Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

A. Okbay; B.M.L. Baselmans; J.E. de Neve; P. Turley; M.G. Nivard; M.A. Fontana; S.F.W. Meddens; R. Karlsson Linnér; C.A. Rietveld; J. Derringer; R. de Vlaming; C.C. Minica; J.J. Hottenga; A.A.E. Vinkhuyzen; D.I. Boomsma; E.J.C. de Geus; S.E. Medland; M.N. Meyer; J.K. Pickrell; T. Esko; R.F. Krueger; J. Beauchamp; P.D. Koellinger; D.J. Benjamin; M. Bartels; D. Cesarini

doi:10.1038/ng.3552

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

A. Okbay, B.M.L. Baselmans, J.E. de Neve, P. Turley, M.G. Nivard, M.A. Fontana, S.F.W. Meddens, R. Karlsson Linnér, C.A. Rietveld, J. Derringer, R. de Vlaming, C.C. Minica, J.J. Hottenga, A.A.E. Vinkhuyzen, D.I. Boomsma, E.J.C. de Geus, S.E. Medland, M.N. Meyer, J.K. Pickrell, T. EskoR.F. Krueger, J. Beauchamp, P.D. Koellinger, D.J. Benjamin, M. Bartels, D. Cesarini

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Original language	English
Pages (from-to)	624-633
Journal	Nature Genetics
Volume	48
Issue number	6
DOIs	https://doi.org/10.1038/ng.3552
Publication status	Published - 2016

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Okbay, A., Baselmans, B. M. L., de Neve, J. E., Turley, P., Nivard, M. G., Fontana, M. A., Meddens, S. F. W., Karlsson Linnér, R., Rietveld, C. A., Derringer, J., de Vlaming, R., Minica, C. C., Hottenga, J. J., Vinkhuyzen, A. A. E., Boomsma, D. I., de Geus, E. J. C., Medland, S. E., Meyer, M. N., Pickrell, J. K., ... Cesarini, D. (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48(6), 624-633. https://doi.org/10.1038/ng.3552

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title = "Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.",

abstract = "Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.",

author = "A. Okbay and B.M.L. Baselmans and {de Neve}, J.E. and P. Turley and M.G. Nivard and M.A. Fontana and S.F.W. Meddens and {Karlsson Linn{\'e}r}, R. and C.A. Rietveld and J. Derringer and {de Vlaming}, R. and C.C. Minica and J.J. Hottenga and A.A.E. Vinkhuyzen and D.I. Boomsma and {de Geus}, E.J.C. and S.E. Medland and M.N. Meyer and J.K. Pickrell and T. Esko and R.F. Krueger and J. Beauchamp and P.D. Koellinger and D.J. Benjamin and M. Bartels and D. Cesarini",

year = "2016",

doi = "10.1038/ng.3552",

language = "English",

volume = "48",

pages = "624--633",

journal = "Nature Genetics",

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Okbay, A, Baselmans, BML, de Neve, JE, Turley, P, Nivard, MG, Fontana, MA, Meddens, SFW, Karlsson Linnér, R, Rietveld, CA, Derringer, J, de Vlaming, R, Minica, CC, Hottenga, JJ, Vinkhuyzen, AAE, Boomsma, DI , de Geus, EJC, Medland, SE, Meyer, MN, Pickrell, JK, Esko, T, Krueger, RF, Beauchamp, J, Koellinger, PD, Benjamin, DJ, Bartels, M & Cesarini, D 2016, 'Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.', Nature Genetics, vol. 48, no. 6, pp. 624-633. https://doi.org/10.1038/ng.3552

TY - JOUR

T1 - Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

AU - Okbay, A.

AU - Baselmans, B.M.L.

AU - de Neve, J.E.

AU - Turley, P.

AU - Nivard, M.G.

AU - Fontana, M.A.

AU - Meddens, S.F.W.

AU - Karlsson Linnér, R.

AU - Rietveld, C.A.

AU - Derringer, J.

AU - de Vlaming, R.

AU - Minica, C.C.

AU - Hottenga, J.J.

AU - Vinkhuyzen, A.A.E.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

AU - Medland, S.E.

AU - Meyer, M.N.

AU - Pickrell, J.K.

AU - Esko, T.

AU - Krueger, R.F.

AU - Beauchamp, J.

AU - Koellinger, P.D.

AU - Benjamin, D.J.

AU - Bartels, M.

AU - Cesarini, D.

PY - 2016

Y1 - 2016

N2 - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

AB - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

U2 - 10.1038/ng.3552

DO - 10.1038/ng.3552

M3 - Article

SN - 1061-4036

VL - 48

SP - 624

EP - 633

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Abstract

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