Genome-wide association analysis identifies multiple loci related to resting heart rate

M. Eijgelsheim, C. Newton-Cheh, N. Sotoodehnia, P.I.W. Bakker, M. Müller, A.C. Morrison, A.V. Smith, A. Isaacs, S. Sanna, M. Dörr, P. Navarro, C. Fuchsberger, I.M. Nolte, E.J.C. de Geus, K. Estrada, S.J. Hwang, J.C. Bis, I.M. Rückert, A. Alonso, L.J. LaunerJ.J. Hottenga, F. Rivadeneira, P.A. Noseworthy, T.A. Rice, S. Perz, D.E. Arking, T.D. Spector, J.A. Kors, Y.S. Aulchenko, K.V. Tarasov, G. Homuth, S.H. Wild, F. Marroni, C. Gieger, C.M.M. Licht, R.J. Prineas, A. Hofman, J.I. Rotter, A.A. Hicks, F. Ernst, S.S. Najjar, A.F. Wright, A. Peters, E.R. Fox, B.A. Oostra, H.K. Kroemer, D. Couper, H. Völzke, H. Campbell, T. Meitinger, M. Uda, J.C.M. Witteman, B.M. Psaty, H.-E. Wichmann, T.B. Harris, S. Kääb, D.S. Siscovick, Y. Jamshidi, A.G. Uitterlinden, A.R. Folsom, M.G. Larson, J.F. Wilson, B.W.J.H. Penninx, H. Snieder, P.P. Pramstaller, C.M. van Duijn, E.G. Lakatta, S.B. Felix, V. Gudnason, A. Pfeufer, S.R. Heckbert, B.H.C. Stricker, E. Boerwinkle, C.J. O'Donnell

Research output: Contribution to JournalArticle

Abstract

Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving our understanding of the physiology of heart rate regulation. To identify common genetic variants associated with heart rate, we performed a meta-analysis of 15 genome-wide association studies (GWAS), including 38 991 subjects of European ancestry, estimating the association between age-, sex-and body mass-adjusted RR interval (inverse heart rate) and ~2.5 million markers. Results with P < 5 × 10
Original languageEnglish
Pages (from-to)3885-3894
JournalHuman Molecular Genetics
Volume19
Issue number19
DOIs
Publication statusPublished - 2010

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Eijgelsheim, M., Newton-Cheh, C., Sotoodehnia, N., Bakker, P. I. W., Müller, M., Morrison, A. C., ... O'Donnell, C. J. (2010). Genome-wide association analysis identifies multiple loci related to resting heart rate. Human Molecular Genetics, 19(19), 3885-3894. https://doi.org/10.1093/hmg/ddq303