TY - CHAP
T1 - Genetics of obsessive-compulsive disorder and Tourette's syndrome
AU - Rodrigues Zilhao Nogueira, N.
AU - Boomsma, Dorret
AU - Smit, D.J.A.
AU - Cath, Danielle C
PY - 2019
Y1 - 2019
N2 - Obsessive–compulsive disorder (OCD) and Tourette Syndrome (TS) are two common psychiatric disorders affecting approximately 1–3% of the population. Over the years, considerable progress has been made in conceptualizing these disorders, both clinically and genetically, from simple manifestations of psychological disturbances to highly polygenic, heritable disorders. Family and twin studies have shown that both disorders are familial, and partly influenced by genetic factors. Heritability estimates range between 0.26 and 0.60 for OCD, and 0.25 and 0.54 for TS, but despite this steady progress, results remain inconclusive regarding specific etiological genetic causes. Currently, a remarkable increase in international collaborative efforts within psychiatric genetics has opened new research possibilities, with larger datasets and multiple sources of genetic information available. This chapter provides a broad and updated overview of the genetics of OCD and TS and their genetic association. Historical evidence from past literature and recent results in light of current research are summarized.
AB - Obsessive–compulsive disorder (OCD) and Tourette Syndrome (TS) are two common psychiatric disorders affecting approximately 1–3% of the population. Over the years, considerable progress has been made in conceptualizing these disorders, both clinically and genetically, from simple manifestations of psychological disturbances to highly polygenic, heritable disorders. Family and twin studies have shown that both disorders are familial, and partly influenced by genetic factors. Heritability estimates range between 0.26 and 0.60 for OCD, and 0.25 and 0.54 for TS, but despite this steady progress, results remain inconclusive regarding specific etiological genetic causes. Currently, a remarkable increase in international collaborative efforts within psychiatric genetics has opened new research possibilities, with larger datasets and multiple sources of genetic information available. This chapter provides a broad and updated overview of the genetics of OCD and TS and their genetic association. Historical evidence from past literature and recent results in light of current research are summarized.
UR - https://global.oup.com/academic/product/genes-brain-and-emotions-9780198793014
U2 - 10.1093/oso/9780198793014.003.0025
DO - 10.1093/oso/9780198793014.003.0025
M3 - Chapter
SN - 9780198793014
T3 - Series in Affective Science
SP - 380
EP - 395
BT - Genes, Brain and Emotions
A2 - Miu, A.C.
A2 - Romberg, J.R.
A2 - Lesch, K.P.
PB - Oxford University Press
ER -