Functioning phosphorylation in liver mitochondria of high-fat diet fed rats.

J. Ciapaite; S.J.L. Bakker; G. van Eikenhorst; M.J. Wagner; C.G. Schalkwijk; T. Teerlink; M. Fodor; D.M. Ouwens; M. Diamant; R.J. Heine; H.V. Westerhoff; K. Krab

doi:10.1016/j.bbadis.2006.10.018

Functioning phosphorylation in liver mitochondria of high-fat diet fed rats.

J. Ciapaite, S.J.L. Bakker, G. van Eikenhorst, M.J. Wagner, C.G. Schalkwijk, T. Teerlink, M. Fodor, D.M. Ouwens, M. Diamant, R.J. Heine, H.V. Westerhoff, K. Krab

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24 ± 6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N

Original language	English
Pages (from-to)	307-316
Journal	Biochimica et Biophysica Acta. Molecular Basis of Disease
Volume	1772
DOIs	https://doi.org/10.1016/j.bbadis.2006.10.018
Publication status	Published - 2007

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Ciapaite, J., Bakker, S. J. L., van Eikenhorst, G., Wagner, M. J., Schalkwijk, C. G., Teerlink, T., Fodor, M., Ouwens, D. M., Diamant, M., Heine, R. J., Westerhoff, H. V., & Krab, K. (2007). Functioning phosphorylation in liver mitochondria of high-fat diet fed rats. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1772, 307-316. https://doi.org/10.1016/j.bbadis.2006.10.018

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title = "Functioning phosphorylation in liver mitochondria of high-fat diet fed rats.",

abstract = "We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24 ± 6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N",

author = "J. Ciapaite and S.J.L. Bakker and {van Eikenhorst}, G. and M.J. Wagner and C.G. Schalkwijk and T. Teerlink and M. Fodor and D.M. Ouwens and M. Diamant and R.J. Heine and H.V. Westerhoff and K. Krab",

year = "2007",

doi = "10.1016/j.bbadis.2006.10.018",

language = "English",

volume = "1772",

pages = "307--316",

journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",

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TY - JOUR

T1 - Functioning phosphorylation in liver mitochondria of high-fat diet fed rats.

AU - Ciapaite, J.

AU - Bakker, S.J.L.

AU - van Eikenhorst, G.

AU - Wagner, M.J.

AU - Schalkwijk, C.G.

AU - Teerlink, T.

AU - Fodor, M.

AU - Ouwens, D.M.

AU - Diamant, M.

AU - Heine, R.J.

AU - Westerhoff, H.V.

AU - Krab, K.

PY - 2007

Y1 - 2007

N2 - We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24 ± 6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N

AB - We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24 ± 6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N

U2 - 10.1016/j.bbadis.2006.10.018

DO - 10.1016/j.bbadis.2006.10.018

M3 - Article

VL - 1772

SP - 307

EP - 316

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

SN - 0925-4439

ER -

Functioning phosphorylation in liver mitochondria of high-fat diet fed rats.

Abstract

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