Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

E.M. van Leeuwen, L.C. Karssen, J. Deelen, A. Isaacs, C. Medina-Gomez, H. Mbarek, A. Kanterakis, S. Trompet, I. Postmus, N. Verweij, D. van Enckevort, J.E. Huffman, C.C. White, M.F. Feitosa, T.M. Bartz, A. Manichaikul, P.K. Joshi, G.M. Peloso, P. Deelen, F. DijkG. Willemsen, E.J.C. de Geus, Y. Milaneschi, B.W.J.H. Penninx, L.C. Francioli, A. Menelaou, S.L. Pulit, F. Rivadeneira, A. Hofman, B.A. Oostra, O.H. Franco, I. Mateo Leach, M. Beekman, A.J. de Craen, H.W. Uh, H. Trochet, L.J. Hocking, D.J. Porteous, N. Sattar, C.J. Packard, B.M. Buckley, J.A. Brody, J.C. Bis, J.I. Rotter, J.C. Mychaleckyj, H. Campbell, Q. Duan, L.A. Lange, J.F. Wilson, C. Hayward, O. Polasek, V. Vitart, I. Rudan, A.F. Wright, S.S. Rich, B.M. Psaty, I.B. Borecki, P.M. Kearney, D.J. Stott, L.A. Cupples, J.W. Jukema, P. van der Harst, E.J. Sijbrands, J.J. Hottenga, A.G. Uitterlinden, M.A. Swertz, G.J.B van Ommen, P.I.W. Bakker, P.E. Slagboom, D.I. Boomsma, C. Wijmenga, C.M. van Duijn

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (∼35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value <6.61 × 10
Original languageEnglish
Article number6065
Pages (from-to)6065
Number of pages6
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 2015

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