Genetic schizophrenia risk variants jointly modulate total brain and white matter volume

A.F. Terwisscha van Scheltinga; S.C. Bakker; N.E. Haren; E.M. Derks; J.E. Buizer-Voskamp; H.B. Boos; W. Cahn; H.E. Hulshoff Pol; S. Ripke; R. A. Ophoff; D. Posthuma; R. S. Kahn

doi:10.1016/j.biopsych.2012.08.017

Genetic schizophrenia risk variants jointly modulate total brain and white matter volume

A.F. Terwisscha van Scheltinga, S.C. Bakker, N.E. Haren, E.M. Derks, J.E. Buizer-Voskamp, H.B. Boos, W. Cahn, H.E. Hulshoff Pol, S. Ripke, R. A. Ophoff, D. Posthuma, R. S. Kahn

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Thousands of common single nucleotide polymorphisms (SNPs) are weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume. Methods: Odds ratios for genome-wide SNP data were calculated in the sample collected by the Psychiatric Genome-wide Association Study Consortium (8690 schizophrenia patients and 11,831 control subjects, excluding subjects from the present study). These were used to calculate individual polygenic schizophrenia (risk) scores in an independent sample of 152 schizophrenia patients and 142 healthy control subjects with available structural magnetic resonance imaging scans. Results: In the entire group, the polygenic schizophrenia score was significantly associated with total brain volume (R

Original language	English
Pages (from-to)	525-531
Journal	Biological Psychiatry
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/j.biopsych.2012.08.017
Publication status	Published - 2013

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Psychiatric Genome-wide Association Study Consortium

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Terwisscha van Scheltinga, A. F., Bakker, S. C., Haren, N. E., Derks, E. M., Buizer-Voskamp, J. E., Boos, H. B., Cahn, W., Hulshoff Pol, H. E., Ripke, S., Ophoff, R. A., Posthuma, D., & Kahn, R. S. (2013). Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry, 73(6), 525-531. https://doi.org/10.1016/j.biopsych.2012.08.017

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abstract = "Background: Thousands of common single nucleotide polymorphisms (SNPs) are weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume. Methods: Odds ratios for genome-wide SNP data were calculated in the sample collected by the Psychiatric Genome-wide Association Study Consortium (8690 schizophrenia patients and 11,831 control subjects, excluding subjects from the present study). These were used to calculate individual polygenic schizophrenia (risk) scores in an independent sample of 152 schizophrenia patients and 142 healthy control subjects with available structural magnetic resonance imaging scans. Results: In the entire group, the polygenic schizophrenia score was significantly associated with total brain volume (R",

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AU - Terwisscha van Scheltinga, A.F.

AU - Bakker, S.C.

AU - Haren, N.E.

AU - Derks, E.M.

AU - Buizer-Voskamp, J.E.

AU - Boos, H.B.

AU - Cahn, W.

AU - Hulshoff Pol, H.E.

AU - Ripke, S.

AU - Ophoff, R. A.

AU - Posthuma, D.

AU - Kahn, R. S.

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AB - Background: Thousands of common single nucleotide polymorphisms (SNPs) are weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume. Methods: Odds ratios for genome-wide SNP data were calculated in the sample collected by the Psychiatric Genome-wide Association Study Consortium (8690 schizophrenia patients and 11,831 control subjects, excluding subjects from the present study). These were used to calculate individual polygenic schizophrenia (risk) scores in an independent sample of 152 schizophrenia patients and 142 healthy control subjects with available structural magnetic resonance imaging scans. Results: In the entire group, the polygenic schizophrenia score was significantly associated with total brain volume (R

U2 - 10.1016/j.biopsych.2012.08.017

DO - 10.1016/j.biopsych.2012.08.017

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JF - Biological Psychiatry

SN - 0006-3223

IS - 6

ER -

Genetic schizophrenia risk variants jointly modulate total brain and white matter volume

Abstract

Bibliographical note

UN SDGs

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