Genome-wide association scan for five major dimensions of personality

A. Terracciano; S. Sanna; M. Uda; B. Deiana; G. Usala; F. Busonero; A. Maschio; M. Scally; N. Patriciu; W.-M. Chen; M.A. Distel; P.E. Slagboom; D.I. Boomsma; S. Villafuerte; E. Sliwerska; M. Burmeister; N. Amin; A.C.J.W. Janssens; C.M. van Duijn; D. Schlessinger; G.R. Abecasis; P.T. Costa

doi:10.1038/mp.2008.113

Genome-wide association scan for five major dimensions of personality

A. Terracciano, S. Sanna, M. Uda, B. Deiana, G. Usala, F. Busonero, A. Maschio, M. Scally, N. Patriciu, W.-M. Chen, M.A. Distel, P.E. Slagboom, D.I. Boomsma, S. Villafuerte, E. Sliwerska, M. Burmeister, N. Amin, A.C.J.W. Janssens, C.M. van Duijn, D. SchlessingerG.R. Abecasis, P.T. Costa

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of 3972 individuals from a genetically isolated population within Sardinia, Italy. On the basis of the analyses of 362 129 single-nucleotide polymorphisms we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of neuroticism with SNAP25 (rs362584, P=5 × 10

Original language	English
Pages (from-to)	647-656
Journal	Molecular Psychiatry
Volume	15
Issue number	6
DOIs	https://doi.org/10.1038/mp.2008.113
Publication status	Published - 2010

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Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F., Maschio, A., Scally, M., Patriciu, N., Chen, W-M., Distel, M. A., Slagboom, P. E., Boomsma, D. I., Villafuerte, S., Sliwerska, E., Burmeister, M., Amin, N., Janssens, A. C. J. W., van Duijn, C. M., ... Costa, P. T. (2010). Genome-wide association scan for five major dimensions of personality. Molecular Psychiatry, 15(6), 647-656. https://doi.org/10.1038/mp.2008.113

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title = "Genome-wide association scan for five major dimensions of personality",

abstract = "Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of 3972 individuals from a genetically isolated population within Sardinia, Italy. On the basis of the analyses of 362 129 single-nucleotide polymorphisms we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of neuroticism with SNAP25 (rs362584, P=5 × 10",

author = "A. Terracciano and S. Sanna and M. Uda and B. Deiana and G. Usala and F. Busonero and A. Maschio and M. Scally and N. Patriciu and W.-M. Chen and M.A. Distel and P.E. Slagboom and D.I. Boomsma and S. Villafuerte and E. Sliwerska and M. Burmeister and N. Amin and A.C.J.W. Janssens and {van Duijn}, C.M. and D. Schlessinger and G.R. Abecasis and P.T. Costa",

year = "2010",

doi = "10.1038/mp.2008.113",

language = "English",

volume = "15",

pages = "647--656",

journal = "Molecular Psychiatry",

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Terracciano, A, Sanna, S, Uda, M, Deiana, B, Usala, G, Busonero, F, Maschio, A, Scally, M, Patriciu, N, Chen, W-M, Distel, MA, Slagboom, PE, Boomsma, DI, Villafuerte, S, Sliwerska, E, Burmeister, M, Amin, N, Janssens, ACJW, van Duijn, CM, Schlessinger, D, Abecasis, GR & Costa, PT 2010, 'Genome-wide association scan for five major dimensions of personality', Molecular Psychiatry, vol. 15, no. 6, pp. 647-656. https://doi.org/10.1038/mp.2008.113

TY - JOUR

T1 - Genome-wide association scan for five major dimensions of personality

AU - Terracciano, A.

AU - Sanna, S.

AU - Uda, M.

AU - Deiana, B.

AU - Usala, G.

AU - Busonero, F.

AU - Maschio, A.

AU - Scally, M.

AU - Patriciu, N.

AU - Chen, W.-M.

AU - Distel, M.A.

AU - Slagboom, P.E.

AU - Boomsma, D.I.

AU - Villafuerte, S.

AU - Sliwerska, E.

AU - Burmeister, M.

AU - Amin, N.

AU - Janssens, A.C.J.W.

AU - van Duijn, C.M.

AU - Schlessinger, D.

AU - Abecasis, G.R.

AU - Costa, P.T.

PY - 2010

Y1 - 2010

N2 - Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of 3972 individuals from a genetically isolated population within Sardinia, Italy. On the basis of the analyses of 362 129 single-nucleotide polymorphisms we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of neuroticism with SNAP25 (rs362584, P=5 × 10

AB - Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of 3972 individuals from a genetically isolated population within Sardinia, Italy. On the basis of the analyses of 362 129 single-nucleotide polymorphisms we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of neuroticism with SNAP25 (rs362584, P=5 × 10

U2 - 10.1038/mp.2008.113

DO - 10.1038/mp.2008.113

M3 - Article

SN - 1359-4184

VL - 15

SP - 647

EP - 656

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 6

ER -

Genome-wide association scan for five major dimensions of personality

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