Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

A. Jelenkovic; R. Sund; Y.M. Hur; Y. Yokoyama; J. Hjelmborg; S. Möller; C. Honda; P.K.E. Magnusson; N.L. Pedersen; S. Ooki; S. Aaltonen; M.A. Stazi; C. Fagnani; C. D'Ippolito; D.L. Freitas; D. Antonio Maia; F. Ji; F. Ning; Z. Pang; E. Rebato; A. Busjahn; C. Kandler; K.J. Saudino; K.L. Jang; W. Cozen; A.E. Hwang; T.M. Mack; W. Gao; C. Yu; L. Li; R.P. Corley; B.M. Huibregtse; C.A. Derom; R.F. Vlietinck; R.J.F. Loos; K. Heikkilä; J. Wardle; C.H. Llewellyn; A. Fisher; T.A. McAdams; T.C. Eley; A.M. Gregory; M. He; X. Ding; M. Bjerregaard-Andersen; H. Beck-Nielsen; M. Sodemann; A.D. Tarnoki; D.L. Tarnoki; A. Knafo-Noam; D. Mankuta; L. Abramson; S.A. Burt; K.L. Klump; J.L. Silberg; L.J. Eaves; H.H. Maes; R.F. Krueger; M. McGue; S. Pahlen; M. Gatz; D.A. Butler; M. Bartels; C.E.M. van Beijsterveldt; J.M. Craig; R. Saffery; L. Dubois; M. Boivin; M. Brendgen; G. Dionne; F. Vitaro; N.G. Martin; S.E. Medland; G.W. Montgomery; G.E. Swan; R. Krasnow; P. Tynelius; P. Lichtenstein; C.M.A. Haworth; R. Plomin; G. Bayasgalan; D. Narandalai; K.P. Harden; E.M. Tucker-Drob; T.D. Spector; M. Mangino; G. Lachance; L.A. Baker; C. Tuvblad; G.E. Duncan; D. Buchwald; G. Willemsen; A. Skytthe; K.O. Kyvik; K. Christensen; S.Y. Öncel; F. Aliev; F. Rasmussen; J.H. Goldberg; T.I.A. Sørensen; D.I. Boomsma; J. Kaprio; K. Silventoinen

doi:10.1038/srep28496

Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

A. Jelenkovic, R. Sund, Y.M. Hur, Y. Yokoyama, J. Hjelmborg, S. Möller, C. Honda, P.K.E. Magnusson, N.L. Pedersen, S. Ooki, S. Aaltonen, M.A. Stazi, C. Fagnani, C. D'Ippolito, D.L. Freitas, D. Antonio Maia, F. Ji, F. Ning, Z. Pang, E. RebatoA. Busjahn, C. Kandler, K.J. Saudino, K.L. Jang, W. Cozen, A.E. Hwang, T.M. Mack, W. Gao, C. Yu, L. Li, R.P. Corley, B.M. Huibregtse, C.A. Derom, R.F. Vlietinck, R.J.F. Loos, K. Heikkilä, J. Wardle, C.H. Llewellyn, A. Fisher, T.A. McAdams, T.C. Eley, A.M. Gregory, M. He, X. Ding, M. Bjerregaard-Andersen, H. Beck-Nielsen, M. Sodemann, A.D. Tarnoki, D.L. Tarnoki, A. Knafo-Noam, D. Mankuta, L. Abramson, S.A. Burt, K.L. Klump, J.L. Silberg, L.J. Eaves, H.H. Maes, R.F. Krueger, M. McGue, S. Pahlen, M. Gatz, D.A. Butler, M. Bartels, C.E.M. van Beijsterveldt, J.M. Craig, R. Saffery, L. Dubois, M. Boivin, M. Brendgen, G. Dionne, F. Vitaro, N.G. Martin, S.E. Medland, G.W. Montgomery, G.E. Swan, R. Krasnow, P. Tynelius, P. Lichtenstein, C.M.A. Haworth, R. Plomin, G. Bayasgalan, D. Narandalai, K.P. Harden, E.M. Tucker-Drob, T.D. Spector, M. Mangino, G. Lachance, L.A. Baker, C. Tuvblad, G.E. Duncan, D. Buchwald, G. Willemsen, A. Skytthe, K.O. Kyvik, K. Christensen, S.Y. Öncel, F. Aliev, F. Rasmussen, J.H. Goldberg, T.I.A. Sørensen, D.I. Boomsma, J. Kaprio, K. Silventoinen

Biological Psychology

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Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Original language	English
Article number	28496
Pages (from-to)	1-13
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep28496
Publication status	Published - 2016

Cohort Studies

Netherlands Twin Register (NTR)

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Jelenkovic, A., Sund, R., Hur, Y. M., Yokoyama, Y., Hjelmborg, J., Möller, S., Honda, C., Magnusson, P. K. E., Pedersen, N. L., Ooki, S., Aaltonen, S., Stazi, M. A., Fagnani, C., D'Ippolito, C., Freitas, D. L., Antonio Maia, D., Ji, F., Ning, F., Pang, Z., ... Silventoinen, K. (2016). Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. Scientific Reports, 6, 1-13. [28496]. https://doi.org/10.1038/srep28496

@article{0187360dc4be4d4393fc99a4bd561e4e,

title = "Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts",

abstract = "Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.",

author = "A. Jelenkovic and R. Sund and Y.M. Hur and Y. Yokoyama and J. Hjelmborg and S. M{\"o}ller and C. Honda and P.K.E. Magnusson and N.L. Pedersen and S. Ooki and S. Aaltonen and M.A. Stazi and C. Fagnani and C. D'Ippolito and D.L. Freitas and {Antonio Maia}, D. and F. Ji and F. Ning and Z. Pang and E. Rebato and A. Busjahn and C. Kandler and K.J. Saudino and K.L. Jang and W. Cozen and A.E. Hwang and T.M. Mack and W. Gao and C. Yu and L. Li and R.P. Corley and B.M. Huibregtse and C.A. Derom and R.F. Vlietinck and R.J.F. Loos and K. Heikkil{\"a} and J. Wardle and C.H. Llewellyn and A. Fisher and T.A. McAdams and T.C. Eley and A.M. Gregory and M. He and X. Ding and M. Bjerregaard-Andersen and H. Beck-Nielsen and M. Sodemann and A.D. Tarnoki and D.L. Tarnoki and A. Knafo-Noam and D. Mankuta and L. Abramson and S.A. Burt and K.L. Klump and J.L. Silberg and L.J. Eaves and H.H. Maes and R.F. Krueger and M. McGue and S. Pahlen and M. Gatz and D.A. Butler and M. Bartels and {van Beijsterveldt}, C.E.M. and J.M. Craig and R. Saffery and L. Dubois and M. Boivin and M. Brendgen and G. Dionne and F. Vitaro and N.G. Martin and S.E. Medland and G.W. Montgomery and G.E. Swan and R. Krasnow and P. Tynelius and P. Lichtenstein and C.M.A. Haworth and R. Plomin and G. Bayasgalan and D. Narandalai and K.P. Harden and E.M. Tucker-Drob and T.D. Spector and M. Mangino and G. Lachance and L.A. Baker and C. Tuvblad and G.E. Duncan and D. Buchwald and G. Willemsen and A. Skytthe and K.O. Kyvik and K. Christensen and S.Y. {\"O}ncel and F. Aliev and F. Rasmussen and J.H. Goldberg and T.I.A. S{\o}rensen and D.I. Boomsma and J. Kaprio and K. Silventoinen",

year = "2016",

doi = "10.1038/srep28496",

language = "English",

volume = "6",

pages = "1--13",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

Jelenkovic, A, Sund, R, Hur, YM, Yokoyama, Y, Hjelmborg, J, Möller, S, Honda, C, Magnusson, PKE, Pedersen, NL, Ooki, S, Aaltonen, S, Stazi, MA, Fagnani, C, D'Ippolito, C, Freitas, DL, Antonio Maia, D, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Heikkilä, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M , van Beijsterveldt, CEM, Craig, JM, Saffery, R, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Swan, GE, Krasnow, R, Tynelius, P, Lichtenstein, P, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Spector, TD, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Skytthe, A, Kyvik, KO, Christensen, K, Öncel, SY, Aliev, F, Rasmussen, F, Goldberg, JH, Sørensen, TIA, Boomsma, DI, Kaprio, J & Silventoinen, K 2016, 'Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts', Scientific Reports, vol. 6, 28496, pp. 1-13. https://doi.org/10.1038/srep28496

TY - JOUR

T1 - Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

AU - Jelenkovic, A.

AU - Sund, R.

AU - Hur, Y.M.

AU - Yokoyama, Y.

AU - Hjelmborg, J.

AU - Möller, S.

AU - Honda, C.

AU - Magnusson, P.K.E.

AU - Pedersen, N.L.

AU - Ooki, S.

AU - Aaltonen, S.

AU - Stazi, M.A.

AU - Fagnani, C.

AU - D'Ippolito, C.

AU - Freitas, D.L.

AU - Antonio Maia, D.

AU - Ji, F.

AU - Ning, F.

AU - Pang, Z.

AU - Rebato, E.

AU - Busjahn, A.

AU - Kandler, C.

AU - Saudino, K.J.

AU - Jang, K.L.

AU - Cozen, W.

AU - Hwang, A.E.

AU - Mack, T.M.

AU - Gao, W.

AU - Yu, C.

AU - Li, L.

AU - Corley, R.P.

AU - Huibregtse, B.M.

AU - Derom, C.A.

AU - Vlietinck, R.F.

AU - Loos, R.J.F.

AU - Heikkilä, K.

AU - Wardle, J.

AU - Llewellyn, C.H.

AU - Fisher, A.

AU - McAdams, T.A.

AU - Eley, T.C.

AU - Gregory, A.M.

AU - He, M.

AU - Ding, X.

AU - Bjerregaard-Andersen, M.

AU - Beck-Nielsen, H.

AU - Sodemann, M.

AU - Tarnoki, A.D.

AU - Tarnoki, D.L.

AU - Knafo-Noam, A.

AU - Mankuta, D.

AU - Abramson, L.

AU - Burt, S.A.

AU - Klump, K.L.

AU - Silberg, J.L.

AU - Eaves, L.J.

AU - Maes, H.H.

AU - Krueger, R.F.

AU - McGue, M.

AU - Pahlen, S.

AU - Gatz, M.

AU - Butler, D.A.

AU - Bartels, M.

AU - van Beijsterveldt, C.E.M.

AU - Craig, J.M.

AU - Saffery, R.

AU - Dubois, L.

AU - Boivin, M.

AU - Brendgen, M.

AU - Dionne, G.

AU - Vitaro, F.

AU - Martin, N.G.

AU - Medland, S.E.

AU - Montgomery, G.W.

AU - Swan, G.E.

AU - Krasnow, R.

AU - Tynelius, P.

AU - Lichtenstein, P.

AU - Haworth, C.M.A.

AU - Plomin, R.

AU - Bayasgalan, G.

AU - Narandalai, D.

AU - Harden, K.P.

AU - Tucker-Drob, E.M.

AU - Spector, T.D.

AU - Mangino, M.

AU - Lachance, G.

AU - Baker, L.A.

AU - Tuvblad, C.

AU - Duncan, G.E.

AU - Buchwald, D.

AU - Willemsen, G.

AU - Skytthe, A.

AU - Kyvik, K.O.

AU - Christensen, K.

AU - Öncel, S.Y.

AU - Aliev, F.

AU - Rasmussen, F.

AU - Goldberg, J.H.

AU - Sørensen, T.I.A.

AU - Boomsma, D.I.

AU - Kaprio, J.

AU - Silventoinen, K.

PY - 2016

Y1 - 2016

N2 - Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

AB - Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

U2 - 10.1038/srep28496

DO - 10.1038/srep28496

M3 - Article

VL - 6

SP - 1

EP - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 28496

ER -

Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Abstract

Cohort Studies

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