Genome-wide association study confirms extant PD risk loci among the Dutch

J. Simon-Sanchez, J.J. van Hilten, B. van de Warrenburg, B. Post, H.W. Berendse, S. Arepalli, D.G. Hernandez, R.M.A. de Bie, D. Velseboer, H. Scheffer, B. Bloem, K.D. van Dijk, F. Rivadeneira, A. Hofman, A. G. Uitterlinden, P. Rizzu, Z. Bochdanovits, A.B. Singleton, P. Heutink

    Research output: Contribution to JournalArticleAcademicpeer-review


    In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P1.63 × 10
    Original languageEnglish
    Pages (from-to)655-661
    JournalEuropean Journal of Human Genetics
    Issue number6
    Publication statusPublished - 2011


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