Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

N. Amin, E. Byrne, J. Johnson, G. Chenevix-Trench, S. Walter, I.M. Nolte, J.M. Vink, R. Rawal, M. Mangino, A. Teumer, J.C. Keers, G. Verwoert, S. Baumeister, R. Biffar, A. Petersmann, N. Dahmen, A. Doering, A. Isaacs, L. Broer, N.R. WrayG.W. Montgomery, D. Levy, B.M. Psaty, V. Gudnason, A. Chakravarti, P. Sulem, D.F. Gudbjartsson, L.A. Kiemeney, U. Thorsteinsdottir, K. Stefansson, F.J.A. van Rooij, Y.S. Aulchenko, F. Rivadeneira, A. Hofman, A.G. Uitterlinden, C.J. Hammond, S.Y. Shin, M. Arfan Ikram, J.C.M. Witteman, A.C.J.W. Janssens, H. Snieder, H. Tiemeier, B.H.R. Wolfenbuttel, B.A. Oostra, A.C. Heath, E. Wichmann, T.D. Spector, H.J. Grabe, D.I. Boomsma, N.G. Martin, C.M. van Duijn

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two single-nucleotide polymorphisms (SNPs) in the 15q24 region. The two SNPs rs2470893 and rs2472297 (P-values1.6 × 10
Original languageEnglish
Pages (from-to)1116-1129
JournalMolecular Psychiatry
Volume17
Issue number11
DOIs
Publication statusPublished - 2012

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