TY - JOUR
T1 - Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations
AU - Lasky-Su, J.
AU - Neale, B.
AU - Franke, F.
AU - Anney, R.J.
AU - Zhou, K.
AU - Maller, J.B.
AU - Vasquez, A.A.
AU - Chen, W.
AU - Asherson, P.
AU - Buitelaar, J.
AU - Banaschewski, T.
AU - Ebstein, R.
AU - Gill, M.
AU - Miranda, A.
AU - Mulas, F.
AU - Oades, R.D.
AU - Roeyers, H.
AU - Rothenberger, A.
AU - Sergeant, J.A.
AU - Sonuga-Barke, E.J.S.
AU - Steinhausen, H.C.
AU - Taylor, E.
AU - Daly, M.J.
AU - Laird, N.
AU - Lange, C.
AU - Faraone, S.V.
PY - 2008
Y1 - 2008
N2 - Attention deficit hyperactivity disorder (ADHD) is a complex condition with environmental and genetic etiologies. Up to this point, research has identified genetic associations with candidate genes from known biological pathways. In order to identify novel ADHD susceptibility genes, 600,000 SNPs were genotyped in 958 ADHD pro-band-parent trios. After applying data cleaning procedures we examined 429,981 autosomal SNPs in 909 family trios. We generated six quantitative phenotypes from 18 ADHD symptoms to be used in genome-wide association analyses. With the PBAT screening algorithm, we identified 2 SNPs, rs6565113 and rs552655 that met the criteria for significance within a specified phenotype. These SNPs are located in intronic regions of genes CDH13 and GFOD1, respectively. CDH13 has been implicated previously in substance use disorders. We also evaluated the association of SNPs from a list of 37 ADHD candidate genes that was specified a priori. These findings, along with association P-values with a magnitude less than 10
AB - Attention deficit hyperactivity disorder (ADHD) is a complex condition with environmental and genetic etiologies. Up to this point, research has identified genetic associations with candidate genes from known biological pathways. In order to identify novel ADHD susceptibility genes, 600,000 SNPs were genotyped in 958 ADHD pro-band-parent trios. After applying data cleaning procedures we examined 429,981 autosomal SNPs in 909 family trios. We generated six quantitative phenotypes from 18 ADHD symptoms to be used in genome-wide association analyses. With the PBAT screening algorithm, we identified 2 SNPs, rs6565113 and rs552655 that met the criteria for significance within a specified phenotype. These SNPs are located in intronic regions of genes CDH13 and GFOD1, respectively. CDH13 has been implicated previously in substance use disorders. We also evaluated the association of SNPs from a list of 37 ADHD candidate genes that was specified a priori. These findings, along with association P-values with a magnitude less than 10
U2 - 10.1002/ajmg.b.30867
DO - 10.1002/ajmg.b.30867
M3 - Article
SN - 1552-4841
VL - 147B
SP - 1345
EP - 1354
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
IS - 8
ER -