Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

K. Silventoinen; A. Jelenkovic; R. Sund; Y.M. Hur; Y. Yokoyama; C. Honda; J. Hjelmborg; S. Möller; S. Ooki; S. Aaltonen; F. Ji; F. Ning; Z. Pang; E. Rebato; A. Busjahn; C. Kandler; K.J. Saudino; K.L. Jang; W. Cozen; A.E. Hwang; T.M. Mack; W. Gao; C. Yu; L. Li; R.P. Corley; B.M. Huibregtse; K. Christensen; A. Skytthe; K.O. Kyvik; C.A. Derom; R.F. Vlietinck; R.J.F. Loos; K. Heikkilä; J. Wardle; C.H. Llewellyn; A. Fisher; T.A. McAdams; T.C. Eley; A.M. Gregory; M. He; X. Ding; M. Bjerregaard-Andersen; H. Beck-Nielsen; M. Sodemann; A.D. Tarnoki; D.L. Tarnoki; M.A. Stazi; C. Fagnani; C. D'Ippolito; A. Knafo-Noam; D. Mankuta; L. Abramson; S.A. Burt; K.L. Klump; J.L. Silberg; L.J. Eaves; H.H. Maes; R.F. Krueger; M. McGue; S. Pahlen; M. Gatz; D.A. Butler; M. Bartels; C.E.M. van Beijsterveldt; J.M. Craig; R. Saffery; D.L. Freitas; J.A. Maia; L. Dubois; M. Boivin; M. Brendgen; G. Dionne; F. Vitaro; N.G. Martin; S.E. Medland; G.W. Montgomery; Y. Chong; G.E. Swan; R. Krasnow; P.K.E. Magnusson; N.L. Pedersen; P. Tynelius; P. Lichtenstein; C.M.A. Haworth; R. Plomin; G. Bayasgalan; D. Narandalai; K.P. Harden; E.M. Tucker-Drob; S.Y. Öncel; F. Aliev; T.D. Spector; M. Mangino; G. Lachance; L.A. Baker; C. Tuvblad; G.E. Duncan; D. Buchwald; G. Willemsen; F. Rasmussen; J.H. Goldberg; T.I.A. Sørensen; D.I. Boomsma; J. Kaprio

doi:10.3945/ajcn.116.130252

Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

K. Silventoinen, A. Jelenkovic, R. Sund, Y.M. Hur, Y. Yokoyama, C. Honda, J. Hjelmborg, S. Möller, S. Ooki, S. Aaltonen, F. Ji, F. Ning, Z. Pang, E. Rebato, A. Busjahn, C. Kandler, K.J. Saudino, K.L. Jang, W. Cozen, A.E. HwangT.M. Mack, W. Gao, C. Yu, L. Li, R.P. Corley, B.M. Huibregtse, K. Christensen, A. Skytthe, K.O. Kyvik, C.A. Derom, R.F. Vlietinck, R.J.F. Loos, K. Heikkilä, J. Wardle, C.H. Llewellyn, A. Fisher, T.A. McAdams, T.C. Eley, A.M. Gregory, M. He, X. Ding, M. Bjerregaard-Andersen, H. Beck-Nielsen, M. Sodemann, A.D. Tarnoki, D.L. Tarnoki, M.A. Stazi, C. Fagnani, C. D'Ippolito, A. Knafo-Noam, D. Mankuta, L. Abramson, S.A. Burt, K.L. Klump, J.L. Silberg, L.J. Eaves, H.H. Maes, R.F. Krueger, M. McGue, S. Pahlen, M. Gatz, D.A. Butler, M. Bartels, C.E.M. van Beijsterveldt, J.M. Craig, R. Saffery, D.L. Freitas, J.A. Maia, L. Dubois, M. Boivin, M. Brendgen, G. Dionne, F. Vitaro, N.G. Martin, S.E. Medland, G.W. Montgomery, Y. Chong, G.E. Swan, R. Krasnow, P.K.E. Magnusson, N.L. Pedersen, P. Tynelius, P. Lichtenstein, C.M.A. Haworth, R. Plomin, G. Bayasgalan, D. Narandalai, K.P. Harden, E.M. Tucker-Drob, S.Y. Öncel, F. Aliev, T.D. Spector, M. Mangino, G. Lachance, L.A. Baker, C. Tuvblad, G.E. Duncan, D. Buchwald, G. Willemsen, F. Rasmussen, J.H. Goldberg, T.I.A. Sørensen, D.I. Boomsma, J. Kaprio

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

Original language	English
Pages (from-to)	371-379
Journal	The American Journal of Clinical Nutrition
Volume	104
Issue number	2
DOIs	https://doi.org/10.3945/ajcn.116.130252
Publication status	Published - 2016

Cohort Studies

Netherlands Twin Register (NTR)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Silventoinen, K., Jelenkovic, A., Sund, R., Hur, Y. M., Yokoyama, Y., Honda, C., Hjelmborg, J., Möller, S., Ooki, S., Aaltonen, S., Ji, F., Ning, F., Pang, Z., Rebato, E., Busjahn, A., Kandler, C., Saudino, K. J., Jang, K. L., Cozen, W., ... Kaprio, J. (2016). Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. The American Journal of Clinical Nutrition, 104(2), 371-379. https://doi.org/10.3945/ajcn.116.130252

Silventoinen, K. ; Jelenkovic, A. ; Sund, R. et al. / Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. In: The American Journal of Clinical Nutrition. 2016 ; Vol. 104, No. 2. pp. 371-379.

@article{c8d2f4e0dda94333bdcf9b1e61103784,

title = "Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study",

abstract = "Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.",

author = "K. Silventoinen and A. Jelenkovic and R. Sund and Y.M. Hur and Y. Yokoyama and C. Honda and J. Hjelmborg and S. M{\"o}ller and S. Ooki and S. Aaltonen and F. Ji and F. Ning and Z. Pang and E. Rebato and A. Busjahn and C. Kandler and K.J. Saudino and K.L. Jang and W. Cozen and A.E. Hwang and T.M. Mack and W. Gao and C. Yu and L. Li and R.P. Corley and B.M. Huibregtse and K. Christensen and A. Skytthe and K.O. Kyvik and C.A. Derom and R.F. Vlietinck and R.J.F. Loos and K. Heikkil{\"a} and J. Wardle and C.H. Llewellyn and A. Fisher and T.A. McAdams and T.C. Eley and A.M. Gregory and M. He and X. Ding and M. Bjerregaard-Andersen and H. Beck-Nielsen and M. Sodemann and A.D. Tarnoki and D.L. Tarnoki and M.A. Stazi and C. Fagnani and C. D'Ippolito and A. Knafo-Noam and D. Mankuta and L. Abramson and S.A. Burt and K.L. Klump and J.L. Silberg and L.J. Eaves and H.H. Maes and R.F. Krueger and M. McGue and S. Pahlen and M. Gatz and D.A. Butler and M. Bartels and {van Beijsterveldt}, C.E.M. and J.M. Craig and R. Saffery and D.L. Freitas and J.A. Maia and L. Dubois and M. Boivin and M. Brendgen and G. Dionne and F. Vitaro and N.G. Martin and S.E. Medland and G.W. Montgomery and Y. Chong and G.E. Swan and R. Krasnow and P.K.E. Magnusson and N.L. Pedersen and P. Tynelius and P. Lichtenstein and C.M.A. Haworth and R. Plomin and G. Bayasgalan and D. Narandalai and K.P. Harden and E.M. Tucker-Drob and S.Y. {\"O}ncel and F. Aliev and T.D. Spector and M. Mangino and G. Lachance and L.A. Baker and C. Tuvblad and G.E. Duncan and D. Buchwald and G. Willemsen and F. Rasmussen and J.H. Goldberg and T.I.A. S{\o}rensen and D.I. Boomsma and J. Kaprio",

year = "2016",

doi = "10.3945/ajcn.116.130252",

language = "English",

volume = "104",

pages = "371--379",

journal = "The American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier B.V.",

number = "2",

}

Silventoinen, K, Jelenkovic, A, Sund, R, Hur, YM, Yokoyama, Y, Honda, C, Hjelmborg, J, Möller, S, Ooki, S, Aaltonen, S, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Christensen, K, Skytthe, A, Kyvik, KO, Derom, CA, Vlietinck, RF, Loos, RJF, Heikkilä, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Stazi, MA, Fagnani, C, D'Ippolito, C, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, CEM, Craig, JM, Saffery, R, Freitas, DL, Maia, JA, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Chong, Y, Swan, GE, Krasnow, R, Magnusson, PKE, Pedersen, NL, Tynelius, P, Lichtenstein, P, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Öncel, SY, Aliev, F, Spector, TD, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Rasmussen, F, Goldberg, JH, Sørensen, TIA, Boomsma, DI & Kaprio, J 2016, 'Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study', The American Journal of Clinical Nutrition, vol. 104, no. 2, pp. 371-379. https://doi.org/10.3945/ajcn.116.130252

Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. / Silventoinen, K.; Jelenkovic, A.; Sund, R. et al.
In: The American Journal of Clinical Nutrition, Vol. 104, No. 2, 2016, p. 371-379.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

AU - Silventoinen, K.

AU - Jelenkovic, A.

AU - Sund, R.

AU - Hur, Y.M.

AU - Yokoyama, Y.

AU - Honda, C.

AU - Hjelmborg, J.

AU - Möller, S.

AU - Ooki, S.

AU - Aaltonen, S.

AU - Ji, F.

AU - Ning, F.

AU - Pang, Z.

AU - Rebato, E.

AU - Busjahn, A.

AU - Kandler, C.

AU - Saudino, K.J.

AU - Jang, K.L.

AU - Cozen, W.

AU - Hwang, A.E.

AU - Mack, T.M.

AU - Gao, W.

AU - Yu, C.

AU - Li, L.

AU - Corley, R.P.

AU - Huibregtse, B.M.

AU - Christensen, K.

AU - Skytthe, A.

AU - Kyvik, K.O.

AU - Derom, C.A.

AU - Vlietinck, R.F.

AU - Loos, R.J.F.

AU - Heikkilä, K.

AU - Wardle, J.

AU - Llewellyn, C.H.

AU - Fisher, A.

AU - McAdams, T.A.

AU - Eley, T.C.

AU - Gregory, A.M.

AU - He, M.

AU - Ding, X.

AU - Bjerregaard-Andersen, M.

AU - Beck-Nielsen, H.

AU - Sodemann, M.

AU - Tarnoki, A.D.

AU - Tarnoki, D.L.

AU - Stazi, M.A.

AU - Fagnani, C.

AU - D'Ippolito, C.

AU - Knafo-Noam, A.

AU - Mankuta, D.

AU - Abramson, L.

AU - Burt, S.A.

AU - Klump, K.L.

AU - Silberg, J.L.

AU - Eaves, L.J.

AU - Maes, H.H.

AU - Krueger, R.F.

AU - McGue, M.

AU - Pahlen, S.

AU - Gatz, M.

AU - Butler, D.A.

AU - Bartels, M.

AU - van Beijsterveldt, C.E.M.

AU - Craig, J.M.

AU - Saffery, R.

AU - Freitas, D.L.

AU - Maia, J.A.

AU - Dubois, L.

AU - Boivin, M.

AU - Brendgen, M.

AU - Dionne, G.

AU - Vitaro, F.

AU - Martin, N.G.

AU - Medland, S.E.

AU - Montgomery, G.W.

AU - Chong, Y.

AU - Swan, G.E.

AU - Krasnow, R.

AU - Magnusson, P.K.E.

AU - Pedersen, N.L.

AU - Tynelius, P.

AU - Lichtenstein, P.

AU - Haworth, C.M.A.

AU - Plomin, R.

AU - Bayasgalan, G.

AU - Narandalai, D.

AU - Harden, K.P.

AU - Tucker-Drob, E.M.

AU - Öncel, S.Y.

AU - Aliev, F.

AU - Spector, T.D.

AU - Mangino, M.

AU - Lachance, G.

AU - Baker, L.A.

AU - Tuvblad, C.

AU - Duncan, G.E.

AU - Buchwald, D.

AU - Willemsen, G.

AU - Rasmussen, F.

AU - Goldberg, J.H.

AU - Sørensen, T.I.A.

AU - Boomsma, D.I.

AU - Kaprio, J.

PY - 2016

Y1 - 2016

N2 - Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

AB - Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

U2 - 10.3945/ajcn.116.130252

DO - 10.3945/ajcn.116.130252

M3 - Article

SN - 0002-9165

VL - 104

SP - 371

EP - 379

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

IS - 2

ER -

Silventoinen K, Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Honda C et al. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. The American Journal of Clinical Nutrition. 2016;104(2):371-379. doi: 10.3945/ajcn.116.130252