Genome-wide association study confirms extant PD risk loci among the Dutch

J. Simon-Sanchez; J.J. van Hilten; B. van de Warrenburg; B. Post; H.W. Berendse; S. Arepalli; D.G. Hernandez; R.M.A. de Bie; D. Velseboer; H. Scheffer; B. Bloem; K.D. van Dijk; F. Rivadeneira; A. Hofman; A. G. Uitterlinden; P. Rizzu; Z. Bochdanovits; A.B. Singleton; P. Heutink

doi:10.1038/ejhg.2010.254

Genome-wide association study confirms extant PD risk loci among the Dutch

J. Simon-Sanchez, J.J. van Hilten, B. van de Warrenburg, B. Post, H.W. Berendse, S. Arepalli, D.G. Hernandez, R.M.A. de Bie, D. Velseboer, H. Scheffer, B. Bloem, K.D. van Dijk, F. Rivadeneira, A. Hofman, A. G. Uitterlinden, P. Rizzu, Z. Bochdanovits, A.B. Singleton, P. Heutink

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P1.63 × 10

Original language	English
Pages (from-to)	655-661
Journal	European Journal of Human Genetics
Volume	19
Issue number	6
DOIs	https://doi.org/10.1038/ejhg.2010.254
Publication status	Published - 2011

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Simon-Sanchez, J., van Hilten, J. J., van de Warrenburg, B., Post, B., Berendse, H. W., Arepalli, S., Hernandez, D. G., de Bie, R. M. A., Velseboer, D., Scheffer, H., Bloem, B., van Dijk, K. D., Rivadeneira, F., Hofman, A., Uitterlinden, A. G., Rizzu, P., Bochdanovits, Z., Singleton, A. B., & Heutink, P. (2011). Genome-wide association study confirms extant PD risk loci among the Dutch. European Journal of Human Genetics, 19(6), 655-661. https://doi.org/10.1038/ejhg.2010.254

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title = "Genome-wide association study confirms extant PD risk loci among the Dutch",

abstract = "In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P1.63 × 10",

author = "J. Simon-Sanchez and {van Hilten}, J.J. and {van de Warrenburg}, B. and B. Post and H.W. Berendse and S. Arepalli and D.G. Hernandez and {de Bie}, R.M.A. and D. Velseboer and H. Scheffer and B. Bloem and {van Dijk}, K.D. and F. Rivadeneira and A. Hofman and Uitterlinden, {A. G.} and P. Rizzu and Z. Bochdanovits and A.B. Singleton and P. Heutink",

year = "2011",

doi = "10.1038/ejhg.2010.254",

language = "English",

volume = "19",

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journal = "European Journal of Human Genetics",

issn = "1018-4813",

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Simon-Sanchez, J, van Hilten, JJ, van de Warrenburg, B, Post, B, Berendse, HW, Arepalli, S, Hernandez, DG, de Bie, RMA, Velseboer, D, Scheffer, H, Bloem, B, van Dijk, KD, Rivadeneira, F, Hofman, A, Uitterlinden, AG, Rizzu, P, Bochdanovits, Z, Singleton, AB & Heutink, P 2011, 'Genome-wide association study confirms extant PD risk loci among the Dutch', European Journal of Human Genetics, vol. 19, no. 6, pp. 655-661. https://doi.org/10.1038/ejhg.2010.254

TY - JOUR

T1 - Genome-wide association study confirms extant PD risk loci among the Dutch

AU - Simon-Sanchez, J.

AU - van Hilten, J.J.

AU - van de Warrenburg, B.

AU - Post, B.

AU - Berendse, H.W.

AU - Arepalli, S.

AU - Hernandez, D.G.

AU - de Bie, R.M.A.

AU - Velseboer, D.

AU - Scheffer, H.

AU - Bloem, B.

AU - van Dijk, K.D.

AU - Rivadeneira, F.

AU - Hofman, A.

AU - Uitterlinden, A. G.

AU - Rizzu, P.

AU - Bochdanovits, Z.

AU - Singleton, A.B.

AU - Heutink, P.

PY - 2011

Y1 - 2011

N2 - In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P1.63 × 10

AB - In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P1.63 × 10

U2 - 10.1038/ejhg.2010.254

DO - 10.1038/ejhg.2010.254

M3 - Article

VL - 19

SP - 655

EP - 661

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

IS - 6

ER -

Genome-wide association study confirms extant PD risk loci among the Dutch

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