Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

G. Schumann, L.J.M. Coin, A. Lourdusamy, P. Charoen, K.H. Berger, D. Stacey, S. Desrivières, F.A. Aliev, A.A. Khan, N. Amin, Y.S. Aulchenko, G. Bakalkin, S.J. Bakker, B. Balkau, J.W. Beulens, A. Bilbao, R.A. de Boer, D. Beury, M.L. Bots, E.J. BreetveltS. Cauchi, C. Cavalcanti-Proença, J.C. Chambers, T.K. Clarke, N. Dahmen, E.J.C. de Geus, D. Dick, F. Duccia, A. Easton, H.J. Edenberg, T. Esk, A. Fernández-Medarde, T. Foroud, N.B. Freimer, J.A. Girault, D.E. Grobbee, S. Guarreray, D.F. Gudbjartsson, A.-L. Hartikainen, A.C. Heath, V. Hesselbrock, A. Hofman, J.J. Hottenga, M. Isohanni, J. Kaprio, K.T. Khaw, B. Kuehnel, J. Laitinen, S. Lobbens, J. Luan, M. Mangino, M. Maroteau, B.A. Oostra, P.F. O’Reilly, B.W.J.H. Penninx, A. Pouta, I. Prokopenko, F. Ricceri, E. Santos, J.H. Smit, N. Soranzo, M. Stumvoll, I. Surakka, T.E. Thorgeirsson, U. Thorsteinsdottir, C. Troakes, T. Tyrfingsson, A. Tönjes, C.S. Uiterwaal, A.G. Uitterlinden, P. van der Harst, Y.T. van der Schouw, O. Staehlin, N. Vogelzangs, P. Vollenweider, G. Waeber, N.J. Wareham, D. Waterworth, J.B. Whitfield, H.E. Wichmann, G. Willemsen, J.C. Witteman, N.G. Martin, A. Metspalu, J. Scott, T.D. Spector, R.J. Loos, D.I. Boomsma, V. Mooser, L. Peltonen, K. Stefansson, C.M. van Duijn, P. Vineis, W.H. Sommer, J.S. Kooner, R. Spanagel, U.A. Heberlein, M.E. Numans, M.-R. Jarvelin, P. Elliott

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10
Original languageEnglish
Pages (from-to)7119-7124
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number17
DOIs
Publication statusPublished - 2011

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