Further confirmation of the association between anxiety and CTNND2: replication in humans

M.G. Nivard; H. Mbarek; J.J. Hottenga; J.H. Smit; B.W.J.H. Penninx; C.M. Middeldorp; D.I. Boomsma

doi:10.1111/gbb.12095

Further confirmation of the association between anxiety and CTNND2: replication in humans

M.G. Nivard, H. Mbarek, J.J. Hottenga, J.H. Smit, B.W.J.H. Penninx, C.M. Middeldorp, D.I. Boomsma

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The rat genome sequencing and mapping consortium found evidence for an association between the catenin-δ2 gene (CTNND2) and anxious behaviour. We replicated these results in humans by carrying out a genetic association test in patients with panic disorder, social phobia, generalized anxiety disorder and/or agoraphobia (N=1714) and controls (N=4125). We further explored the association between CTNND2 and other psychiatric disorders based on publicly available genome-wide association results. A gene-based test showed that single nucleotide polymorphisms (SNPs) in CTNND2 have a significantly increased signal (P<1e

Original language	English
Pages (from-to)	195-201
Number of pages	7
Journal	Genes, Brain and Behavior
Volume	13
Issue number	2
DOIs	https://doi.org/10.1111/gbb.12095
Publication status	Published - 2014

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10.1111/gbb.12095

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abstract = "The rat genome sequencing and mapping consortium found evidence for an association between the catenin-δ2 gene (CTNND2) and anxious behaviour. We replicated these results in humans by carrying out a genetic association test in patients with panic disorder, social phobia, generalized anxiety disorder and/or agoraphobia (N=1714) and controls (N=4125). We further explored the association between CTNND2 and other psychiatric disorders based on publicly available genome-wide association results. A gene-based test showed that single nucleotide polymorphisms (SNPs) in CTNND2 have a significantly increased signal (P<1e",

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AU - Nivard, M.G.

AU - Mbarek, H.

AU - Hottenga, J.J.

AU - Smit, J.H.

AU - Penninx, B.W.J.H.

AU - Middeldorp, C.M.

AU - Boomsma, D.I.

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JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

IS - 2

ER -

Further confirmation of the association between anxiety and CTNND2: replication in humans

Abstract

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UN SDGs

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