TY - JOUR
T1 - Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
AU - Lee, James J
AU - Wedow, Robbee
AU - Okbay, Aysu
AU - Kong, Edward
AU - Maghzian, Omeed
AU - Zacher, Meghan
AU - 23Andme Research Team
AU - Nguyen-Viet, Tuan Anh
AU - Bowers, Peter
AU - Sidorenko, Julia
AU - Karlsson Linnér, Richard
AU - Fontana, Mark Alan
AU - Kundu, Tushar
AU - Lee, Chanwook
AU - Li, Hui
AU - Li, Ruoxi
AU - Royer, Rebecca
AU - Timshel, Pascal N
AU - Walters, Raymond K
AU - Willoughby, Emily A
AU - Yengo, Loïc
AU - Alver, Maris
AU - Bao, Yanchun
AU - Clark, David W
AU - Day, Felix R
AU - Furlotte, Nicholas A
AU - Joshi, Peter K
AU - Kemper, Kathryn E
AU - Kleinman, Aaron
AU - Langenberg, Claudia
AU - Mägi, Reedik
AU - Trampush, Joey W
AU - Verma, Shefali Setia
AU - Wu, Yang
AU - Lam, Max
AU - Zhao, Jing Hua
AU - Zheng, Zhili
AU - Boardman, Jason D
AU - Campbell, Harry
AU - Freese, Jeremy
AU - Harris, Kathleen Mullan
AU - Hayward, Caroline
AU - Herd, Pamela
AU - Kumari, Meena
AU - Lencz, Todd
AU - Luan, Jian'an
AU - Malhotra, Anil K
AU - Metspalu, Andres
AU - Milani, Lili
AU - Lehrer, Steven F
AU - Koellinger, Philipp D
AU - Abdellaoui, A.
AU - Peyrot, Wouter J
AU - Hottenga, J.J.
AU - Vinkhuyzen, A.A.E.
AU - Willemsen, Gonneke
AU - Boomsma, D.I.
AU - van Duijn, Cornelia M
AU - Penninx, Brenda
AU - Posthuma, Danielle
AU - Uitterlinden, André G
PY - 2018/8
Y1 - 2018/8
N2 - Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
AB - Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
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U2 - 10.1038/s41588-018-0147-3
DO - 10.1038/s41588-018-0147-3
M3 - Article
C2 - 30038396
SN - 1061-4036
VL - 50
SP - 1112
EP - 1121
JO - Nature Genetics
JF - Nature Genetics
IS - 8
ER -
