Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

A. Okbay, B.M.L. Baselmans, J.E. de Neve, P. Turley, M.G. Nivard, M.A. Fontana, S.F.W. Meddens, R. Karlsson Linnér, C.A. Rietveld, J. Derringer, R. de Vlaming, C.C. Minica, J.J. Hottenga, A.A.E. Vinkhuyzen, D.I. Boomsma, E.J.C. de Geus, S.E. Medland, M.N. Meyer, J.K. Pickrell, T. Esko & 6 others R.F. Krueger, J. Beauchamp, P.D. Koellinger, D.J. Benjamin, M. Bartels, D. Cesarini

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Original languageEnglish
Pages (from-to)624-633
JournalNature Genetics
Volume48
Issue number6
DOIs
Publication statusPublished - 2016

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Genome
Depression
Phenotype
Genome-Wide Association Study
Sample Size
Pancreas
Central Nervous System
Joints
Neuroticism

Cite this

Okbay, A. ; Baselmans, B.M.L. ; de Neve, J.E. ; Turley, P. ; Nivard, M.G. ; Fontana, M.A. ; Meddens, S.F.W. ; Karlsson Linnér, R. ; Rietveld, C.A. ; Derringer, J. ; de Vlaming, R. ; Minica, C.C. ; Hottenga, J.J. ; Vinkhuyzen, A.A.E. ; Boomsma, D.I. ; de Geus, E.J.C. ; Medland, S.E. ; Meyer, M.N. ; Pickrell, J.K. ; Esko, T. ; Krueger, R.F. ; Beauchamp, J. ; Koellinger, P.D. ; Benjamin, D.J. ; Bartels, M. ; Cesarini, D. / Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. In: Nature Genetics. 2016 ; Vol. 48, No. 6. pp. 624-633.
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abstract = "Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.",
author = "A. Okbay and B.M.L. Baselmans and {de Neve}, J.E. and P. Turley and M.G. Nivard and M.A. Fontana and S.F.W. Meddens and {Karlsson Linn{\'e}r}, R. and C.A. Rietveld and J. Derringer and {de Vlaming}, R. and C.C. Minica and J.J. Hottenga and A.A.E. Vinkhuyzen and D.I. Boomsma and {de Geus}, E.J.C. and S.E. Medland and M.N. Meyer and J.K. Pickrell and T. Esko and R.F. Krueger and J. Beauchamp and P.D. Koellinger and D.J. Benjamin and M. Bartels and D. Cesarini",
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Okbay, A, Baselmans, BML, de Neve, JE, Turley, P, Nivard, MG, Fontana, MA, Meddens, SFW, Karlsson Linnér, R, Rietveld, CA, Derringer, J, de Vlaming, R, Minica, CC, Hottenga, JJ, Vinkhuyzen, AAE, Boomsma, DI, de Geus, EJC, Medland, SE, Meyer, MN, Pickrell, JK, Esko, T, Krueger, RF, Beauchamp, J, Koellinger, PD, Benjamin, DJ, Bartels, M & Cesarini, D 2016, 'Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.' Nature Genetics, vol. 48, no. 6, pp. 624-633. https://doi.org/10.1038/ng.3552

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. / Okbay, A.; Baselmans, B.M.L.; de Neve, J.E.; Turley, P.; Nivard, M.G.; Fontana, M.A.; Meddens, S.F.W.; Karlsson Linnér, R.; Rietveld, C.A.; Derringer, J.; de Vlaming, R.; Minica, C.C.; Hottenga, J.J.; Vinkhuyzen, A.A.E.; Boomsma, D.I.; de Geus, E.J.C.; Medland, S.E.; Meyer, M.N.; Pickrell, J.K.; Esko, T.; Krueger, R.F.; Beauchamp, J.; Koellinger, P.D.; Benjamin, D.J.; Bartels, M.; Cesarini, D.

In: Nature Genetics, Vol. 48, No. 6, 2016, p. 624-633.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Okbay, A.

AU - Baselmans, B.M.L.

AU - de Neve, J.E.

AU - Turley, P.

AU - Nivard, M.G.

AU - Fontana, M.A.

AU - Meddens, S.F.W.

AU - Karlsson Linnér, R.

AU - Rietveld, C.A.

AU - Derringer, J.

AU - de Vlaming, R.

AU - Minica, C.C.

AU - Hottenga, J.J.

AU - Vinkhuyzen, A.A.E.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

AU - Medland, S.E.

AU - Meyer, M.N.

AU - Pickrell, J.K.

AU - Esko, T.

AU - Krueger, R.F.

AU - Beauchamp, J.

AU - Koellinger, P.D.

AU - Benjamin, D.J.

AU - Bartels, M.

AU - Cesarini, D.

PY - 2016

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N2 - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

AB - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

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DO - 10.1038/ng.3552

M3 - Article

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EP - 633

JO - Nature Genetics

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