Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

N. Barban; R. Jansen; Ronald de Vlaming; A. Vaez; J.J. Mandemakers; F.C. Tropf; X. Shen; J.F. Wilson; D.I. Chasman; I.M. Nolte; H. Mbarek; D.I. Boomsma; E.J.C. de Geus; B.W.J.H. Penninx; G. Willemsen; K.T. Zondervan; K. Stefansson; R.F. Krueger; J.J. Lee; D.J. Benjamin; D. Cesarini; P.D. Koellinger; M.A.H. den Hoed; H. Snieder; M.C. Mills

doi:10.1038/ng.3698

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

N. Barban, R. Jansen, Ronald de Vlaming, A. Vaez, J.J. Mandemakers, F.C. Tropf, X. Shen, J.F. Wilson, D.I. Chasman, I.M. Nolte, H. Mbarek, D.I. Boomsma, E.J.C. de Geus, B.W.J.H. Penninx, G. Willemsen, K.T. Zondervan, K. Stefansson, R.F. Krueger, J.J. Lee, D.J. BenjaminD. Cesarini, P.D. Koellinger, M.A.H. den Hoed, H. Snieder, M.C. Mills

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Abstract

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

Original language	English
Pages (from-to)	1462-1472
Journal	Nature Genetics
Volume	48
Issue number	12
DOIs	https://doi.org/10.1038/ng.3698
Publication status	Published - 2016

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Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Willemsen, G., Zondervan, K. T., Stefansson, K., Krueger, R. F., Lee, J. J., ... Mills, M. C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48(12), 1462-1472. https://doi.org/10.1038/ng.3698

@article{516c8b5223644c46b1a0e446b0a6618a,

title = "Genome-wide analysis identifies 12 loci influencing human reproductive behavior.",

abstract = "The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.",

author = "N. Barban and R. Jansen and {de Vlaming}, Ronald and A. Vaez and J.J. Mandemakers and F.C. Tropf and X. Shen and J.F. Wilson and D.I. Chasman and I.M. Nolte and H. Mbarek and D.I. Boomsma and {de Geus}, E.J.C. and B.W.J.H. Penninx and G. Willemsen and K.T. Zondervan and K. Stefansson and R.F. Krueger and J.J. Lee and D.J. Benjamin and D. Cesarini and P.D. Koellinger and {den Hoed}, M.A.H. and H. Snieder and M.C. Mills",

year = "2016",

doi = "10.1038/ng.3698",

language = "English",

volume = "48",

pages = "1462--1472",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "12",

}

Barban, N, Jansen, R, de Vlaming, R, Vaez, A, Mandemakers, JJ, Tropf, FC, Shen, X, Wilson, JF, Chasman, DI, Nolte, IM, Mbarek, H, Boomsma, DI , de Geus, EJC, Penninx, BWJH, Willemsen, G, Zondervan, KT, Stefansson, K, Krueger, RF, Lee, JJ, Benjamin, DJ, Cesarini, D, Koellinger, PD, den Hoed, MAH, Snieder, H & Mills, MC 2016, 'Genome-wide analysis identifies 12 loci influencing human reproductive behavior.', Nature Genetics, vol. 48, no. 12, pp. 1462-1472. https://doi.org/10.1038/ng.3698

TY - JOUR

T1 - Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

AU - Barban, N.

AU - Jansen, R.

AU - de Vlaming, Ronald

AU - Vaez, A.

AU - Mandemakers, J.J.

AU - Tropf, F.C.

AU - Shen, X.

AU - Wilson, J.F.

AU - Chasman, D.I.

AU - Nolte, I.M.

AU - Mbarek, H.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

AU - Penninx, B.W.J.H.

AU - Willemsen, G.

AU - Zondervan, K.T.

AU - Stefansson, K.

AU - Krueger, R.F.

AU - Lee, J.J.

AU - Benjamin, D.J.

AU - Cesarini, D.

AU - Koellinger, P.D.

AU - den Hoed, M.A.H.

AU - Snieder, H.

AU - Mills, M.C.

PY - 2016

Y1 - 2016

N2 - The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

AB - The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

U2 - 10.1038/ng.3698

DO - 10.1038/ng.3698

M3 - Article

SN - 1061-4036

VL - 48

SP - 1462

EP - 1472

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Abstract

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