TY - JOUR
T1 - Genetically-Informed Patient Selection for iPSC Studies of Complex Diseases May Aid in Reducing Cellular Heterogeneity
AU - Hoekstra, Stephanie D
AU - Stringer, Sven
AU - Heine, Vivi M
AU - Posthuma, Danielle
PY - 2017
Y1 - 2017
N2 - Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.
AB - Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.
KW - Journal Article
UR - http://www.scopus.com/inward/record.url?scp=85021682256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021682256&partnerID=8YFLogxK
U2 - 10.3389/fncel.2017.00164
DO - 10.3389/fncel.2017.00164
M3 - Article
C2 - 28659762
SN - 1662-5102
VL - 11
SP - 164
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
M1 - 164
ER -