Genetic control of functional brain network efficiency in children

M.P. Heuvel; I.L.C. van Soelen; C.J. Stam; R.S. Kahn; D.I. Boomsma; H.E. Hulshoff Pol

doi:10.1016/j.euroneuro.2012.06.007

Genetic control of functional brain network efficiency in children

M.P. Heuvel
, I.L.C. van Soelen
, C.J. Stam
, R.S. Kahn
, D.I. Boomsma
, H.E. Hulshoff Pol

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence. However, the extent to which genes influence the functional brain network early in development is not yet known. We report on the heritability of functional brain efficiency during early brain development. Using a twin design, young children underwent resting-state functional magnetic resonance imaging brain scans (N=86 from 21MZ and 22DZ twin-pairs, age=12 years). Functional connectivity, defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions, was explored using graph theory and its heritability was examined using structural equation modeling. Our findings suggest that 'global efficiency of communication' among brain regions is under genetic control (h

Original language	English
Pages (from-to)	19-23
Journal	European Neuropsychopharmacology
Volume	23
Issue number	1
Early online date	23 Jul 2012
DOIs	https://doi.org/10.1016/j.euroneuro.2012.06.007
Publication status	Published - 2013

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1016/j.euroneuro.2012.06.007

Persistent URL (handle)

Persistent link

Cite this

@article{174bc0fdb0ae4f01bd631ed4001727f9,

title = "Genetic control of functional brain network efficiency in children",

abstract = "The human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence. However, the extent to which genes influence the functional brain network early in development is not yet known. We report on the heritability of functional brain efficiency during early brain development. Using a twin design, young children underwent resting-state functional magnetic resonance imaging brain scans (N=86 from 21MZ and 22DZ twin-pairs, age=12 years). Functional connectivity, defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions, was explored using graph theory and its heritability was examined using structural equation modeling. Our findings suggest that 'global efficiency of communication' among brain regions is under genetic control (h",

author = "M.P. Heuvel and \{van Soelen\}, I.L.C. and C.J. Stam and R.S. Kahn and D.I. Boomsma and \{Hulshoff Pol\}, H.E.",

year = "2013",

doi = "10.1016/j.euroneuro.2012.06.007",

language = "English",

volume = "23",

pages = "19--23",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Genetic control of functional brain network efficiency in children

AU - Heuvel, M.P.

AU - van Soelen, I.L.C.

AU - Stam, C.J.

AU - Kahn, R.S.

AU - Boomsma, D.I.

AU - Hulshoff Pol, H.E.

PY - 2013

Y1 - 2013

N2 - The human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence. However, the extent to which genes influence the functional brain network early in development is not yet known. We report on the heritability of functional brain efficiency during early brain development. Using a twin design, young children underwent resting-state functional magnetic resonance imaging brain scans (N=86 from 21MZ and 22DZ twin-pairs, age=12 years). Functional connectivity, defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions, was explored using graph theory and its heritability was examined using structural equation modeling. Our findings suggest that 'global efficiency of communication' among brain regions is under genetic control (h

AB - The human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence. However, the extent to which genes influence the functional brain network early in development is not yet known. We report on the heritability of functional brain efficiency during early brain development. Using a twin design, young children underwent resting-state functional magnetic resonance imaging brain scans (N=86 from 21MZ and 22DZ twin-pairs, age=12 years). Functional connectivity, defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions, was explored using graph theory and its heritability was examined using structural equation modeling. Our findings suggest that 'global efficiency of communication' among brain regions is under genetic control (h

U2 - 10.1016/j.euroneuro.2012.06.007

DO - 10.1016/j.euroneuro.2012.06.007

M3 - Article

SN - 0924-977X

VL - 23

SP - 19

EP - 23

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 1

ER -

Genetic control of functional brain network efficiency in children

Abstract

Cohort Studies

Access to Document

Persistent URL (handle)

Fingerprint

Cite this