Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse

R.M. Meredith, R. de Jong, H.D. Mansvelder

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Pharmaceutical treatments are being developed to correct specific behavioural and morphological aspects of neurodevelopmental disorders such as mental retardation. Fragile X syndrome is an X-linked mental retardation with abnormal dendritic protrusions from neurons in the brain. Increased signalling via excitatory metabotropic glutamate receptor (mGluR) pathways is hypothesised to contribute to this disorder. Targeting these receptors has shown improvements in both behaviour and morphology with the Fmr1-KO mouse model for the syndrome. It is not known whether similar changes occur in excitatory synaptic activity following treatment with mGluR antagonists. We tested the effects of prolonged mGluR blockade on excitatory synaptic activity at three developmental time points in hippocampal slices. We observed a rescue effect of the antagonist MPEP upon spontaneous EPSC amplitude and charge at 2. weeks but not 1. week or 8-10. weeks of development. These data support the role of mGluR antagonist treatment for functional synaptic correction at an early developmental stage in a model for fragile X syndrome. © 2010 Elsevier Inc.
Original languageEnglish
Pages (from-to)104-110
Number of pages6
JournalNeurobiology of Disease
Volume41
Issue number1
DOIs
Publication statusPublished - 2011

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