Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth pubertal timing and childhood adiposity

D.L. Cousminer, D.J. Berry, N.J. Timpson, W. Ang, E. Thiering, E.M. Byrne, H.R. Taal, V. Huikari, J.P. Bradfield, M. Kerkhof, M.M. Groen-Blokhuis, E. Kreiner-Møller, M. Marinelli, C. Holst, J.T. Leinonen, J.R. Perry, I. Surakka, O.P. Pietilainen, J. Kettunen, V. AnttilaM. Kaakinen, U. Sovio, A. Pouta, S. Das, V. Lagou, C. Power, I. Prokopenko, D.M. Evans, J.P. Kemp, B. St Pourcain, S.M. Ring, A. Palotie, E. Kajantie, C. Osmond, T. Lehtimäki, J.S. Viikari, M. Kähönen, N.M. Warrington, S.J. Lye, L.J. Palmer, C.M.T. Tiesler, C. Flexeder, G.W. Montgomery, S.E. Medland, A. Hofman, H. Hakonarson, M. Guxens, M. Bartels, V. Salomaa, L.S. Adair, M. Atalay, C.E.M. van Beijsterveldt, N. Bergen, K.S. Benke, P. Charoen, L. Coin, C. Cooper, O.S. Davis, G.V. Dedoussis, P. Elliott, X. Estivill, B. Feenstra, T.M. Frayling, R.M. Freathy, R. Gaillard, F. Geller, M.W. Gillman, L.K. Goh, A.T. Hattersley, C.M. Haworth, D. Hadley, J. Hedebrand, A. Hinney, J.N. Hirschhorn, B. Hocher, J.W. Holloway, J.J. Hottenga, M. Horikoshi, C. Iñiguez, M.R. Järvelin, T.O. Kilpeläinen, M. Kirin, M. Kowgier, H.M. Lakka, T.A. Lakka, L.A. Lange, D.A. Lawlor, A. Lewin, C.M. Lindgren, V. Lindi, R. Maggi, J. Marsh, M. Melbye, C.M. Middeldorp, I. Millwood, K.L. Mohlke, D.O. Mook-Kanamori, J.C. Murray, M.G. Nivard, E.A. Nohr, I. Ntalla, E. Oken, K.K. Ong, P.F. O'Reilly, K. Panoutsopoulou, J. Pararajasingham, E.R. Pearson, T.S. Price, A. Rodriguez, R.M. Salem, S.M. Saw, A. Scherag, S. Sebert, N. Siitonen, O. Simell, D.P. Strachan, J. Sunyer, Y.Y. Teo, A.G. Uitterlinden, B. Valcárcel, S. White, E. Widén, G. Willemsen, J.F. Wilson, H. Yaghootkar, E. Zeggini, C.E. Elks, P. Sulem, D.I. Chasman, N. Franceschini, C. He, K.L. Lunetta, J.A. Visser, D.F. Gudbjartsson, T. Esko, D.L. Koller, Z. Kutalik, P. Lin, M. Mangino, M. Marongiu, P.F. McArdle, A.V. Smith, L. Stolk, S. van Wingerden, J.H. Zhao, E. Albrecht, T. Corre, E. Ingelsson, C. Hayward, P.K.E. Magnusson, E.N. Smith, S. Ulivi, M. Warrington, L. Zgaga, H. Alavere, N. Amin, T. Aspelund, S. Bandinelli, I. Barroso, G.S. Berenson, S. Bergmann, H. Blackburn, E. Boerwinkle, J.E. Buring, F. Busonero, H. Campbell, S.J. Chanock, W. Chen, M.C. Cornelis, D. Couper, A.D. Coviello, P. d'Adamo, U. de Faire, E.J.C. de Geus, P. Deloukas, A. Döring, G. Davey Smith, D.F. Easton, G. Eiriksdottir, V. Emilsson, L. Ferrucci, A.R. Folsom, T. Foroud, M. Garcia, P. Gasparini, C. Gieger, V. Gudnason, P. Hall, S.E. Hankinson, L. Ferreli, A.C. Heath, D.G. Hernandez, F.B. Hu, T. Illig, A.D. Johnson, D. Karasik, K.T. Khaw, D.P. Kiel, I. Kolcic, P. Kraft, L.J. Launer, J.S. Laven, S. Li, J. Liu, D. Levy, W.L. McArdle, V. Mooser, S.S. Murray, M.A. Nalls, P. Navarro, M. Nelis, A.R. Ness, K. Northstone, B.A. Oostra, M. Peacock, G. Paré, A.N. Parker, N.L. Pedersen, L. Peltonen, C.E. Pennell, P. Pharoah, O. Polasek, A.S. Plump, E. Porcu, T. Rafnar, J.P. Rice, F. Rivadeneira, I. Rudan, C. Sala, S. Sanna, D. Schlessinger, N.J. Schork, A. Scuteri, A.V. Segrè, A.R. Shuldiner, N. Soranzo, S.R. Srinivasan, M.L. Tammesoo, E. Tikkanen, D. Toniolo, K. Tsui, L. Tryggvadottir, J. Tyrer, M. Uda, R.M. Dam, J.B. van Meurs, P. Vollenweider, G. Waeber, N.J. Wareham, D. Waterworth, M.N. Weedon, H.E. Wichmann, A.F. Wright, L. Young, G. Zhai, W.V. Zhuang, L.J. Bierut, H.A. Boyd, L. Crisponi, E.W. Demerath, C.M. van Duijn, M.J. Econs, T.B. Harris, D.J. Hunter, R.J. Loos, A. Metspalu, P.M. Ridker, T.D. Spector, E.A. Streeten, K. Stefansson, U. Thorsteinsdottir, A. Murray, J.M. Murabito, J. Kaprio, T.I.A. Sørensen, F. Ballester, H. Bisgaard, D.I. Boomsma, G.H. Koppelman, S.F. Grant, V.W. Jaddoe, N.G. Martin, J. Heinrich, O.T. Raitakari, J.G. Eriksson, G.D. Smith, E. Hyppönen, M.I. McCarthy, S. Ripatti

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growthfactors.Although little is knownabout the underlying genetics,growthvariabilityduring puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associatedwith pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlyingmechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth andmaturation, we performed genome-wide association meta-analyses in 18 737 European samples utilizing longitudinally collected height measurements. We found significant associations (P < 1.67 3 10
Original languageEnglish
Pages (from-to)2735-2747
JournalHuman Molecular Genetics
Volume22
Issue number13
DOIs
Publication statusPublished - 2013

    Fingerprint

Cite this

Cousminer, D. L., Berry, D. J., Timpson, N. J., Ang, W., Thiering, E., Byrne, E. M., ... Ripatti, S. (2013). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth pubertal timing and childhood adiposity. Human Molecular Genetics, 22(13), 2735-2747. https://doi.org/10.1093/hmg/ddt104