Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed

D. Posthuma; W.F.C. Baare; H.E. Hulshoff Pol; R.S. Kahn; D.I. Boomsma; E.J.C. de Geus

doi:10.1375/136905203321536254

Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed

D. Posthuma, W.F.C. Baare, H.E. Hulshoff Pol, R.S. Kahn, D.I. Boomsma, E.J.C. de Geus

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

228 Downloads (Pure)

Abstract

We recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors (Posthuma et al., 2002). Here we examine whether the other WAIS III dimensions (Verbal Comprehension, Perceptual Organization, Processing Speed) are also related to gray and white matter volume, and whether any of the dimensions are related to cerebellar volume. Two overlapping samples provided 135 subjects from 60 extended twin families for whom both MRI scans and WAIS III data were available. All three brain volumes are related to Working Memory capacity (r = 0.27). This phenotypic correlation is completely due to a common underlying genetic factor. Processing Speed was genetically related to white matter volume (r

Original language	English
Pages (from-to)	131-139
Journal	Twin Research
Volume	6
Issue number	2
DOIs	https://doi.org/10.1375/136905203321536254
Publication status	Published - 2003

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1375/136905203321536254

Posthuma Twin Research 6(2) 2003 uFinal published version, 156 KB

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR_publicaties/Posthuma_TR2003_BrainIQ.pdf

Handle.net

Persistent link

Cite this

@article{336b43d587424732a3fc9af2815b5d8c,

title = "Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed",

abstract = "We recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors (Posthuma et al., 2002). Here we examine whether the other WAIS III dimensions (Verbal Comprehension, Perceptual Organization, Processing Speed) are also related to gray and white matter volume, and whether any of the dimensions are related to cerebellar volume. Two overlapping samples provided 135 subjects from 60 extended twin families for whom both MRI scans and WAIS III data were available. All three brain volumes are related to Working Memory capacity (r = 0.27). This phenotypic correlation is completely due to a common underlying genetic factor. Processing Speed was genetically related to white matter volume (r",

author = "D. Posthuma and W.F.C. Baare and {Hulshoff Pol}, H.E. and R.S. Kahn and D.I. Boomsma and {de Geus}, E.J.C.",

year = "2003",

doi = "10.1375/136905203321536254",

language = "English",

volume = "6",

pages = "131--139",

journal = "Twin Research",

issn = "1369-0523",

publisher = "Australian Academic Press",

number = "2",

}

TY - JOUR

T1 - Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed

AU - Posthuma, D.

AU - Baare, W.F.C.

AU - Hulshoff Pol, H.E.

AU - Kahn, R.S.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

PY - 2003

Y1 - 2003

N2 - We recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors (Posthuma et al., 2002). Here we examine whether the other WAIS III dimensions (Verbal Comprehension, Perceptual Organization, Processing Speed) are also related to gray and white matter volume, and whether any of the dimensions are related to cerebellar volume. Two overlapping samples provided 135 subjects from 60 extended twin families for whom both MRI scans and WAIS III data were available. All three brain volumes are related to Working Memory capacity (r = 0.27). This phenotypic correlation is completely due to a common underlying genetic factor. Processing Speed was genetically related to white matter volume (r

AB - We recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors (Posthuma et al., 2002). Here we examine whether the other WAIS III dimensions (Verbal Comprehension, Perceptual Organization, Processing Speed) are also related to gray and white matter volume, and whether any of the dimensions are related to cerebellar volume. Two overlapping samples provided 135 subjects from 60 extended twin families for whom both MRI scans and WAIS III data were available. All three brain volumes are related to Working Memory capacity (r = 0.27). This phenotypic correlation is completely due to a common underlying genetic factor. Processing Speed was genetically related to white matter volume (r

U2 - 10.1375/136905203321536254

DO - 10.1375/136905203321536254

M3 - Article

VL - 6

SP - 131

EP - 139

JO - Twin Research

JF - Twin Research

SN - 1369-0523

IS - 2

ER -

Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed

Abstract

Cohort Studies

Access to Document

Handle.net

Fingerprint

Cite this