Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

E.M. van Leeuwen; L.C. Karssen; J. Deelen; A. Isaacs; C. Medina-Gomez; H. Mbarek; A. Kanterakis; S. Trompet; I. Postmus; N. Verweij; D. van Enckevort; J.E. Huffman; C.C. White; M.F. Feitosa; T.M. Bartz; A. Manichaikul; P.K. Joshi; G.M. Peloso; P. Deelen; F. Dijk; G. Willemsen; E.J.C. de Geus; Y. Milaneschi; B.W.J.H. Penninx; L.C. Francioli; A. Menelaou; S.L. Pulit; F. Rivadeneira; A. Hofman; B.A. Oostra; O.H. Franco; I. Mateo Leach; M. Beekman; A.J. de Craen; H.W. Uh; H. Trochet; L.J. Hocking; D.J. Porteous; N. Sattar; C.J. Packard; B.M. Buckley; J.A. Brody; J.C. Bis; J.I. Rotter; J.C. Mychaleckyj; H. Campbell; Q. Duan; L.A. Lange; J.F. Wilson; C. Hayward; O. Polasek; V. Vitart; I. Rudan; A.F. Wright; S.S. Rich; B.M. Psaty; I.B. Borecki; P.M. Kearney; D.J. Stott; L.A. Cupples; J.W. Jukema; P. van der Harst; E.J. Sijbrands; J.J. Hottenga; A.G. Uitterlinden; M.A. Swertz; G.J.B van Ommen; P.I.W. Bakker; P.E. Slagboom; D.I. Boomsma; C. Wijmenga; C.M. van Duijn

doi:10.1038/ncomms7065

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

E.M. van Leeuwen, L.C. Karssen, J. Deelen, A. Isaacs, C. Medina-Gomez, H. Mbarek, A. Kanterakis, S. Trompet, I. Postmus, N. Verweij, D. van Enckevort, J.E. Huffman, C.C. White, M.F. Feitosa, T.M. Bartz, A. Manichaikul, P.K. Joshi, G.M. Peloso, P. Deelen, F. DijkG. Willemsen, E.J.C. de Geus, Y. Milaneschi, B.W.J.H. Penninx, L.C. Francioli, A. Menelaou, S.L. Pulit, F. Rivadeneira, A. Hofman, B.A. Oostra, O.H. Franco, I. Mateo Leach, M. Beekman, A.J. de Craen, H.W. Uh, H. Trochet, L.J. Hocking, D.J. Porteous, N. Sattar, C.J. Packard, B.M. Buckley, J.A. Brody, J.C. Bis, J.I. Rotter, J.C. Mychaleckyj, H. Campbell, Q. Duan, L.A. Lange, J.F. Wilson, C. Hayward, O. Polasek, V. Vitart, I. Rudan, A.F. Wright, S.S. Rich, B.M. Psaty, I.B. Borecki, P.M. Kearney, D.J. Stott, L.A. Cupples, J.W. Jukema, P. van der Harst, E.J. Sijbrands, J.J. Hottenga, A.G. Uitterlinden, M.A. Swertz, G.J.B van Ommen, P.I.W. Bakker, P.E. Slagboom, D.I. Boomsma, C. Wijmenga, C.M. van Duijn

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (∼35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value <6.61 × 10

Original language	English
Article number	6065
Pages (from-to)	6065
Number of pages	6
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms7065
Publication status	Published - 2015

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., ... van Duijn, C. M. (2015). Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels. Nature Communications, 6, 6065. Article 6065. https://doi.org/10.1038/ncomms7065

@article{228a7a1ac9a94d32b462ad04b4d04c48,

title = "Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels",

abstract = "Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (∼35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value <6.61 × 10",

author = "{van Leeuwen}, E.M. and L.C. Karssen and J. Deelen and A. Isaacs and C. Medina-Gomez and H. Mbarek and A. Kanterakis and S. Trompet and I. Postmus and N. Verweij and {van Enckevort}, D. and J.E. Huffman and C.C. White and M.F. Feitosa and T.M. Bartz and A. Manichaikul and P.K. Joshi and G.M. Peloso and P. Deelen and F. Dijk and G. Willemsen and {de Geus}, E.J.C. and Y. Milaneschi and B.W.J.H. Penninx and L.C. Francioli and A. Menelaou and S.L. Pulit and F. Rivadeneira and A. Hofman and B.A. Oostra and O.H. Franco and {Mateo Leach}, I. and M. Beekman and {de Craen}, A.J. and H.W. Uh and H. Trochet and L.J. Hocking and D.J. Porteous and N. Sattar and C.J. Packard and B.M. Buckley and J.A. Brody and J.C. Bis and J.I. Rotter and J.C. Mychaleckyj and H. Campbell and Q. Duan and L.A. Lange and J.F. Wilson and C. Hayward and O. Polasek and V. Vitart and I. Rudan and A.F. Wright and S.S. Rich and B.M. Psaty and I.B. Borecki and P.M. Kearney and D.J. Stott and L.A. Cupples and J.W. Jukema and {van der Harst}, P. and E.J. Sijbrands and J.J. Hottenga and A.G. Uitterlinden and M.A. Swertz and {van Ommen}, G.J.B and P.I.W. Bakker and P.E. Slagboom and D.I. Boomsma and C. Wijmenga and {van Duijn}, C.M.",

year = "2015",

doi = "10.1038/ncomms7065",

language = "English",

volume = "6",

pages = "6065",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

van Leeuwen, EM, Karssen, LC, Deelen, J, Isaacs, A, Medina-Gomez, C, Mbarek, H, Kanterakis, A, Trompet, S, Postmus, I, Verweij, N, van Enckevort, D, Huffman, JE, White, CC, Feitosa, MF, Bartz, TM, Manichaikul, A, Joshi, PK, Peloso, GM, Deelen, P, Dijk, F, Willemsen, G, de Geus, EJC, Milaneschi, Y, Penninx, BWJH, Francioli, LC, Menelaou, A, Pulit, SL, Rivadeneira, F, Hofman, A, Oostra, BA, Franco, OH, Mateo Leach, I, Beekman, M, de Craen, AJ, Uh, HW, Trochet, H, Hocking, LJ, Porteous, DJ, Sattar, N, Packard, CJ, Buckley, BM, Brody, JA, Bis, JC, Rotter, JI, Mychaleckyj, JC, Campbell, H, Duan, Q, Lange, LA, Wilson, JF, Hayward, C, Polasek, O, Vitart, V, Rudan, I, Wright, AF, Rich, SS, Psaty, BM, Borecki, IB, Kearney, PM, Stott, DJ, Cupples, LA, Jukema, JW, van der Harst, P, Sijbrands, EJ, Hottenga, JJ, Uitterlinden, AG, Swertz, MA, van Ommen, GJB, Bakker, PIW, Slagboom, PE, Boomsma, DI, Wijmenga, C & van Duijn, CM 2015, 'Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels', Nature Communications, vol. 6, 6065, pp. 6065. https://doi.org/10.1038/ncomms7065

TY - JOUR

T1 - Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

AU - van Leeuwen, E.M.

AU - Karssen, L.C.

AU - Deelen, J.

AU - Isaacs, A.

AU - Medina-Gomez, C.

AU - Mbarek, H.

AU - Kanterakis, A.

AU - Trompet, S.

AU - Postmus, I.

AU - Verweij, N.

AU - van Enckevort, D.

AU - Huffman, J.E.

AU - White, C.C.

AU - Feitosa, M.F.

AU - Bartz, T.M.

AU - Manichaikul, A.

AU - Joshi, P.K.

AU - Peloso, G.M.

AU - Deelen, P.

AU - Dijk, F.

AU - Willemsen, G.

AU - de Geus, E.J.C.

AU - Milaneschi, Y.

AU - Penninx, B.W.J.H.

AU - Francioli, L.C.

AU - Menelaou, A.

AU - Pulit, S.L.

AU - Rivadeneira, F.

AU - Hofman, A.

AU - Oostra, B.A.

AU - Franco, O.H.

AU - Mateo Leach, I.

AU - Beekman, M.

AU - de Craen, A.J.

AU - Uh, H.W.

AU - Trochet, H.

AU - Hocking, L.J.

AU - Porteous, D.J.

AU - Sattar, N.

AU - Packard, C.J.

AU - Buckley, B.M.

AU - Brody, J.A.

AU - Bis, J.C.

AU - Rotter, J.I.

AU - Mychaleckyj, J.C.

AU - Campbell, H.

AU - Duan, Q.

AU - Lange, L.A.

AU - Wilson, J.F.

AU - Hayward, C.

AU - Polasek, O.

AU - Vitart, V.

AU - Rudan, I.

AU - Wright, A.F.

AU - Rich, S.S.

AU - Psaty, B.M.

AU - Borecki, I.B.

AU - Kearney, P.M.

AU - Stott, D.J.

AU - Cupples, L.A.

AU - Jukema, J.W.

AU - van der Harst, P.

AU - Sijbrands, E.J.

AU - Hottenga, J.J.

AU - Uitterlinden, A.G.

AU - Swertz, M.A.

AU - van Ommen, G.J.B

AU - Bakker, P.I.W.

AU - Slagboom, P.E.

AU - Boomsma, D.I.

AU - Wijmenga, C.

AU - van Duijn, C.M.

PY - 2015

Y1 - 2015

N2 - Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (∼35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value <6.61 × 10

AB - Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (∼35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value <6.61 × 10

U2 - 10.1038/ncomms7065

DO - 10.1038/ncomms7065

M3 - Article

SN - 2041-1723

VL - 6

SP - 6065

JO - Nature Communications

JF - Nature Communications

M1 - 6065

ER -

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

Abstract

Cohort Studies

UN SDGs

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