Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

H. Zhao; E. Eising; B. de Vries; L.S. Vijfhuizen; V. Anttila; B.S. Winsvold; T. Kurth; H. Stefansson; M. Kallela; R. Malik; A.H. Stam; M. Arfan Ikram; L. Ligthart; T. Freilinger; M. Alexander; B. Müller-Myhsok; S Schreiber; T. Meitinger; A. Aromas; J.G. Eriksson; D.I. Boomsma; C.M. van Duijn; J.A. Zwart; L. Quaye; C. Kubisch; M. Dichgans; M. Wessman; K. Stefansson; D.I. Chasman; A. Palotie; N.G. Martin; G.W. Montgomery; M.D. Ferrari; G.M. Terwindt; A.M.J.M. van den Maagdenberg; DR Nyholt

doi:10.1177/0333102415591497

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

H. Zhao, E. Eising, B. de Vries, L.S. Vijfhuizen, V. Anttila, B.S. Winsvold, T. Kurth, H. Stefansson, M. Kallela, R. Malik, A.H. Stam, M. Arfan Ikram, L. Ligthart, T. Freilinger, M. Alexander, B. Müller-Myhsok, S Schreiber, T. Meitinger, A. Aromas, J.G. ErikssonD.I. Boomsma, C.M. van Duijn, J.A. Zwart, L. Quaye, C. Kubisch, M. Dichgans, M. Wessman, K. Stefansson, D.I. Chasman, A. Palotie, N.G. Martin, G.W. Montgomery, M.D. Ferrari, G.M. Terwindt, A.M.J.M. van den Maagdenberg, DR Nyholt

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Introduction It is unclear whether patients diagnosed according to International Classification of Headache Disorders criteria for migraine with aura (MA) and migraine without aura (MO) experience distinct disorders or whether their migraine subtypes are genetically related. Aim Using a novel gene-based (statistical) approach, we aimed to identify individual genes and pathways associated both with MA and MO. Methods Gene-based tests were performed using genome-wide association summary statistic results from the most recent International Headache Genetics Consortium study comparing 4505 MA cases with 34,813 controls and 4038 MO cases with 40,294 controls. After accounting for non-independence of gene-based test results, we examined the significance of the proportion of shared genes associated with MA and MO. Results We found a significant overlap in genes associated with MA and MO. Of the total 1514 genes with a nominally significant gene-based p value (p

Original language	English
Pages (from-to)	648-657
Journal	Cephalalgia
Volume	36
Issue number	7
DOIs	https://doi.org/10.1177/0333102415591497
Publication status	Published - 2016

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Zhao, H., Eising, E., de Vries, B., Vijfhuizen, L. S., Anttila, V., Winsvold, B. S., Kurth, T., Stefansson, H., Kallela, M., Malik, R., Stam, A. H., Arfan Ikram, M., Ligthart, L., Freilinger, T., Alexander, M., Müller-Myhsok, B., Schreiber, S., Meitinger, T., Aromas, A., ... Nyholt, DR. (2016). Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. Cephalalgia, 36(7), 648-657. https://doi.org/10.1177/0333102415591497

@article{410473bf4d3f47d3ad44bdf630b8ef20,

title = "Gene-based pleiotropy across migraine with aura and migraine without aura patient groups",

abstract = "Introduction It is unclear whether patients diagnosed according to International Classification of Headache Disorders criteria for migraine with aura (MA) and migraine without aura (MO) experience distinct disorders or whether their migraine subtypes are genetically related. Aim Using a novel gene-based (statistical) approach, we aimed to identify individual genes and pathways associated both with MA and MO. Methods Gene-based tests were performed using genome-wide association summary statistic results from the most recent International Headache Genetics Consortium study comparing 4505 MA cases with 34,813 controls and 4038 MO cases with 40,294 controls. After accounting for non-independence of gene-based test results, we examined the significance of the proportion of shared genes associated with MA and MO. Results We found a significant overlap in genes associated with MA and MO. Of the total 1514 genes with a nominally significant gene-based p value (p",

author = "H. Zhao and E. Eising and {de Vries}, B. and L.S. Vijfhuizen and V. Anttila and B.S. Winsvold and T. Kurth and H. Stefansson and M. Kallela and R. Malik and A.H. Stam and {Arfan Ikram}, M. and L. Ligthart and T. Freilinger and M. Alexander and B. M{\"u}ller-Myhsok and S Schreiber and T. Meitinger and A. Aromas and J.G. Eriksson and D.I. Boomsma and {van Duijn}, C.M. and J.A. Zwart and L. Quaye and C. Kubisch and M. Dichgans and M. Wessman and K. Stefansson and D.I. Chasman and A. Palotie and N.G. Martin and G.W. Montgomery and M.D. Ferrari and G.M. Terwindt and {van den Maagdenberg}, A.M.J.M. and DR Nyholt",

year = "2016",

doi = "10.1177/0333102415591497",

language = "English",

volume = "36",

pages = "648--657",

journal = "Cephalalgia",

issn = "0333-1024",

publisher = "SAGE Publications Ltd",

number = "7",

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Zhao, H, Eising, E, de Vries, B, Vijfhuizen, LS, Anttila, V, Winsvold, BS, Kurth, T, Stefansson, H, Kallela, M, Malik, R, Stam, AH, Arfan Ikram, M, Ligthart, L, Freilinger, T, Alexander, M, Müller-Myhsok, B, Schreiber, S, Meitinger, T, Aromas, A, Eriksson, JG, Boomsma, DI, van Duijn, CM, Zwart, JA, Quaye, L, Kubisch, C, Dichgans, M, Wessman, M, Stefansson, K, Chasman, DI, Palotie, A, Martin, NG, Montgomery, GW, Ferrari, MD, Terwindt, GM, van den Maagdenberg, AMJM & Nyholt, DR 2016, 'Gene-based pleiotropy across migraine with aura and migraine without aura patient groups', Cephalalgia, vol. 36, no. 7, pp. 648-657. https://doi.org/10.1177/0333102415591497

TY - JOUR

T1 - Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

AU - Zhao, H.

AU - Eising, E.

AU - de Vries, B.

AU - Vijfhuizen, L.S.

AU - Anttila, V.

AU - Winsvold, B.S.

AU - Kurth, T.

AU - Stefansson, H.

AU - Kallela, M.

AU - Malik, R.

AU - Stam, A.H.

AU - Arfan Ikram, M.

AU - Ligthart, L.

AU - Freilinger, T.

AU - Alexander, M.

AU - Müller-Myhsok, B.

AU - Schreiber, S

AU - Meitinger, T.

AU - Aromas, A.

AU - Eriksson, J.G.

AU - Boomsma, D.I.

AU - van Duijn, C.M.

AU - Zwart, J.A.

AU - Quaye, L.

AU - Kubisch, C.

AU - Dichgans, M.

AU - Wessman, M.

AU - Stefansson, K.

AU - Chasman, D.I.

AU - Palotie, A.

AU - Martin, N.G.

AU - Montgomery, G.W.

AU - Ferrari, M.D.

AU - Terwindt, G.M.

AU - van den Maagdenberg, A.M.J.M.

AU - Nyholt, DR

PY - 2016

Y1 - 2016

N2 - Introduction It is unclear whether patients diagnosed according to International Classification of Headache Disorders criteria for migraine with aura (MA) and migraine without aura (MO) experience distinct disorders or whether their migraine subtypes are genetically related. Aim Using a novel gene-based (statistical) approach, we aimed to identify individual genes and pathways associated both with MA and MO. Methods Gene-based tests were performed using genome-wide association summary statistic results from the most recent International Headache Genetics Consortium study comparing 4505 MA cases with 34,813 controls and 4038 MO cases with 40,294 controls. After accounting for non-independence of gene-based test results, we examined the significance of the proportion of shared genes associated with MA and MO. Results We found a significant overlap in genes associated with MA and MO. Of the total 1514 genes with a nominally significant gene-based p value (p

AB - Introduction It is unclear whether patients diagnosed according to International Classification of Headache Disorders criteria for migraine with aura (MA) and migraine without aura (MO) experience distinct disorders or whether their migraine subtypes are genetically related. Aim Using a novel gene-based (statistical) approach, we aimed to identify individual genes and pathways associated both with MA and MO. Methods Gene-based tests were performed using genome-wide association summary statistic results from the most recent International Headache Genetics Consortium study comparing 4505 MA cases with 34,813 controls and 4038 MO cases with 40,294 controls. After accounting for non-independence of gene-based test results, we examined the significance of the proportion of shared genes associated with MA and MO. Results We found a significant overlap in genes associated with MA and MO. Of the total 1514 genes with a nominally significant gene-based p value (p

U2 - 10.1177/0333102415591497

DO - 10.1177/0333102415591497

M3 - Article

SN - 0333-1024

VL - 36

SP - 648

EP - 657

JO - Cephalalgia

JF - Cephalalgia

IS - 7

ER -

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

Abstract

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UN SDGs

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