Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence

Marieke Hiemstra, Stefanie A. Nelemans, Susan Branje, Kristel R. van Eijk, Jouke Jan Hottenga, Christiaan H. Vinkers, Pol van Lier, Wim Meeus, Marco P. Boks

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years). Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001. Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found. Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.

Original languageEnglish
Pages (from-to)143-150
Number of pages8
JournalDrug and Alcohol Dependence
Volume190
Early online date30 Jun 2018
DOIs
Publication statusPublished - 1 Sep 2018

Fingerprint

Cannabis
Schizophrenia
Alcohols
Smoking
Marijuana Smoking
Genetic Predisposition to Disease
Testing
Longitudinal Studies
Comorbidity
Growth

Keywords

  • Adolescence
  • Alcohol use
  • Cannabis use
  • Genetic
  • Polygenic risk score
  • Schizophrenia
  • Smoking
  • Substance use

Cite this

Hiemstra, Marieke ; Nelemans, Stefanie A. ; Branje, Susan ; van Eijk, Kristel R. ; Hottenga, Jouke Jan ; Vinkers, Christiaan H. ; van Lier, Pol ; Meeus, Wim ; Boks, Marco P. / Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence. In: Drug and Alcohol Dependence. 2018 ; Vol. 190. pp. 143-150.
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abstract = "Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years). Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001. Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found. Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.",
keywords = "Adolescence, Alcohol use, Cannabis use, Genetic, Polygenic risk score, Schizophrenia, Smoking, Substance use",
author = "Marieke Hiemstra and Nelemans, {Stefanie A.} and Susan Branje and {van Eijk}, {Kristel R.} and Hottenga, {Jouke Jan} and Vinkers, {Christiaan H.} and {van Lier}, Pol and Wim Meeus and Boks, {Marco P.}",
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Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence. / Hiemstra, Marieke; Nelemans, Stefanie A.; Branje, Susan; van Eijk, Kristel R.; Hottenga, Jouke Jan; Vinkers, Christiaan H.; van Lier, Pol; Meeus, Wim; Boks, Marco P.

In: Drug and Alcohol Dependence, Vol. 190, 01.09.2018, p. 143-150.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence

AU - Hiemstra, Marieke

AU - Nelemans, Stefanie A.

AU - Branje, Susan

AU - van Eijk, Kristel R.

AU - Hottenga, Jouke Jan

AU - Vinkers, Christiaan H.

AU - van Lier, Pol

AU - Meeus, Wim

AU - Boks, Marco P.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years). Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001. Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found. Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.

AB - Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years). Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001. Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found. Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.

KW - Adolescence

KW - Alcohol use

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KW - Genetic

KW - Polygenic risk score

KW - Schizophrenia

KW - Smoking

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DO - 10.1016/j.drugalcdep.2018.05.024

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