Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

J. Deelen; M. Beekman; H.W. Uh; L. Broer; K.L. Ayers; Q. Tan; Y. Kamatani; A.M. Bennet; R. Tamm; S. Trompet; D.F. Gudbjartsson; F. Flachsbart; G. Rose; A. Viktorin; K. Fischer; M. Nygaard; H.J. Cordell; P. Crocco; E.B. van den Akker; S. Böhringer; Q. Helmer; C.P. Nelson; G.I. Saunders; M. Alver; K. Andersen-Ranberg; M.E. Breen; R. van der Breggen; A. Caliebe; M. Capri; E. Cevenini; J.C. Collerton; S. Dato; K. Davies; I. Ford; J. Gampe; P. Garagnani; E.J.C. de Geus; J. Harrow; D. van Heemst; B.T. Heijmans; F.A. Heinsen; J.J. Hottenga; A. Hofman; B. Jeune; P.V. Jonsson; M. Lathrop; D. Lechner; C. Martin-Ruiz; S.E. McNerlan; E. Mihailov; A. Montesanto; S.P. Mooijaart; A. Murphy; E.A. Nohr; L. Paternoster; I. Postmus; F. Rivadeneira; O.A. Ross; S. Salvioli; N. Sattar; S Schreiber; H. Stefansson; D.J. Stott; H. Tiemeier; A.G. Uitterlinden; R.G.J. Westendorp; G. Willemsen; N.J. Samani; P. Galan; T.I.A. Sørensen; D.I. Boomsma; J.W. Jukema; I. Maeve Rea; G. Passarino; A.J. de Craen; K. Christensen; A. Nebel; K. Stefansson; A. Metspalu; P. Magnusson; H. Blanché; L. Christiansen; T.B.L. Kirkwood; C.M. van Duijn; C. Franceschi; J.J. Houwing-Duistermaat; P.E. Slagboom

doi:10.1093/hmg/ddu139

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

J. Deelen, M. Beekman, H.W. Uh, L. Broer, K.L. Ayers, Q. Tan, Y. Kamatani, A.M. Bennet, R. Tamm, S. Trompet, D.F. Gudbjartsson, F. Flachsbart, G. Rose, A. Viktorin, K. Fischer, M. Nygaard, H.J. Cordell, P. Crocco, E.B. van den Akker, S. BöhringerQ. Helmer, C.P. Nelson, G.I. Saunders, M. Alver, K. Andersen-Ranberg, M.E. Breen, R. van der Breggen, A. Caliebe, M. Capri, E. Cevenini, J.C. Collerton, S. Dato, K. Davies, I. Ford, J. Gampe, P. Garagnani, E.J.C. de Geus, J. Harrow, D. van Heemst, B.T. Heijmans, F.A. Heinsen, J.J. Hottenga, A. Hofman, B. Jeune, P.V. Jonsson, M. Lathrop, D. Lechner, C. Martin-Ruiz, S.E. McNerlan, E. Mihailov, A. Montesanto, S.P. Mooijaart, A. Murphy, E.A. Nohr, L. Paternoster, I. Postmus, F. Rivadeneira, O.A. Ross, S. Salvioli, N. Sattar, S Schreiber, H. Stefansson, D.J. Stott, H. Tiemeier, A.G. Uitterlinden, R.G.J. Westendorp, G. Willemsen, N.J. Samani, P. Galan, T.I.A. Sørensen, D.I. Boomsma, J.W. Jukema, I. Maeve Rea, G. Passarino, A.J. de Craen, K. Christensen, A. Nebel, K. Stefansson, A. Metspalu, P. Magnusson, H. Blanché, L. Christiansen, T.B.L. Kirkwood, C.M. van Duijn, C. Franceschi, J.J. Houwing-Duistermaat, P.E. Slagboom

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The genetic contribution to the variation in human lifespan is ~25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥90 years. We observed genomewide significant association with longevity, as reflected by survival to ages beyond 90 years, at a novel locus, rs2149954, on chromosome 5q33.3 (OR =1.10, P = 1.74 × 10

Original language	English
Pages (from-to)	4420-4432
Number of pages	13
Journal	Human Molecular Genetics
Volume	23
Issue number	16
DOIs	https://doi.org/10.1093/hmg/ddu139
Publication status	Published - 2014

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UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Deelen, J., Beekman, M., Uh, H. W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Gudbjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., van den Akker, E. B., ... Slagboom, P. E. (2014). Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics, 23(16), 4420-4432. https://doi.org/10.1093/hmg/ddu139

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title = "Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age",

abstract = "The genetic contribution to the variation in human lifespan is ~25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥90 years. We observed genomewide significant association with longevity, as reflected by survival to ages beyond 90 years, at a novel locus, rs2149954, on chromosome 5q33.3 (OR =1.10, P = 1.74 × 10",

author = "J. Deelen and M. Beekman and H.W. Uh and L. Broer and K.L. Ayers and Q. Tan and Y. Kamatani and A.M. Bennet and R. Tamm and S. Trompet and D.F. Gudbjartsson and F. Flachsbart and G. Rose and A. Viktorin and K. Fischer and M. Nygaard and H.J. Cordell and P. Crocco and {van den Akker}, E.B. and S. B{\"o}hringer and Q. Helmer and C.P. Nelson and G.I. Saunders and M. Alver and K. Andersen-Ranberg and M.E. Breen and {van der Breggen}, R. and A. Caliebe and M. Capri and E. Cevenini and J.C. Collerton and S. Dato and K. Davies and I. Ford and J. Gampe and P. Garagnani and {de Geus}, E.J.C. and J. Harrow and {van Heemst}, D. and B.T. Heijmans and F.A. Heinsen and J.J. Hottenga and A. Hofman and B. Jeune and P.V. Jonsson and M. Lathrop and D. Lechner and C. Martin-Ruiz and S.E. McNerlan and E. Mihailov and A. Montesanto and S.P. Mooijaart and A. Murphy and E.A. Nohr and L. Paternoster and I. Postmus and F. Rivadeneira and O.A. Ross and S. Salvioli and N. Sattar and S Schreiber and H. Stefansson and D.J. Stott and H. Tiemeier and A.G. Uitterlinden and R.G.J. Westendorp and G. Willemsen and N.J. Samani and P. Galan and T.I.A. S{\o}rensen and D.I. Boomsma and J.W. Jukema and {Maeve Rea}, I. and G. Passarino and {de Craen}, A.J. and K. Christensen and A. Nebel and K. Stefansson and A. Metspalu and P. Magnusson and H. Blanch{\'e} and L. Christiansen and T.B.L. Kirkwood and {van Duijn}, C.M. and C. Franceschi and J.J. Houwing-Duistermaat and P.E. Slagboom",

year = "2014",

doi = "10.1093/hmg/ddu139",

language = "English",

volume = "23",

pages = "4420--4432",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "16",

}

Deelen, J, Beekman, M, Uh, HW, Broer, L, Ayers, KL, Tan, Q, Kamatani, Y, Bennet, AM, Tamm, R, Trompet, S, Gudbjartsson, DF, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, HJ, Crocco, P, van den Akker, EB, Böhringer, S, Helmer, Q, Nelson, CP, Saunders, GI, Alver, M, Andersen-Ranberg, K, Breen, ME, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, JC, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, EJC, Harrow, J, van Heemst, D, Heijmans, BT, Heinsen, FA, Hottenga, JJ, Hofman, A, Jeune, B, Jonsson, PV, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, SE, Mihailov, E, Montesanto, A, Mooijaart, SP, Murphy, A, Nohr, EA, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, OA, Salvioli, S, Sattar, N, Schreiber, S, Stefansson, H, Stott, DJ, Tiemeier, H, Uitterlinden, AG, Westendorp, RGJ, Willemsen, G, Samani, NJ, Galan, P, Sørensen, TIA, Boomsma, DI, Jukema, JW, Maeve Rea, I, Passarino, G, de Craen, AJ, Christensen, K, Nebel, A, Stefansson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, TBL, van Duijn, CM, Franceschi, C, Houwing-Duistermaat, JJ & Slagboom, PE 2014, 'Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age', Human Molecular Genetics, vol. 23, no. 16, pp. 4420-4432. https://doi.org/10.1093/hmg/ddu139

TY - JOUR

T1 - Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

AU - Deelen, J.

AU - Beekman, M.

AU - Uh, H.W.

AU - Broer, L.

AU - Ayers, K.L.

AU - Tan, Q.

AU - Kamatani, Y.

AU - Bennet, A.M.

AU - Tamm, R.

AU - Trompet, S.

AU - Gudbjartsson, D.F.

AU - Flachsbart, F.

AU - Rose, G.

AU - Viktorin, A.

AU - Fischer, K.

AU - Nygaard, M.

AU - Cordell, H.J.

AU - Crocco, P.

AU - van den Akker, E.B.

AU - Böhringer, S.

AU - Helmer, Q.

AU - Nelson, C.P.

AU - Saunders, G.I.

AU - Alver, M.

AU - Andersen-Ranberg, K.

AU - Breen, M.E.

AU - van der Breggen, R.

AU - Caliebe, A.

AU - Capri, M.

AU - Cevenini, E.

AU - Collerton, J.C.

AU - Dato, S.

AU - Davies, K.

AU - Ford, I.

AU - Gampe, J.

AU - Garagnani, P.

AU - de Geus, E.J.C.

AU - Harrow, J.

AU - van Heemst, D.

AU - Heijmans, B.T.

AU - Heinsen, F.A.

AU - Hottenga, J.J.

AU - Hofman, A.

AU - Jeune, B.

AU - Jonsson, P.V.

AU - Lathrop, M.

AU - Lechner, D.

AU - Martin-Ruiz, C.

AU - McNerlan, S.E.

AU - Mihailov, E.

AU - Montesanto, A.

AU - Mooijaart, S.P.

AU - Murphy, A.

AU - Nohr, E.A.

AU - Paternoster, L.

AU - Postmus, I.

AU - Rivadeneira, F.

AU - Ross, O.A.

AU - Salvioli, S.

AU - Sattar, N.

AU - Schreiber, S

AU - Stefansson, H.

AU - Stott, D.J.

AU - Tiemeier, H.

AU - Uitterlinden, A.G.

AU - Westendorp, R.G.J.

AU - Willemsen, G.

AU - Samani, N.J.

AU - Galan, P.

AU - Sørensen, T.I.A.

AU - Boomsma, D.I.

AU - Jukema, J.W.

AU - Maeve Rea, I.

AU - Passarino, G.

AU - de Craen, A.J.

AU - Christensen, K.

AU - Nebel, A.

AU - Stefansson, K.

AU - Metspalu, A.

AU - Magnusson, P.

AU - Blanché, H.

AU - Christiansen, L.

AU - Kirkwood, T.B.L.

AU - van Duijn, C.M.

AU - Franceschi, C.

AU - Houwing-Duistermaat, J.J.

AU - Slagboom, P.E.

PY - 2014

Y1 - 2014

N2 - The genetic contribution to the variation in human lifespan is ~25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥90 years. We observed genomewide significant association with longevity, as reflected by survival to ages beyond 90 years, at a novel locus, rs2149954, on chromosome 5q33.3 (OR =1.10, P = 1.74 × 10

AB - The genetic contribution to the variation in human lifespan is ~25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥90 years. We observed genomewide significant association with longevity, as reflected by survival to ages beyond 90 years, at a novel locus, rs2149954, on chromosome 5q33.3 (OR =1.10, P = 1.74 × 10

U2 - 10.1093/hmg/ddu139

DO - 10.1093/hmg/ddu139

M3 - Article

SN - 0964-6906

VL - 23

SP - 4420

EP - 4432

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 16

ER -

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

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