Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

N. Amin; E. Byrne; J. Johnson; G. Chenevix-Trench; S. Walter; I.M. Nolte; J.M. Vink; R. Rawal; M. Mangino; A. Teumer; J.C. Keers; G. Verwoert; S. Baumeister; R. Biffar; A. Petersmann; N. Dahmen; A. Doering; A. Isaacs; L. Broer; N.R. Wray; G.W. Montgomery; D. Levy; B.M. Psaty; V. Gudnason; A. Chakravarti; P. Sulem; D.F. Gudbjartsson; L.A. Kiemeney; U. Thorsteinsdottir; K. Stefansson; F.J.A. van Rooij; Y.S. Aulchenko; F. Rivadeneira; A. Hofman; A.G. Uitterlinden; C.J. Hammond; S.Y. Shin; M. Arfan Ikram; J.C.M. Witteman; A.C.J.W. Janssens; H. Snieder; H. Tiemeier; B.H.R. Wolfenbuttel; B.A. Oostra; A.C. Heath; E. Wichmann; T.D. Spector; H.J. Grabe; D.I. Boomsma; N.G. Martin; C.M. van Duijn

doi:10.1038/mp.2011.101

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

N. Amin, E. Byrne, J. Johnson, G. Chenevix-Trench, S. Walter, I.M. Nolte, J.M. Vink, R. Rawal, M. Mangino, A. Teumer, J.C. Keers, G. Verwoert, S. Baumeister, R. Biffar, A. Petersmann, N. Dahmen, A. Doering, A. Isaacs, L. Broer, N.R. WrayG.W. Montgomery, D. Levy, B.M. Psaty, V. Gudnason, A. Chakravarti, P. Sulem, D.F. Gudbjartsson, L.A. Kiemeney, U. Thorsteinsdottir, K. Stefansson, F.J.A. van Rooij, Y.S. Aulchenko, F. Rivadeneira, A. Hofman, A.G. Uitterlinden, C.J. Hammond, S.Y. Shin, M. Arfan Ikram, J.C.M. Witteman, A.C.J.W. Janssens, H. Snieder, H. Tiemeier, B.H.R. Wolfenbuttel, B.A. Oostra, A.C. Heath, E. Wichmann, T.D. Spector, H.J. Grabe, D.I. Boomsma, N.G. Martin, C.M. van Duijn

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two single-nucleotide polymorphisms (SNPs) in the 15q24 region. The two SNPs rs2470893 and rs2472297 (P-values1.6 × 10

Original language	English
Pages (from-to)	1116-1129
Journal	Molecular Psychiatry
Volume	17
Issue number	11
DOIs	https://doi.org/10.1038/mp.2011.101
Publication status	Published - 2012

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Netherlands Twin Register (NTR)

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Amin, N., Byrne, E., Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I. M., Vink, J. M., Rawal, R., Mangino, M., Teumer, A., Keers, J. C., Verwoert, G., Baumeister, S., Biffar, R., Petersmann, A., Dahmen, N., Doering, A., Isaacs, A., Broer, L., ... van Duijn, C. M. (2012). Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry, 17(11), 1116-1129. https://doi.org/10.1038/mp.2011.101

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title = "Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM",

abstract = "Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two single-nucleotide polymorphisms (SNPs) in the 15q24 region. The two SNPs rs2470893 and rs2472297 (P-values1.6 × 10",

author = "N. Amin and E. Byrne and J. Johnson and G. Chenevix-Trench and S. Walter and I.M. Nolte and J.M. Vink and R. Rawal and M. Mangino and A. Teumer and J.C. Keers and G. Verwoert and S. Baumeister and R. Biffar and A. Petersmann and N. Dahmen and A. Doering and A. Isaacs and L. Broer and N.R. Wray and G.W. Montgomery and D. Levy and B.M. Psaty and V. Gudnason and A. Chakravarti and P. Sulem and D.F. Gudbjartsson and L.A. Kiemeney and U. Thorsteinsdottir and K. Stefansson and {van Rooij}, F.J.A. and Y.S. Aulchenko and F. Rivadeneira and A. Hofman and A.G. Uitterlinden and C.J. Hammond and S.Y. Shin and {Arfan Ikram}, M. and J.C.M. Witteman and A.C.J.W. Janssens and H. Snieder and H. Tiemeier and B.H.R. Wolfenbuttel and B.A. Oostra and A.C. Heath and E. Wichmann and T.D. Spector and H.J. Grabe and D.I. Boomsma and N.G. Martin and {van Duijn}, C.M.",

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doi = "10.1038/mp.2011.101",

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Amin, N, Byrne, E, Johnson, J, Chenevix-Trench, G, Walter, S, Nolte, IM, Vink, JM, Rawal, R, Mangino, M, Teumer, A, Keers, JC, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N, Doering, A, Isaacs, A, Broer, L, Wray, NR, Montgomery, GW, Levy, D, Psaty, BM, Gudnason, V, Chakravarti, A, Sulem, P, Gudbjartsson, DF, Kiemeney, LA, Thorsteinsdottir, U, Stefansson, K, van Rooij, FJA, Aulchenko, YS, Rivadeneira, F, Hofman, A, Uitterlinden, AG, Hammond, CJ, Shin, SY, Arfan Ikram, M, Witteman, JCM, Janssens, ACJW, Snieder, H, Tiemeier, H, Wolfenbuttel, BHR, Oostra, BA, Heath, AC, Wichmann, E, Spector, TD, Grabe, HJ, Boomsma, DI, Martin, NG & van Duijn, CM 2012, 'Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM', Molecular Psychiatry, vol. 17, no. 11, pp. 1116-1129. https://doi.org/10.1038/mp.2011.101

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T1 - Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

AU - Amin, N.

AU - Byrne, E.

AU - Johnson, J.

AU - Chenevix-Trench, G.

AU - Walter, S.

AU - Nolte, I.M.

AU - Vink, J.M.

AU - Rawal, R.

AU - Mangino, M.

AU - Teumer, A.

AU - Keers, J.C.

AU - Verwoert, G.

AU - Baumeister, S.

AU - Biffar, R.

AU - Petersmann, A.

AU - Dahmen, N.

AU - Doering, A.

AU - Isaacs, A.

AU - Broer, L.

AU - Wray, N.R.

AU - Montgomery, G.W.

AU - Levy, D.

AU - Psaty, B.M.

AU - Gudnason, V.

AU - Chakravarti, A.

AU - Sulem, P.

AU - Gudbjartsson, D.F.

AU - Kiemeney, L.A.

AU - Thorsteinsdottir, U.

AU - Stefansson, K.

AU - van Rooij, F.J.A.

AU - Aulchenko, Y.S.

AU - Rivadeneira, F.

AU - Hofman, A.

AU - Uitterlinden, A.G.

AU - Hammond, C.J.

AU - Shin, S.Y.

AU - Arfan Ikram, M.

AU - Witteman, J.C.M.

AU - Janssens, A.C.J.W.

AU - Snieder, H.

AU - Tiemeier, H.

AU - Wolfenbuttel, B.H.R.

AU - Oostra, B.A.

AU - Heath, A.C.

AU - Wichmann, E.

AU - Spector, T.D.

AU - Grabe, H.J.

AU - Boomsma, D.I.

AU - Martin, N.G.

AU - van Duijn, C.M.

PY - 2012

Y1 - 2012

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AB - Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two single-nucleotide polymorphisms (SNPs) in the 15q24 region. The two SNPs rs2470893 and rs2472297 (P-values1.6 × 10

U2 - 10.1038/mp.2011.101

DO - 10.1038/mp.2011.101

M3 - Article

SN - 1359-4184

VL - 17

SP - 1116

EP - 1129

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 11

ER -

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

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