Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

L. Oei; K. Estrada; E.L. Duncan; C. Christiansen; C.T. Liu; B.L. Langdahl; B. Obermayer-Pietsch; J.A. Riancho; R.L. Prince; N.M. van Schoor; E. McCloskey; Y.H. Hsu; E. Evangelou; E. Ntzani; D.M. Evans; N. Alonso; L.B. Husted; C. Valero; J.L. Hernandez; J.R. Lewis; S.K. Kaptoge; K. Zhu; L.A. Cupples; C. Medina-Gomez; L. Vandenput; G.S. Kim; S.H. Lee; M.C. Castano-Betancourt; E.H.G. Oei; J. Martinez; A. Daroszewska; M. van der Klift; D. Mellstrom; L Herrera; M.K. Karlsson; A. Hofman; O. Ljunggren; H.A.P. Pols; L. Stolk; J.B.J. van Meurs; J.P.A. Ioannidis; M.C. Zillikens; P.T.A.M. Lips; D. Karasik; A. G. Uitterlinden; U. Styrkarsdottir; M. A. Brown; J.M. Koh; J.B. Richards; J. Reeve; C. Ohlsson; S.H. Ralston; D.P. Kiel; F. Rivadeneira

doi:10.1016/j.bone.2013.10.015

Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

L. Oei, K. Estrada, E.L. Duncan, C. Christiansen, C.T. Liu, B.L. Langdahl, B. Obermayer-Pietsch, J.A. Riancho, R.L. Prince, N.M. van Schoor, E. McCloskey, Y.H. Hsu, E. Evangelou, E. Ntzani, D.M. Evans, N. Alonso, L.B. Husted, C. Valero, J.L. Hernandez, J.R. LewisS.K. Kaptoge, K. Zhu, L.A. Cupples, C. Medina-Gomez, L. Vandenput, G.S. Kim, S.H. Lee, M.C. Castano-Betancourt, E.H.G. Oei, J. Martinez, A. Daroszewska, M. van der Klift, D. Mellstrom, L Herrera, M.K. Karlsson, A. Hofman, O. Ljunggren, H.A.P. Pols, L. Stolk, J.B.J. van Meurs, J.P.A. Ioannidis, M.C. Zillikens, P.T.A.M. Lips, D. Karasik, A. G. Uitterlinden, U. Styrkarsdottir, M. A. Brown, J.M. Koh, J.B. Richards, J. Reeve, C. Ohlsson, S.H. Ralston, D.P. Kiel, F. Rivadeneira

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Abstract

Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p<5×10

Original language	English
Pages (from-to)	20-27
Journal	Bone
Volume	59
DOIs	https://doi.org/10.1016/j.bone.2013.10.015
Publication status	Published - 2014

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Oei, L., Estrada, K., Duncan, E. L., Christiansen, C., Liu, C. T., Langdahl, B. L., Obermayer-Pietsch, B., Riancho, J. A., Prince, R. L., van Schoor, N. M., McCloskey, E., Hsu, Y. H., Evangelou, E., Ntzani, E., Evans, D. M., Alonso, N., Husted, L. B., Valero, C., Hernandez, J. L., ... Rivadeneira, F. (2014). Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. Bone, 59, 20-27. https://doi.org/10.1016/j.bone.2013.10.015

@article{2c0aae1e0df74704a089b63cc9342cd6,

title = "Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus",

abstract = "Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p<5×10",

author = "L. Oei and K. Estrada and E.L. Duncan and C. Christiansen and C.T. Liu and B.L. Langdahl and B. Obermayer-Pietsch and J.A. Riancho and R.L. Prince and {van Schoor}, N.M. and E. McCloskey and Y.H. Hsu and E. Evangelou and E. Ntzani and D.M. Evans and N. Alonso and L.B. Husted and C. Valero and J.L. Hernandez and J.R. Lewis and S.K. Kaptoge and K. Zhu and L.A. Cupples and C. Medina-Gomez and L. Vandenput and G.S. Kim and S.H. Lee and M.C. Castano-Betancourt and E.H.G. Oei and J. Martinez and A. Daroszewska and {van der Klift}, M. and D. Mellstrom and L Herrera and M.K. Karlsson and A. Hofman and O. Ljunggren and H.A.P. Pols and L. Stolk and {van Meurs}, J.B.J. and J.P.A. Ioannidis and M.C. Zillikens and P.T.A.M. Lips and D. Karasik and Uitterlinden, {A. G.} and U. Styrkarsdottir and Brown, {M. A.} and J.M. Koh and J.B. Richards and J. Reeve and C. Ohlsson and S.H. Ralston and D.P. Kiel and F. Rivadeneira",

year = "2014",

doi = "10.1016/j.bone.2013.10.015",

language = "English",

volume = "59",

pages = "20--27",

journal = "Bone",

issn = "8756-3282",

publisher = "Elsevier Inc.",

}

Oei, L, Estrada, K, Duncan, EL, Christiansen, C, Liu, CT, Langdahl, BL, Obermayer-Pietsch, B, Riancho, JA, Prince, RL, van Schoor, NM, McCloskey, E, Hsu, YH, Evangelou, E, Ntzani, E, Evans, DM, Alonso, N, Husted, LB, Valero, C, Hernandez, JL, Lewis, JR, Kaptoge, SK, Zhu, K, Cupples, LA, Medina-Gomez, C, Vandenput, L, Kim, GS, Lee, SH, Castano-Betancourt, MC, Oei, EHG, Martinez, J, Daroszewska, A, van der Klift, M, Mellstrom, D, Herrera, L, Karlsson, MK, Hofman, A, Ljunggren, O, Pols, HAP, Stolk, L, van Meurs, JBJ, Ioannidis, JPA, Zillikens, MC, Lips, PTAM, Karasik, D, Uitterlinden, AG, Styrkarsdottir, U, Brown, MA, Koh, JM, Richards, JB, Reeve, J, Ohlsson, C, Ralston, SH, Kiel, DP & Rivadeneira, F 2014, 'Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus', Bone, vol. 59, pp. 20-27. https://doi.org/10.1016/j.bone.2013.10.015

TY - JOUR

T1 - Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

AU - Oei, L.

AU - Estrada, K.

AU - Duncan, E.L.

AU - Christiansen, C.

AU - Liu, C.T.

AU - Langdahl, B.L.

AU - Obermayer-Pietsch, B.

AU - Riancho, J.A.

AU - Prince, R.L.

AU - van Schoor, N.M.

AU - McCloskey, E.

AU - Hsu, Y.H.

AU - Evangelou, E.

AU - Ntzani, E.

AU - Evans, D.M.

AU - Alonso, N.

AU - Husted, L.B.

AU - Valero, C.

AU - Hernandez, J.L.

AU - Lewis, J.R.

AU - Kaptoge, S.K.

AU - Zhu, K.

AU - Cupples, L.A.

AU - Medina-Gomez, C.

AU - Vandenput, L.

AU - Kim, G.S.

AU - Lee, S.H.

AU - Castano-Betancourt, M.C.

AU - Oei, E.H.G.

AU - Martinez, J.

AU - Daroszewska, A.

AU - van der Klift, M.

AU - Mellstrom, D.

AU - Herrera, L

AU - Karlsson, M.K.

AU - Hofman, A.

AU - Ljunggren, O.

AU - Pols, H.A.P.

AU - Stolk, L.

AU - van Meurs, J.B.J.

AU - Ioannidis, J.P.A.

AU - Zillikens, M.C.

AU - Lips, P.T.A.M.

AU - Karasik, D.

AU - Uitterlinden, A. G.

AU - Styrkarsdottir, U.

AU - Brown, M. A.

AU - Koh, J.M.

AU - Richards, J.B.

AU - Reeve, J.

AU - Ohlsson, C.

AU - Ralston, S.H.

AU - Kiel, D.P.

AU - Rivadeneira, F.

PY - 2014

Y1 - 2014

N2 - Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p<5×10

AB - Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p<5×10

U2 - 10.1016/j.bone.2013.10.015

DO - 10.1016/j.bone.2013.10.015

M3 - Article

SN - 8756-3282

VL - 59

SP - 20

EP - 27

JO - Bone

JF - Bone

ER -

Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

Abstract

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