Further confirmation of the association between anxiety and CTNND2: replication in humans

M.G. Nivard, H. Mbarek, J.J. Hottenga, J.H. Smit, B.W.J.H. Penninx, C.M. Middeldorp, D.I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The rat genome sequencing and mapping consortium found evidence for an association between the catenin-δ2 gene (CTNND2) and anxious behaviour. We replicated these results in humans by carrying out a genetic association test in patients with panic disorder, social phobia, generalized anxiety disorder and/or agoraphobia (N=1714) and controls (N=4125). We further explored the association between CTNND2 and other psychiatric disorders based on publicly available genome-wide association results. A gene-based test showed that single nucleotide polymorphisms (SNPs) in CTNND2 have a significantly increased signal (P<1e
Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalGenes, Brain and Behavior
Volume13
Issue number2
DOIs
Publication statusPublished - 2014

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