Abstract
We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24 ± 6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N
Original language | English |
---|---|
Pages (from-to) | 307-316 |
Journal | Biochimica et Biophysica Acta. Molecular Basis of Disease |
Volume | 1772 |
DOIs | |
Publication status | Published - 2007 |