Genome-wide association scan for five major dimensions of personality

A. Terracciano, S. Sanna, M. Uda, B. Deiana, G. Usala, F. Busonero, A. Maschio, M. Scally, N. Patriciu, W.-M. Chen, M.A. Distel, P.E. Slagboom, D.I. Boomsma, S. Villafuerte, E. Sliwerska, M. Burmeister, N. Amin, A.C.J.W. Janssens, C.M. van Duijn, D. SchlessingerG.R. Abecasis, P.T. Costa

Research output: Contribution to JournalArticleAcademicpeer-review


Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of 3972 individuals from a genetically isolated population within Sardinia, Italy. On the basis of the analyses of 362 129 single-nucleotide polymorphisms we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of neuroticism with SNAP25 (rs362584, P=5 × 10
Original languageEnglish
Pages (from-to)647-656
JournalMolecular Psychiatry
Issue number6
Publication statusPublished - 2010

Cohort Studies

  • Netherlands Twin Register (NTR)


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