.2009.12.006
Publication status	Published - 2010

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Ruano, D., Abecasis, G. R., Glaser, B., Lips, E. S., Cornelisse, L. N., de Jong, A. P. H., Evans, D. M., Smith, D. G., Thimpson, N. J., Smit, A. B., Heutink, P., Verhage, M., & Posthuma, D. (2010). Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability. American Journal of Human Genetics, 86(2), 113-125. https://doi.org/10.1016/j.ajhg.2009.12.006

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abstract = "Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of genes of small effect may be of importance for cognitive ability. We applied an innovative method in which we tested for the effect of groups of genes defined according to cellular function (functional gene group analysis). Using an initial sample of 627 subjects, this functional gene group analysis detected that synaptic heterotrimeric guanine nucleotide binding proteins (G proteins) play an important role in cognitive ability (P",

author = "D. Ruano and G.R. Abecasis and B. Glaser and E.S. Lips and L.N. Cornelisse and {de Jong}, A.P.H. and D.M. Evans and D.G. Smith and N.J. Thimpson and A.B. Smit and P. Heutink and M. Verhage and D. Posthuma",

year = "2010",

doi = "10.1016/j.ajhg.2009.12.006",

language = "English",

volume = "86",

pages = "113--125",

journal = "American Journal of Human Genetics",

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Ruano, D, Abecasis, GR, Glaser, B, Lips, ES, Cornelisse, LN, de Jong, APH, Evans, DM, Smith, DG, Thimpson, NJ, Smit, AB, Heutink, P, Verhage, M & Posthuma, D 2010, 'Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability', American Journal of Human Genetics, vol. 86, no. 2, pp. 113-125. https://doi.org/10.1016/j.ajhg.2009.12.006

TY - JOUR

T1 - Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability

AU - Ruano, D.

AU - Abecasis, G.R.

AU - Glaser, B.

AU - Lips, E.S.

AU - Cornelisse, L.N.

AU - de Jong, A.P.H.

AU - Evans, D.M.

AU - Smith, D.G.

AU - Thimpson, N.J.

AU - Smit, A.B.

AU - Heutink, P.

AU - Verhage, M.

AU - Posthuma, D.

PY - 2010

Y1 - 2010

N2 - Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of genes of small effect may be of importance for cognitive ability. We applied an innovative method in which we tested for the effect of groups of genes defined according to cellular function (functional gene group analysis). Using an initial sample of 627 subjects, this functional gene group analysis detected that synaptic heterotrimeric guanine nucleotide binding proteins (G proteins) play an important role in cognitive ability (P

AB - Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of genes of small effect may be of importance for cognitive ability. We applied an innovative method in which we tested for the effect of groups of genes defined according to cellular function (functional gene group analysis). Using an initial sample of 627 subjects, this functional gene group analysis detected that synaptic heterotrimeric guanine nucleotide binding proteins (G proteins) play an important role in cognitive ability (P

U2 - 10.1016/j.ajhg.2009.12.006

DO - 10.1016/j.ajhg.2009.12.006

M3 - Article

SN - 0002-9297

VL - 86

SP - 113

EP - 125

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 2

ER -

Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability

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