Fungal mycobiome-mediated immune response: a non-negligible promoter in pancreatic oncogenesis and chemoresistance

Yaling Jiang, Valentina Donati, Godefridus J. Peters*, Elisa Giovannetti, Dong Mei Deng*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in humans due to late diagnosis and poor response to treatments. The tumor microenvironment (TME) of PDAC is characterized by a distinctive, suppressive immune profile, which inhibits the protective functions of anti-tumor immunity and thereby contributes to PDAC progression. Recently, the study of Alam et al. discovered for the first time that the intratumoral fungal mycobiome could contribute to the recruitment and activation of type 2 immune cells in the TME of PDAC via enhancing the secretion of a chemoattractant, interleukin (IL-) 33. In this article, we reviewed the important findings of this study. Together with our findings, we synthetically discussed the role of the fungal mycobiome in orchestrating the immune response and thereby modulating tumor progression.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalCancer Drug Resistance
Volume6
Issue number2
Early online date10 May 2023
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
This work was supported by grants from the Cancer Center Amsterdam (CCA) Foundation, As-sociazione Italiana per la Ricerca sul Cancro (AIRC) and Fondazione Pisana per la Scienza (FPS) to Giovannetti E, and the Dutch Research Council (NWO) (OCENW.XS22.4.135) to Jiang Y.

Publisher Copyright:
© The Author(s) 2023.

Funding

This work was supported by grants from the Cancer Center Amsterdam (CCA) Foundation, As-sociazione Italiana per la Ricerca sul Cancro (AIRC) and Fondazione Pisana per la Scienza (FPS) to Giovannetti E, and the Dutch Research Council (NWO) (OCENW.XS22.4.135) to Jiang Y.

FundersFunder number
As-sociazione Italiana per la Ricerca sul Cancro
Fondazione Pisana per la Scienza
Nederlandse Organisatie voor Wetenschappelijk OnderzoekOCENW.XS22.4.135
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Cancer Center Amsterdam

    Keywords

    • chemoresistance
    • interleukin 33
    • Mycobiome
    • pancreatic cancer
    • type 2 immune cells

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