Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

A. Moayyeri; Y.H. Hsu; D. Karasik; K. Estrada; S.M. Xiao; C. Nielson; P. Srikanth; S. Giroux; S.G. Wilson; H.F. Zheng; A.V. Smith; S.R. Pye; P.J. Leo; A. Teumer; J.Y. Hwang; C. Ohlsson; F. McGuigan; R.L. Minster; C. Hayward; J.M. Olmos; L.P. Lyytikainen; J.R. Lewis; K.M.A. Swart; L. Masi; C. Oldmeadow; E.G. Holliday; S.L. Cheng; N.M. van Schoor; N.C. Harvey; M. Kruk; M. Fabiola Del Greco; W. Igl; O. Trummer; E. Grigoriou; R. Luben; C.T. Liu; Y.H. Zhou; L. Oei; C. Medina-Gomez; J. Zmuda; G. Tranah; S.J. Brown; F.M. Williams; N. Soranzo; J. Jakobsdottir; K. Siggeirsdottir; K.L. Holliday; A. Hannemann; M.J. Go; M. Garcia; O. Polasek; M. Laaksonen; K. Zhu; A.W. Enneman; M. McEvoy; R. Peel; P.C. Sham; M. Jaworski; A. Johansson; A.A. Hicks; P. Pludowski; R. Scott; R.A.M. Dhonukshe-Rutten; N. van der Velde; M. Kahonen; J.S. Viikari; H. Sievanen; O.T. Raitakari; J. Gonzalez-Macias; J.L. Hernandez; D. Mellstroom; O. Ljunggren; Y.S. Cho; U. Volker; M. Nauck; G. Homuth; H. Volzke; R. Haring; M. A. Brown; E. McCloskey; G.C. Nicholson; R. Eastell; J.A. Eisman; G. Jones; I.R. Reid; E.M. Dennison; J. Wark; S. Boonen; D. Vanderschueren; F.C.W. Wu; T. Aspelund; J.B. Richards; D. Bauer; A. Hofman; K.T. Khaw; G. Dedoussis; B. Obermayer-Pietsch; U. Gyllensten; P.P. Pramstaller; R.S. Lorenc; C. Cooper; A.W.C. Kung; P.T.A.M. Lips; J. Reeve; S.K. Kaptoge

doi:10.1093/hmg/ddt675

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

A. Moayyeri, Y.H. Hsu, D. Karasik, K. Estrada, S.M. Xiao, C. Nielson, P. Srikanth, S. Giroux, S.G. Wilson, H.F. Zheng, A.V. Smith, S.R. Pye, P.J. Leo, A. Teumer, J.Y. Hwang, C. Ohlsson, F. McGuigan, R.L. Minster, C. Hayward, J.M. OlmosL.P. Lyytikainen, J.R. Lewis, K.M.A. Swart, L. Masi, C. Oldmeadow, E.G. Holliday, S.L. Cheng, N.M. van Schoor, N.C. Harvey, M. Kruk, M. Fabiola Del Greco, W. Igl, O. Trummer, E. Grigoriou, R. Luben, C.T. Liu, Y.H. Zhou, L. Oei, C. Medina-Gomez, J. Zmuda, G. Tranah, S.J. Brown, F.M. Williams, N. Soranzo, J. Jakobsdottir, K. Siggeirsdottir, K.L. Holliday, A. Hannemann, M.J. Go, M. Garcia, O. Polasek, M. Laaksonen, K. Zhu, A.W. Enneman, M. McEvoy, R. Peel, P.C. Sham, M. Jaworski, A. Johansson, A.A. Hicks, P. Pludowski, R. Scott, R.A.M. Dhonukshe-Rutten, N. van der Velde, M. Kahonen, J.S. Viikari, H. Sievanen, O.T. Raitakari, J. Gonzalez-Macias, J.L. Hernandez, D. Mellstroom, O. Ljunggren, Y.S. Cho, U. Volker, M. Nauck, G. Homuth, H. Volzke, R. Haring, M. A. Brown, E. McCloskey, G.C. Nicholson, R. Eastell, J.A. Eisman, G. Jones, I.R. Reid, E.M. Dennison, J. Wark, S. Boonen, D. Vanderschueren, F.C.W. Wu, T. Aspelund, J.B. Richards, D. Bauer, A. Hofman, K.T. Khaw, G. Dedoussis, B. Obermayer-Pietsch, U. Gyllensten, P.P. Pramstaller, R.S. Lorenc, C. Cooper, A.W.C. Kung, P.T.A.M. Lips, J. Reeve, S.K. Kaptoge

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n 5 14 260), velocity of sound (VOS; n 5 15 514) and BMD (n 5 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n 5 11 452) and new genotyping in 15 cohorts (de novo n 5 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 3 10

Original language	English
Pages (from-to)	3054-3068
Journal	Human Molecular Genetics
Volume	23
Issue number	11
DOIs	https://doi.org/10.1093/hmg/ddt675
Publication status	Published - 2014

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10.1093/hmg/ddt675

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Moayyeri, A., Hsu, Y. H., Karasik, D., Estrada, K., Xiao, S. M., Nielson, C., Srikanth, P., Giroux, S., Wilson, S. G., Zheng, H. F., Smith, A. V., Pye, S. R., Leo, P. J., Teumer, A., Hwang, J. Y., Ohlsson, C., McGuigan, F., Minster, R. L., Hayward, C., ... Kaptoge, S. K. (2014). Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Human Molecular Genetics, 23(11), 3054-3068. https://doi.org/10.1093/hmg/ddt675

@article{347db46fcbb34dfbac8b2bd396533e2e,

title = "Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium",

abstract = "Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n 5 14 260), velocity of sound (VOS; n 5 15 514) and BMD (n 5 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n 5 11 452) and new genotyping in 15 cohorts (de novo n 5 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 3 10",

author = "A. Moayyeri and Y.H. Hsu and D. Karasik and K. Estrada and S.M. Xiao and C. Nielson and P. Srikanth and S. Giroux and S.G. Wilson and H.F. Zheng and A.V. Smith and S.R. Pye and P.J. Leo and A. Teumer and J.Y. Hwang and C. Ohlsson and F. McGuigan and R.L. Minster and C. Hayward and J.M. Olmos and L.P. Lyytikainen and J.R. Lewis and K.M.A. Swart and L. Masi and C. Oldmeadow and E.G. Holliday and S.L. Cheng and {van Schoor}, N.M. and N.C. Harvey and M. Kruk and {Fabiola Del Greco}, M. and W. Igl and O. Trummer and E. Grigoriou and R. Luben and C.T. Liu and Y.H. Zhou and L. Oei and C. Medina-Gomez and J. Zmuda and G. Tranah and S.J. Brown and F.M. Williams and N. Soranzo and J. Jakobsdottir and K. Siggeirsdottir and K.L. Holliday and A. Hannemann and M.J. Go and M. Garcia and O. Polasek and M. Laaksonen and K. Zhu and A.W. Enneman and M. McEvoy and R. Peel and P.C. Sham and M. Jaworski and A. Johansson and A.A. Hicks and P. Pludowski and R. Scott and R.A.M. Dhonukshe-Rutten and {van der Velde}, N. and M. Kahonen and J.S. Viikari and H. Sievanen and O.T. Raitakari and J. Gonzalez-Macias and J.L. Hernandez and D. Mellstroom and O. Ljunggren and Y.S. Cho and U. Volker and M. Nauck and G. Homuth and H. Volzke and R. Haring and Brown, {M. A.} and E. McCloskey and G.C. Nicholson and R. Eastell and J.A. Eisman and G. Jones and I.R. Reid and E.M. Dennison and J. Wark and S. Boonen and D. Vanderschueren and F.C.W. Wu and T. Aspelund and J.B. Richards and D. Bauer and A. Hofman and K.T. Khaw and G. Dedoussis and B. Obermayer-Pietsch and U. Gyllensten and P.P. Pramstaller and R.S. Lorenc and C. Cooper and A.W.C. Kung and P.T.A.M. Lips and J. Reeve and S.K. Kaptoge",

year = "2014",

doi = "10.1093/hmg/ddt675",

language = "English",

volume = "23",

pages = "3054--3068",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "11",

}

Moayyeri, A, Hsu, YH, Karasik, D, Estrada, K, Xiao, SM, Nielson, C, Srikanth, P, Giroux, S, Wilson, SG, Zheng, HF, Smith, AV, Pye, SR, Leo, PJ, Teumer, A, Hwang, JY, Ohlsson, C, McGuigan, F, Minster, RL, Hayward, C, Olmos, JM, Lyytikainen, LP, Lewis, JR, Swart, KMA, Masi, L, Oldmeadow, C, Holliday, EG, Cheng, SL, van Schoor, NM, Harvey, NC, Kruk, M, Fabiola Del Greco, M, Igl, W, Trummer, O, Grigoriou, E, Luben, R, Liu, CT, Zhou, YH, Oei, L, Medina-Gomez, C, Zmuda, J, Tranah, G, Brown, SJ, Williams, FM, Soranzo, N, Jakobsdottir, J, Siggeirsdottir, K, Holliday, KL, Hannemann, A, Go, MJ, Garcia, M, Polasek, O, Laaksonen, M, Zhu, K, Enneman, AW, McEvoy, M, Peel, R, Sham, PC, Jaworski, M, Johansson, A, Hicks, AA, Pludowski, P, Scott, R, Dhonukshe-Rutten, RAM, van der Velde, N, Kahonen, M, Viikari, JS, Sievanen, H, Raitakari, OT, Gonzalez-Macias, J, Hernandez, JL, Mellstroom, D, Ljunggren, O, Cho, YS, Volker, U, Nauck, M, Homuth, G, Volzke, H, Haring, R, Brown, MA, McCloskey, E, Nicholson, GC, Eastell, R, Eisman, JA, Jones, G, Reid, IR, Dennison, EM, Wark, J, Boonen, S, Vanderschueren, D, Wu, FCW, Aspelund, T, Richards, JB, Bauer, D, Hofman, A, Khaw, KT, Dedoussis, G, Obermayer-Pietsch, B, Gyllensten, U, Pramstaller, PP, Lorenc, RS, Cooper, C, Kung, AWC, Lips, PTAM, Reeve, J & Kaptoge, SK 2014, 'Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium', Human Molecular Genetics, vol. 23, no. 11, pp. 3054-3068. https://doi.org/10.1093/hmg/ddt675

TY - JOUR

T1 - Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

AU - Moayyeri, A.

AU - Hsu, Y.H.

AU - Karasik, D.

AU - Estrada, K.

AU - Xiao, S.M.

AU - Nielson, C.

AU - Srikanth, P.

AU - Giroux, S.

AU - Wilson, S.G.

AU - Zheng, H.F.

AU - Smith, A.V.

AU - Pye, S.R.

AU - Leo, P.J.

AU - Teumer, A.

AU - Hwang, J.Y.

AU - Ohlsson, C.

AU - McGuigan, F.

AU - Minster, R.L.

AU - Hayward, C.

AU - Olmos, J.M.

AU - Lyytikainen, L.P.

AU - Lewis, J.R.

AU - Swart, K.M.A.

AU - Masi, L.

AU - Oldmeadow, C.

AU - Holliday, E.G.

AU - Cheng, S.L.

AU - van Schoor, N.M.

AU - Harvey, N.C.

AU - Kruk, M.

AU - Fabiola Del Greco, M.

AU - Igl, W.

AU - Trummer, O.

AU - Grigoriou, E.

AU - Luben, R.

AU - Liu, C.T.

AU - Zhou, Y.H.

AU - Oei, L.

AU - Medina-Gomez, C.

AU - Zmuda, J.

AU - Tranah, G.

AU - Brown, S.J.

AU - Williams, F.M.

AU - Soranzo, N.

AU - Jakobsdottir, J.

AU - Siggeirsdottir, K.

AU - Holliday, K.L.

AU - Hannemann, A.

AU - Go, M.J.

AU - Garcia, M.

AU - Polasek, O.

AU - Laaksonen, M.

AU - Zhu, K.

AU - Enneman, A.W.

AU - McEvoy, M.

AU - Peel, R.

AU - Sham, P.C.

AU - Jaworski, M.

AU - Johansson, A.

AU - Hicks, A.A.

AU - Pludowski, P.

AU - Scott, R.

AU - Dhonukshe-Rutten, R.A.M.

AU - van der Velde, N.

AU - Kahonen, M.

AU - Viikari, J.S.

AU - Sievanen, H.

AU - Raitakari, O.T.

AU - Gonzalez-Macias, J.

AU - Hernandez, J.L.

AU - Mellstroom, D.

AU - Ljunggren, O.

AU - Cho, Y.S.

AU - Volker, U.

AU - Nauck, M.

AU - Homuth, G.

AU - Volzke, H.

AU - Haring, R.

AU - Brown, M. A.

AU - McCloskey, E.

AU - Nicholson, G.C.

AU - Eastell, R.

AU - Eisman, J.A.

AU - Jones, G.

AU - Reid, I.R.

AU - Dennison, E.M.

AU - Wark, J.

AU - Boonen, S.

AU - Vanderschueren, D.

AU - Wu, F.C.W.

AU - Aspelund, T.

AU - Richards, J.B.

AU - Bauer, D.

AU - Hofman, A.

AU - Khaw, K.T.

AU - Dedoussis, G.

AU - Obermayer-Pietsch, B.

AU - Gyllensten, U.

AU - Pramstaller, P.P.

AU - Lorenc, R.S.

AU - Cooper, C.

AU - Kung, A.W.C.

AU - Lips, P.T.A.M.

AU - Reeve, J.

AU - Kaptoge, S.K.

PY - 2014

Y1 - 2014

N2 - Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n 5 14 260), velocity of sound (VOS; n 5 15 514) and BMD (n 5 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n 5 11 452) and new genotyping in 15 cohorts (de novo n 5 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 3 10

AB - Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n 5 14 260), velocity of sound (VOS; n 5 15 514) and BMD (n 5 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n 5 11 452) and new genotyping in 15 cohorts (de novo n 5 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 3 10

U2 - 10.1093/hmg/ddt675

DO - 10.1093/hmg/ddt675

M3 - Article

SN - 0964-6906

VL - 23

SP - 3054

EP - 3068

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 11

ER -

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

Abstract

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