Genetic factors account for most of the variation in serum tryptase--a twin study

A. Sverrild, S. van der Sluis, K.O. Kyvik, L.H. Garvey, C. Porsbjerg, V. Backer, S.F. Thomsen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background Mast cells are involved in a number of diseases, including inflammatory diseases such as asthma. Tryptase is a known marker of mast cell burden and activity. However, little is known about the genetic influence on serum tryptase variation. Also, only few and conflicting data exist on serum tryptase in asthma. Objective To estimate the overall contribution of genetic and environmental factors to the variation in serum tryptase and to examine the correlation between serum tryptase and asthma, rhinitis, markers of allergy, airway inflammation, and airway hyperresponsiveness (AHR) in a sample of Danish twins. Methods A total of 575 twins underwent a skin prick test and had lung function, AHR to methacholine, exhaled nitric oxide and serum tryptase measured. Multiple regression and variance components models (using the statistical package SOLAR) were computed. Results Serum tryptase values were available in 569 subjects. Intraclass correlations of serum tryptase in monozygotic and dizygotic twin pairs were 0.84 and 0.42 (P <.001). Variance decomposition showed that genetic factors accounted for 82% (95% confidence interval 74-90, P <.001) of the variation in serum tryptase. Body mass index and sex, but not asthma, rhinitis, or AHR, were correlated to serum tryptase. Conclusion As much as 82% of the variation in serum tryptase is due to genetic factors. Body mass index and sex, but not asthma or AHR to methacholine, correlate to serum tryptase. A genetic overlap may exist between serum tryptase and body mass index. © 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)286-289
JournalAnnals of Allergy Asthma and Immunology
Volume111
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Tryptases
Twin Studies
Serum
Asthma
Body Mass Index
Methacholine Chloride
Rhinitis
Mast Cells
Hypersensitivity
Dizygotic Twins
Monozygotic Twins
Statistical Models
Allergy and Immunology
Skin Tests

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Sverrild, A. ; van der Sluis, S. ; Kyvik, K.O. ; Garvey, L.H. ; Porsbjerg, C. ; Backer, V. ; Thomsen, S.F. / Genetic factors account for most of the variation in serum tryptase--a twin study. In: Annals of Allergy Asthma and Immunology. 2013 ; Vol. 111, No. 4. pp. 286-289.
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abstract = "Background Mast cells are involved in a number of diseases, including inflammatory diseases such as asthma. Tryptase is a known marker of mast cell burden and activity. However, little is known about the genetic influence on serum tryptase variation. Also, only few and conflicting data exist on serum tryptase in asthma. Objective To estimate the overall contribution of genetic and environmental factors to the variation in serum tryptase and to examine the correlation between serum tryptase and asthma, rhinitis, markers of allergy, airway inflammation, and airway hyperresponsiveness (AHR) in a sample of Danish twins. Methods A total of 575 twins underwent a skin prick test and had lung function, AHR to methacholine, exhaled nitric oxide and serum tryptase measured. Multiple regression and variance components models (using the statistical package SOLAR) were computed. Results Serum tryptase values were available in 569 subjects. Intraclass correlations of serum tryptase in monozygotic and dizygotic twin pairs were 0.84 and 0.42 (P <.001). Variance decomposition showed that genetic factors accounted for 82{\%} (95{\%} confidence interval 74-90, P <.001) of the variation in serum tryptase. Body mass index and sex, but not asthma, rhinitis, or AHR, were correlated to serum tryptase. Conclusion As much as 82{\%} of the variation in serum tryptase is due to genetic factors. Body mass index and sex, but not asthma or AHR to methacholine, correlate to serum tryptase. A genetic overlap may exist between serum tryptase and body mass index. {\circledC} 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.",
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Genetic factors account for most of the variation in serum tryptase--a twin study. / Sverrild, A.; van der Sluis, S.; Kyvik, K.O.; Garvey, L.H.; Porsbjerg, C.; Backer, V.; Thomsen, S.F.

In: Annals of Allergy Asthma and Immunology, Vol. 111, No. 4, 2013, p. 286-289.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Genetic factors account for most of the variation in serum tryptase--a twin study

AU - Sverrild, A.

AU - van der Sluis, S.

AU - Kyvik, K.O.

AU - Garvey, L.H.

AU - Porsbjerg, C.

AU - Backer, V.

AU - Thomsen, S.F.

PY - 2013

Y1 - 2013

N2 - Background Mast cells are involved in a number of diseases, including inflammatory diseases such as asthma. Tryptase is a known marker of mast cell burden and activity. However, little is known about the genetic influence on serum tryptase variation. Also, only few and conflicting data exist on serum tryptase in asthma. Objective To estimate the overall contribution of genetic and environmental factors to the variation in serum tryptase and to examine the correlation between serum tryptase and asthma, rhinitis, markers of allergy, airway inflammation, and airway hyperresponsiveness (AHR) in a sample of Danish twins. Methods A total of 575 twins underwent a skin prick test and had lung function, AHR to methacholine, exhaled nitric oxide and serum tryptase measured. Multiple regression and variance components models (using the statistical package SOLAR) were computed. Results Serum tryptase values were available in 569 subjects. Intraclass correlations of serum tryptase in monozygotic and dizygotic twin pairs were 0.84 and 0.42 (P <.001). Variance decomposition showed that genetic factors accounted for 82% (95% confidence interval 74-90, P <.001) of the variation in serum tryptase. Body mass index and sex, but not asthma, rhinitis, or AHR, were correlated to serum tryptase. Conclusion As much as 82% of the variation in serum tryptase is due to genetic factors. Body mass index and sex, but not asthma or AHR to methacholine, correlate to serum tryptase. A genetic overlap may exist between serum tryptase and body mass index. © 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

AB - Background Mast cells are involved in a number of diseases, including inflammatory diseases such as asthma. Tryptase is a known marker of mast cell burden and activity. However, little is known about the genetic influence on serum tryptase variation. Also, only few and conflicting data exist on serum tryptase in asthma. Objective To estimate the overall contribution of genetic and environmental factors to the variation in serum tryptase and to examine the correlation between serum tryptase and asthma, rhinitis, markers of allergy, airway inflammation, and airway hyperresponsiveness (AHR) in a sample of Danish twins. Methods A total of 575 twins underwent a skin prick test and had lung function, AHR to methacholine, exhaled nitric oxide and serum tryptase measured. Multiple regression and variance components models (using the statistical package SOLAR) were computed. Results Serum tryptase values were available in 569 subjects. Intraclass correlations of serum tryptase in monozygotic and dizygotic twin pairs were 0.84 and 0.42 (P <.001). Variance decomposition showed that genetic factors accounted for 82% (95% confidence interval 74-90, P <.001) of the variation in serum tryptase. Body mass index and sex, but not asthma, rhinitis, or AHR, were correlated to serum tryptase. Conclusion As much as 82% of the variation in serum tryptase is due to genetic factors. Body mass index and sex, but not asthma or AHR to methacholine, correlate to serum tryptase. A genetic overlap may exist between serum tryptase and body mass index. © 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

U2 - 10.1016/j.anai.2013.07.011

DO - 10.1016/j.anai.2013.07.011

M3 - Article

VL - 111

SP - 286

EP - 289

JO - Annals of Allergy Asthma and Immunology

JF - Annals of Allergy Asthma and Immunology

SN - 1081-1206

IS - 4

ER -