Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

M. Beekman; C. Nederstigt; H.E.D. Suchiman; D. Kremer; R. van der Breggen; N. Lakenberg; W.G. Alemayehu; A.J. de Craen; R.G.J. Westendorp; D.I. Boomsma; E.J.C. de Geus; J.J. Houwing-Duistermaat; B.T. Heijmans; P.E. Slagboom

doi:10.1073/pnas.1003540107

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

M. Beekman
, C. Nederstigt
, H.E.D. Suchiman
, D. Kremer
, R. van der Breggen
, N. Lakenberg
, W.G. Alemayehu
, A.J. de Craen
, R.G.J. Westendorp
, D.I. Boomsma
, E.J.C. de Geus
, J.J. Houwing-Duistermaat
, B.T. Heijmans
, P.E. Slagboom

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.

Original language	English
Pages (from-to)	18046-18049
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	42
DOIs	https://doi.org/10.1073/pnas.1003540107
Publication status	Published - 2010

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10.1073/pnas.1003540107

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Beekman, M., Nederstigt, C., Suchiman, H. E. D., Kremer, D., van der Breggen, R., Lakenberg, N., Alemayehu, W. G., de Craen, A. J., Westendorp, R. G. J., Boomsma, D. I., de Geus, E. J. C., Houwing-Duistermaat, J. J., Heijmans, B. T., & Slagboom, P. E. (2010). Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18046-18049. https://doi.org/10.1073/pnas.1003540107

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abstract = "A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.",

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Beekman, M, Nederstigt, C, Suchiman, HED, Kremer, D, van der Breggen, R, Lakenberg, N, Alemayehu, WG, de Craen, AJ, Westendorp, RGJ, Boomsma, DI , de Geus, EJC, Houwing-Duistermaat, JJ, Heijmans, BT & Slagboom, PE 2010, 'Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 42, pp. 18046-18049. https://doi.org/10.1073/pnas.1003540107

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T1 - Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

AU - Beekman, M.

AU - Nederstigt, C.

AU - Suchiman, H.E.D.

AU - Kremer, D.

AU - van der Breggen, R.

AU - Lakenberg, N.

AU - Alemayehu, W.G.

AU - de Craen, A.J.

AU - Westendorp, R.G.J.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

AU - Houwing-Duistermaat, J.J.

AU - Heijmans, B.T.

AU - Slagboom, P.E.

PY - 2010

Y1 - 2010

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AB - A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.

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DO - 10.1073/pnas.1003540107

M3 - Article

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VL - 107

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EP - 18049

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 42

ER -

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

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