Functioning phosphorylation in liver mitochondria of high-fat diet fed rats.

J. Ciapaite, S.J.L. Bakker, G. van Eikenhorst, M.J. Wagner, C.G. Schalkwijk, T. Teerlink, M. Fodor, D.M. Ouwens, M. Diamant, R.J. Heine, H.V. Westerhoff, K. Krab

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24 ± 6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N
Original languageEnglish
Pages (from-to)307-316
JournalBiochimica et Biophysica Acta. Molecular Basis of Disease
Volume1772
DOIs
Publication statusPublished - 2007

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