Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group

Rachel M Brouwer; Matthew S Panizzon; David C Glahn; Derrek P Hibar; Xue Hua; Neda Jahanshad; Lucija Abramovic; Greig I De Zubicaray; Carol E Franz; Narelle K Hansell; Ian B Hickie; Marinka M G Koenis; Nicholas G Martin; Karen A Mather; Katie L McMahon; Hugo G Schnack; Lachlan T Strike; Suzanne C Swagerman; Anbupalam Thalamuthu; Wei Wen; John H Gilmore; Nitin Gogtay; René S Kahn; Perminder S Sachdev; Margaret J Wright; Dorret I Boomsma; William S Kremen; Paul M Thompson; Hilleke E Hulshoff Pol

doi:10.1002/hbm.23672

Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group

Rachel M Brouwer, Matthew S Panizzon, David C Glahn, Derrek P Hibar, Xue Hua, Neda Jahanshad, Lucija Abramovic, Greig I De Zubicaray, Carol E Franz, Narelle K Hansell, Ian B Hickie, Marinka M G Koenis, Nicholas G Martin, Karen A Mather, Katie L McMahon, Hugo G Schnack, Lachlan T Strike, Suzanne C Swagerman, Anbupalam Thalamuthu, Wei WenJohn H Gilmore, Nitin Gogtay, René S Kahn, Perminder S Sachdev, Margaret J Wright, Dorret I Boomsma, William S Kremen, Paul M Thompson, Hilleke E Hulshoff Pol

Research output: Contribution to Journal › Article › Academic › peer-review

13 Downloads (Pure)

Abstract

Structural brain changes that occur during development and ageing are related to mental health and general cognitive functioning. Individuals differ in the extent to which their brain volumes change over time, but whether these differences can be attributed to differences in their genotypes has not been widely studied. Here we estimate heritability (h(2) ) of changes in global and subcortical brain volumes in five longitudinal twin cohorts from across the world and in different stages of the lifespan (N = 861). Heritability estimates of brain changes were significant and ranged from 16% (caudate) to 42% (cerebellar gray matter) for all global and most subcortical volumes (with the exception of thalamus and pallidum). Heritability estimates of change rates were generally higher in adults than in children suggesting an increasing influence of genetic factors explaining individual differences in brain structural changes with age. In children, environmental influences in part explained individual differences in developmental changes in brain structure. Multivariate genetic modeling showed that genetic influences of change rates and baseline volume significantly overlapped for many structures. The genetic influences explaining individual differences in the change rate for cerebellum, cerebellar gray matter and lateral ventricles were independent of the genetic influences explaining differences in their baseline volumes. These results imply the existence of genetic variants that are specific for brain plasticity, rather than brain volume itself. Identifying these genes may increase our understanding of brain development and ageing and possibly have implications for diseases that are characterized by deviant developmental trajectories of brain structure. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	4444-4458
Number of pages	15
Journal	Human Brain Mapping
Volume	38
Issue number	9
Early online date	5 Jun 2017
DOIs	https://doi.org/10.1002/hbm.23672
Publication status	Published - Sept 2017

Funding

BrainSCALE and Utwins1 We thank all the participating families. QTIM: We are grateful to the twins for their generosity of time and willingness to participate in our studies. We thank research assistants Marlene Grace, Ann Eldridge, and Kerrie McAloney, radiographers Aiman Al Najjar and Anita Burns for acquisition of the scans, and David Smyth, Anthony Conciatore, Daniel Park, and David Butler for IT support. OATS: We gratefully acknowledge and thank the OATS participants and the OATS research team. OATS was facilitated through access to the Australian Twin Registry, which is administered by Melbourne University.

Funders	Funder number
Kerrie McAloney
National Institute on Aging	R01AG022982
University of Melbourne

Keywords

Journal Article

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1002/hbm.23672

2017 - Brouwer - Genetic influences on individual differences in longitudinal changes in global andFinal published version, 696 KBLicence: Article 25fa Dutch Copyright Act

Persistent URL (handle)

Persistent link

Cite this

Brouwer, R. M., Panizzon, M. S., Glahn, D. C., Hibar, D. P., Hua, X., Jahanshad, N., Abramovic, L., De Zubicaray, G. I., Franz, C. E., Hansell, N. K., Hickie, I. B., Koenis, M. M. G., Martin, N. G., Mather, K. A., McMahon, K. L., Schnack, H. G., Strike, L. T., Swagerman, S. C., Thalamuthu, A., ... Hulshoff Pol, H. E. (2017). Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human Brain Mapping, 38(9), 4444-4458. https://doi.org/10.1002/hbm.23672

@article{16031cebcc574486b708575ca1835b16,

title = "Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group",

abstract = "Structural brain changes that occur during development and ageing are related to mental health and general cognitive functioning. Individuals differ in the extent to which their brain volumes change over time, but whether these differences can be attributed to differences in their genotypes has not been widely studied. Here we estimate heritability (h(2) ) of changes in global and subcortical brain volumes in five longitudinal twin cohorts from across the world and in different stages of the lifespan (N = 861). Heritability estimates of brain changes were significant and ranged from 16% (caudate) to 42% (cerebellar gray matter) for all global and most subcortical volumes (with the exception of thalamus and pallidum). Heritability estimates of change rates were generally higher in adults than in children suggesting an increasing influence of genetic factors explaining individual differences in brain structural changes with age. In children, environmental influences in part explained individual differences in developmental changes in brain structure. Multivariate genetic modeling showed that genetic influences of change rates and baseline volume significantly overlapped for many structures. The genetic influences explaining individual differences in the change rate for cerebellum, cerebellar gray matter and lateral ventricles were independent of the genetic influences explaining differences in their baseline volumes. These results imply the existence of genetic variants that are specific for brain plasticity, rather than brain volume itself. Identifying these genes may increase our understanding of brain development and ageing and possibly have implications for diseases that are characterized by deviant developmental trajectories of brain structure. Hum Brain Mapp, 2017. {\textcopyright} 2017 Wiley Periodicals, Inc.",

keywords = "Journal Article",

author = "Brouwer, {Rachel M} and Panizzon, {Matthew S} and Glahn, {David C} and Hibar, {Derrek P} and Xue Hua and Neda Jahanshad and Lucija Abramovic and {De Zubicaray}, {Greig I} and Franz, {Carol E} and Hansell, {Narelle K} and Hickie, {Ian B} and Koenis, {Marinka M G} and Martin, {Nicholas G} and Mather, {Karen A} and McMahon, {Katie L} and Schnack, {Hugo G} and Strike, {Lachlan T} and Swagerman, {Suzanne C} and Anbupalam Thalamuthu and Wei Wen and Gilmore, {John H} and Nitin Gogtay and Kahn, {Ren{\'e} S} and Sachdev, {Perminder S} and Wright, {Margaret J} and Boomsma, {Dorret I} and Kremen, {William S} and Thompson, {Paul M} and {Hulshoff Pol}, {Hilleke E}",

note = "{\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2017",

month = sep,

doi = "10.1002/hbm.23672",

language = "English",

volume = "38",

pages = "4444--4458",

journal = "Human Brain Mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

number = "9",

}

Brouwer, RM, Panizzon, MS, Glahn, DC, Hibar, DP, Hua, X, Jahanshad, N, Abramovic, L, De Zubicaray, GI, Franz, CE, Hansell, NK, Hickie, IB, Koenis, MMG, Martin, NG, Mather, KA, McMahon, KL, Schnack, HG, Strike, LT, Swagerman, SC, Thalamuthu, A, Wen, W, Gilmore, JH, Gogtay, N, Kahn, RS, Sachdev, PS, Wright, MJ, Boomsma, DI, Kremen, WS, Thompson, PM & Hulshoff Pol, HE 2017, 'Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group', Human Brain Mapping, vol. 38, no. 9, pp. 4444-4458. https://doi.org/10.1002/hbm.23672

TY - JOUR

T1 - Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes

T2 - Results of the ENIGMA plasticity working group

AU - Brouwer, Rachel M

AU - Panizzon, Matthew S

AU - Glahn, David C

AU - Hibar, Derrek P

AU - Hua, Xue

AU - Jahanshad, Neda

AU - Abramovic, Lucija

AU - De Zubicaray, Greig I

AU - Franz, Carol E

AU - Hansell, Narelle K

AU - Hickie, Ian B

AU - Koenis, Marinka M G

AU - Martin, Nicholas G

AU - Mather, Karen A

AU - McMahon, Katie L

AU - Schnack, Hugo G

AU - Strike, Lachlan T

AU - Swagerman, Suzanne C

AU - Thalamuthu, Anbupalam

AU - Wen, Wei

AU - Gilmore, John H

AU - Gogtay, Nitin

AU - Kahn, René S

AU - Sachdev, Perminder S

AU - Wright, Margaret J

AU - Boomsma, Dorret I

AU - Kremen, William S

AU - Thompson, Paul M

AU - Hulshoff Pol, Hilleke E

PY - 2017/9

Y1 - 2017/9

N2 - Structural brain changes that occur during development and ageing are related to mental health and general cognitive functioning. Individuals differ in the extent to which their brain volumes change over time, but whether these differences can be attributed to differences in their genotypes has not been widely studied. Here we estimate heritability (h(2) ) of changes in global and subcortical brain volumes in five longitudinal twin cohorts from across the world and in different stages of the lifespan (N = 861). Heritability estimates of brain changes were significant and ranged from 16% (caudate) to 42% (cerebellar gray matter) for all global and most subcortical volumes (with the exception of thalamus and pallidum). Heritability estimates of change rates were generally higher in adults than in children suggesting an increasing influence of genetic factors explaining individual differences in brain structural changes with age. In children, environmental influences in part explained individual differences in developmental changes in brain structure. Multivariate genetic modeling showed that genetic influences of change rates and baseline volume significantly overlapped for many structures. The genetic influences explaining individual differences in the change rate for cerebellum, cerebellar gray matter and lateral ventricles were independent of the genetic influences explaining differences in their baseline volumes. These results imply the existence of genetic variants that are specific for brain plasticity, rather than brain volume itself. Identifying these genes may increase our understanding of brain development and ageing and possibly have implications for diseases that are characterized by deviant developmental trajectories of brain structure. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc.

AB - Structural brain changes that occur during development and ageing are related to mental health and general cognitive functioning. Individuals differ in the extent to which their brain volumes change over time, but whether these differences can be attributed to differences in their genotypes has not been widely studied. Here we estimate heritability (h(2) ) of changes in global and subcortical brain volumes in five longitudinal twin cohorts from across the world and in different stages of the lifespan (N = 861). Heritability estimates of brain changes were significant and ranged from 16% (caudate) to 42% (cerebellar gray matter) for all global and most subcortical volumes (with the exception of thalamus and pallidum). Heritability estimates of change rates were generally higher in adults than in children suggesting an increasing influence of genetic factors explaining individual differences in brain structural changes with age. In children, environmental influences in part explained individual differences in developmental changes in brain structure. Multivariate genetic modeling showed that genetic influences of change rates and baseline volume significantly overlapped for many structures. The genetic influences explaining individual differences in the change rate for cerebellum, cerebellar gray matter and lateral ventricles were independent of the genetic influences explaining differences in their baseline volumes. These results imply the existence of genetic variants that are specific for brain plasticity, rather than brain volume itself. Identifying these genes may increase our understanding of brain development and ageing and possibly have implications for diseases that are characterized by deviant developmental trajectories of brain structure. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85020183556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020183556&partnerID=8YFLogxK

U2 - 10.1002/hbm.23672

DO - 10.1002/hbm.23672

M3 - Article

C2 - 28580697

SN - 1065-9471

VL - 38

SP - 4444

EP - 4458

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 9

ER -

Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group

Abstract

Funding

Keywords

Cohort Studies

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this