TY - JOUR
T1 - Genetic Moderation of Intervention Efficacy
T2 - Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children
AU - Chhangur, Rabia R.
AU - Weeland, Joyce
AU - Overbeek, Geertjan
AU - Matthys, Walter
AU - Orobio de Castro, Bram
AU - van der Giessen, Danielle
AU - Belsky, Jay
PY - 2017/5/1
Y1 - 2017/5/1
N2 - This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents’ manifested the most positive change in parenting in response to the intervention. These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity).
AB - This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents’ manifested the most positive change in parenting in response to the intervention. These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity).
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U2 - 10.1111/cdev.12612
DO - 10.1111/cdev.12612
M3 - Article
C2 - 27629597
AN - SCOPUS:84994030679
SN - 0009-3920
VL - 88
SP - 796
EP - 811
JO - Child Development
JF - Child Development
IS - 3
ER -