Genetics of obsessive-compulsive disorder and Tourette's syndrome

N. Rodrigues Zilhao Nogueira, Dorret Boomsma, D.J.A. Smit, Danielle C Cath

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Abstract

Obsessive–compulsive disorder (OCD) and Tourette Syndrome (TS) are two common psychiatric disorders affecting approximately 1–3% of the population. Over the years, considerable progress has been made in conceptualizing these disorders, both clinically and genetically, from simple manifestations of psychological disturbances to highly polygenic, heritable disorders. Family and twin studies have shown that both disorders are familial, and partly influenced by genetic factors. Heritability estimates range between 0.26 and 0.60 for OCD, and 0.25 and 0.54 for TS, but despite this steady progress, results remain inconclusive regarding specific etiological genetic causes. Currently, a remarkable increase in international collaborative efforts within psychiatric genetics has opened new research possibilities, with larger datasets and multiple sources of genetic information available. This chapter provides a broad and updated overview of the genetics of OCD and TS and their genetic association. Historical evidence from past literature and recent results in light of current research are summarized.
Original languageEnglish
Title of host publicationGenes, Brain and Emotions
Subtitle of host publicationInterdisciplinary and Translational Perspectives
EditorsA.C. Miu, J.R. Romberg, K.P. Lesch
PublisherOxford University Press
Pages380–395
Number of pages16
ISBN (Electronic)9780192511423, 9780191834745
ISBN (Print)9780198793014
DOIs
Publication statusPublished - 2019

Publication series

NameSeries in Affective Science
PublisherOxford University Press

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