Functioning phosphorylation in liver mitochondria of high-fat diet fed rats.

J. Ciapaite, S.J.L. Bakker, G. van Eikenhorst, M.J. Wagner, C.G. Schalkwijk, T. Teerlink, M. Fodor, D.M. Ouwens, M. Diamant, R.J. Heine, H.V. Westerhoff, K. Krab

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24 ± 6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N
    Original languageEnglish
    Pages (from-to)307-316
    JournalBiochimica et Biophysica Acta. Molecular Basis of Disease
    Volume1772
    DOIs
    Publication statusPublished - 2007

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