Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

G. Schumann; L.J.M. Coin; A. Lourdusamy; P. Charoen; K.H. Berger; D. Stacey; S. Desrivières; F.A. Aliev; A.A. Khan; N. Amin; Y.S. Aulchenko; G. Bakalkin; S.J. Bakker; B. Balkau; J.W. Beulens; A. Bilbao; R.A. de Boer; D. Beury; M.L. Bots; E.J. Breetvelt; S. Cauchi; C. Cavalcanti-Proença; J.C. Chambers; T.K. Clarke; N. Dahmen; E.J.C. de Geus; D. Dick; F. Duccia; A. Easton; H.J. Edenberg; T. Esk; A. Fernández-Medarde; T. Foroud; N.B. Freimer; J.A. Girault; D.E. Grobbee; S. Guarreray; D.F. Gudbjartsson; A.-L. Hartikainen; A.C. Heath; V. Hesselbrock; A. Hofman; J.J. Hottenga; M. Isohanni; J. Kaprio; K.T. Khaw; B. Kuehnel; J. Laitinen; S. Lobbens; J. Luan; M. Mangino; M. Maroteau; B.A. Oostra; P.F. O’Reilly; B.W.J.H. Penninx; A. Pouta; I. Prokopenko; F. Ricceri; E. Santos; J.H. Smit; N. Soranzo; M. Stumvoll; I. Surakka; T.E. Thorgeirsson; U. Thorsteinsdottir; C. Troakes; T. Tyrfingsson; A. Tönjes; C.S. Uiterwaal; A.G. Uitterlinden; P. van der Harst; Y.T. van der Schouw; O. Staehlin; N. Vogelzangs; P. Vollenweider; G. Waeber; N.J. Wareham; D. Waterworth; J.B. Whitfield; H.E. Wichmann; G. Willemsen; J.C. Witteman; N.G. Martin; A. Metspalu; J. Scott; T.D. Spector; R.J. Loos; D.I. Boomsma; V. Mooser; L. Peltonen; K. Stefansson; C.M. van Duijn; P. Vineis; W.H. Sommer; J.S. Kooner; R. Spanagel; U.A. Heberlein; M.E. Numans; M.-R. Jarvelin; P. Elliott

doi:10.1073/pnas.1017288108

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

G. Schumann, L.J.M. Coin, A. Lourdusamy, P. Charoen, K.H. Berger, D. Stacey, S. Desrivières, F.A. Aliev, A.A. Khan, N. Amin, Y.S. Aulchenko, G. Bakalkin, S.J. Bakker, B. Balkau, J.W. Beulens, A. Bilbao, R.A. de Boer, D. Beury, M.L. Bots, E.J. BreetveltS. Cauchi, C. Cavalcanti-Proença, J.C. Chambers, T.K. Clarke, N. Dahmen, E.J.C. de Geus, D. Dick, F. Duccia, A. Easton, H.J. Edenberg, T. Esk, A. Fernández-Medarde, T. Foroud, N.B. Freimer, J.A. Girault, D.E. Grobbee, S. Guarreray, D.F. Gudbjartsson, A.-L. Hartikainen, A.C. Heath, V. Hesselbrock, A. Hofman, J.J. Hottenga, M. Isohanni, J. Kaprio, K.T. Khaw, B. Kuehnel, J. Laitinen, S. Lobbens, J. Luan, M. Mangino, M. Maroteau, B.A. Oostra, P.F. O’Reilly, B.W.J.H. Penninx, A. Pouta, I. Prokopenko, F. Ricceri, E. Santos, J.H. Smit, N. Soranzo, M. Stumvoll, I. Surakka, T.E. Thorgeirsson, U. Thorsteinsdottir, C. Troakes, T. Tyrfingsson, A. Tönjes, C.S. Uiterwaal, A.G. Uitterlinden, P. van der Harst, Y.T. van der Schouw, O. Staehlin, N. Vogelzangs, P. Vollenweider, G. Waeber, N.J. Wareham, D. Waterworth, J.B. Whitfield, H.E. Wichmann, G. Willemsen, J.C. Witteman, N.G. Martin, A. Metspalu, J. Scott, T.D. Spector, R.J. Loos, D.I. Boomsma, V. Mooser, L. Peltonen, K. Stefansson, C.M. van Duijn, P. Vineis, W.H. Sommer, J.S. Kooner, R. Spanagel, U.A. Heberlein, M.E. Numans, M.-R. Jarvelin, P. Elliott

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10

Original language	English
Pages (from-to)	7119-7124
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	108
Issue number	17
DOIs	https://doi.org/10.1073/pnas.1017288108
Publication status	Published - 2011

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Netherlands Twin Register (NTR)

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10.1073/pnas.1017288108

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Schumann, G., Coin, L. J. M., Lourdusamy, A., Charoen, P., Berger, K. H., Stacey, D., Desrivières, S., Aliev, F. A., Khan, A. A., Amin, N., Aulchenko, Y. S., Bakalkin, G., Bakker, S. J., Balkau, B., Beulens, J. W., Bilbao, A., de Boer, R. A., Beury, D., Bots, M. L., ... Elliott, P. (2011). Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7119-7124. https://doi.org/10.1073/pnas.1017288108

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title = "Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption",

abstract = "Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10",

author = "G. Schumann and L.J.M. Coin and A. Lourdusamy and P. Charoen and K.H. Berger and D. Stacey and S. Desrivi{\`e}res and F.A. Aliev and A.A. Khan and N. Amin and Y.S. Aulchenko and G. Bakalkin and S.J. Bakker and B. Balkau and J.W. Beulens and A. Bilbao and {de Boer}, R.A. and D. Beury and M.L. Bots and E.J. Breetvelt and S. Cauchi and C. Cavalcanti-Proen{\c c}a and J.C. Chambers and T.K. Clarke and N. Dahmen and {de Geus}, E.J.C. and D. Dick and F. Duccia and A. Easton and H.J. Edenberg and T. Esk and A. Fern{\'a}ndez-Medarde and T. Foroud and N.B. Freimer and J.A. Girault and D.E. Grobbee and S. Guarreray and D.F. Gudbjartsson and A.-L. Hartikainen and A.C. Heath and V. Hesselbrock and A. Hofman and J.J. Hottenga and M. Isohanni and J. Kaprio and K.T. Khaw and B. Kuehnel and J. Laitinen and S. Lobbens and J. Luan and M. Mangino and M. Maroteau and B.A. Oostra and P.F. O{\textquoteright}Reilly and B.W.J.H. Penninx and A. Pouta and I. Prokopenko and F. Ricceri and E. Santos and J.H. Smit and N. Soranzo and M. Stumvoll and I. Surakka and T.E. Thorgeirsson and U. Thorsteinsdottir and C. Troakes and T. Tyrfingsson and A. T{\"o}njes and C.S. Uiterwaal and A.G. Uitterlinden and {van der Harst}, P. and {van der Schouw}, Y.T. and O. Staehlin and N. Vogelzangs and P. Vollenweider and G. Waeber and N.J. Wareham and D. Waterworth and J.B. Whitfield and H.E. Wichmann and G. Willemsen and J.C. Witteman and N.G. Martin and A. Metspalu and J. Scott and T.D. Spector and R.J. Loos and D.I. Boomsma and V. Mooser and L. Peltonen and K. Stefansson and {van Duijn}, C.M. and P. Vineis and W.H. Sommer and J.S. Kooner and R. Spanagel and U.A. Heberlein and M.E. Numans and M.-R. Jarvelin and P. Elliott",

year = "2011",

doi = "10.1073/pnas.1017288108",

language = "English",

volume = "108",

pages = "7119--7124",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Acad Sciences",

number = "17",

}

Schumann, G, Coin, LJM, Lourdusamy, A, Charoen, P, Berger, KH, Stacey, D, Desrivières, S, Aliev, FA, Khan, AA, Amin, N, Aulchenko, YS, Bakalkin, G, Bakker, SJ, Balkau, B, Beulens, JW, Bilbao, A, de Boer, RA, Beury, D, Bots, ML, Breetvelt, EJ, Cauchi, S, Cavalcanti-Proença, C, Chambers, JC, Clarke, TK, Dahmen, N, de Geus, EJC, Dick, D, Duccia, F, Easton, A, Edenberg, HJ, Esk, T, Fernández-Medarde, A, Foroud, T, Freimer, NB, Girault, JA, Grobbee, DE, Guarreray, S, Gudbjartsson, DF, Hartikainen, A-L, Heath, AC, Hesselbrock, V, Hofman, A, Hottenga, JJ, Isohanni, M, Kaprio, J, Khaw, KT, Kuehnel, B, Laitinen, J, Lobbens, S, Luan, J, Mangino, M, Maroteau, M, Oostra, BA, O’Reilly, PF, Penninx, BWJH, Pouta, A, Prokopenko, I, Ricceri, F, Santos, E, Smit, JH, Soranzo, N, Stumvoll, M, Surakka, I, Thorgeirsson, TE, Thorsteinsdottir, U, Troakes, C, Tyrfingsson, T, Tönjes, A, Uiterwaal, CS, Uitterlinden, AG, van der Harst, P, van der Schouw, YT, Staehlin, O, Vogelzangs, N, Vollenweider, P, Waeber, G, Wareham, NJ, Waterworth, D, Whitfield, JB, Wichmann, HE, Willemsen, G, Witteman, JC, Martin, NG, Metspalu, A, Scott, J, Spector, TD, Loos, RJ, Boomsma, DI, Mooser, V, Peltonen, L, Stefansson, K, van Duijn, CM, Vineis, P, Sommer, WH, Kooner, JS, Spanagel, R, Heberlein, UA, Numans, ME, Jarvelin, M-R & Elliott, P 2011, 'Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 17, pp. 7119-7124. https://doi.org/10.1073/pnas.1017288108

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. / Schumann, G.; Coin, L.J.M.; Lourdusamy, A. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 17, 2011, p. 7119-7124.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

AU - Schumann, G.

AU - Coin, L.J.M.

AU - Lourdusamy, A.

AU - Charoen, P.

AU - Berger, K.H.

AU - Stacey, D.

AU - Desrivières, S.

AU - Aliev, F.A.

AU - Khan, A.A.

AU - Amin, N.

AU - Aulchenko, Y.S.

AU - Bakalkin, G.

AU - Bakker, S.J.

AU - Balkau, B.

AU - Beulens, J.W.

AU - Bilbao, A.

AU - de Boer, R.A.

AU - Beury, D.

AU - Bots, M.L.

AU - Breetvelt, E.J.

AU - Cauchi, S.

AU - Cavalcanti-Proença, C.

AU - Chambers, J.C.

AU - Clarke, T.K.

AU - Dahmen, N.

AU - de Geus, E.J.C.

AU - Dick, D.

AU - Duccia, F.

AU - Easton, A.

AU - Edenberg, H.J.

AU - Esk, T.

AU - Fernández-Medarde, A.

AU - Foroud, T.

AU - Freimer, N.B.

AU - Girault, J.A.

AU - Grobbee, D.E.

AU - Guarreray, S.

AU - Gudbjartsson, D.F.

AU - Hartikainen, A.-L.

AU - Heath, A.C.

AU - Hesselbrock, V.

AU - Hofman, A.

AU - Hottenga, J.J.

AU - Isohanni, M.

AU - Kaprio, J.

AU - Khaw, K.T.

AU - Kuehnel, B.

AU - Laitinen, J.

AU - Lobbens, S.

AU - Luan, J.

AU - Mangino, M.

AU - Maroteau, M.

AU - Oostra, B.A.

AU - O’Reilly, P.F.

AU - Penninx, B.W.J.H.

AU - Pouta, A.

AU - Prokopenko, I.

AU - Ricceri, F.

AU - Santos, E.

AU - Smit, J.H.

AU - Soranzo, N.

AU - Stumvoll, M.

AU - Surakka, I.

AU - Thorgeirsson, T.E.

AU - Thorsteinsdottir, U.

AU - Troakes, C.

AU - Tyrfingsson, T.

AU - Tönjes, A.

AU - Uiterwaal, C.S.

AU - Uitterlinden, A.G.

AU - van der Harst, P.

AU - van der Schouw, Y.T.

AU - Staehlin, O.

AU - Vogelzangs, N.

AU - Vollenweider, P.

AU - Waeber, G.

AU - Wareham, N.J.

AU - Waterworth, D.

AU - Whitfield, J.B.

AU - Wichmann, H.E.

AU - Willemsen, G.

AU - Witteman, J.C.

AU - Martin, N.G.

AU - Metspalu, A.

AU - Scott, J.

AU - Spector, T.D.

AU - Loos, R.J.

AU - Boomsma, D.I.

AU - Mooser, V.

AU - Peltonen, L.

AU - Stefansson, K.

AU - van Duijn, C.M.

AU - Vineis, P.

AU - Sommer, W.H.

AU - Kooner, J.S.

AU - Spanagel, R.

AU - Heberlein, U.A.

AU - Numans, M.E.

AU - Jarvelin, M.-R.

AU - Elliott, P.

PY - 2011

Y1 - 2011

N2 - Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10

AB - Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10

U2 - 10.1073/pnas.1017288108

DO - 10.1073/pnas.1017288108

M3 - Article

SN - 0027-8424

VL - 108

SP - 7119

EP - 7124

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 17

ER -

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Abstract

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UN SDGs

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