Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

A. Moayyeri, Y.H. Hsu, D. Karasik, K. Estrada, S.M. Xiao, C. Nielson, P. Srikanth, S. Giroux, S.G. Wilson, H.F. Zheng, A.V. Smith, S.R. Pye, P.J. Leo, A. Teumer, J.Y. Hwang, C. Ohlsson, F. McGuigan, R.L. Minster, C. Hayward, J.M. OlmosL.P. Lyytikainen, J.R. Lewis, K.M.A. Swart, L. Masi, C. Oldmeadow, E.G. Holliday, S.L. Cheng, N.M. van Schoor, N.C. Harvey, M. Kruk, M. Fabiola Del Greco, W. Igl, O. Trummer, E. Grigoriou, R. Luben, C.T. Liu, Y.H. Zhou, L. Oei, C. Medina-Gomez, J. Zmuda, G. Tranah, S.J. Brown, F.M. Williams, N. Soranzo, J. Jakobsdottir, K. Siggeirsdottir, K.L. Holliday, A. Hannemann, M.J. Go, M. Garcia, O. Polasek, M. Laaksonen, K. Zhu, A.W. Enneman, M. McEvoy, R. Peel, P.C. Sham, M. Jaworski, A. Johansson, A.A. Hicks, P. Pludowski, R. Scott, R.A.M. Dhonukshe-Rutten, N. van der Velde, M. Kahonen, J.S. Viikari, H. Sievanen, O.T. Raitakari, J. Gonzalez-Macias, J.L. Hernandez, D. Mellstroom, O. Ljunggren, Y.S. Cho, U. Volker, M. Nauck, G. Homuth, H. Volzke, R. Haring, M. A. Brown, E. McCloskey, G.C. Nicholson, R. Eastell, J.A. Eisman, G. Jones, I.R. Reid, E.M. Dennison, J. Wark, S. Boonen, D. Vanderschueren, F.C.W. Wu, T. Aspelund, J.B. Richards, D. Bauer, A. Hofman, K.T. Khaw, G. Dedoussis, B. Obermayer-Pietsch, U. Gyllensten, P.P. Pramstaller, R.S. Lorenc, C. Cooper, A.W.C. Kung, P.T.A.M. Lips, J. Reeve, S.K. Kaptoge

    Research output: Contribution to JournalArticleAcademicpeer-review


    Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n 5 14 260), velocity of sound (VOS; n 5 15 514) and BMD (n 5 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n 5 11 452) and new genotyping in 15 cohorts (de novo n 5 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 3 10
    Original languageEnglish
    Pages (from-to)3054-3068
    JournalHuman Molecular Genetics
    Issue number11
    Publication statusPublished - 2014


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