Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

J.C. Chambers, W. Zhang, J. Sehmi, X. Li, M.N. Wass, P. van der Harst, H. Holm, S. Sanna, M. Kavousi, S.E. Baumeister, J.J. Hottenga, E.K. Speliotes, E.J.C. de Geus, N.G. Martin, G.W. Montgomery, B.W.J.H. Penninx, I. Prokopenko, T.D. Spector, A.G. Uitterlinden, G. WillemsenG.R. Abecasis, D.I. Boomsma, C.M. van Duijn, H. Snieder, J.B. Whitfield, J.C.M. Witteman, C.S. Fox, M. Ala-Korpela, K. Stefansson, P. Vollenweider, H. Völzke, E.E. Schadt, J. Scott, M.R. Jarvelin, P. Elliot, J.S. Kooner

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10
Original languageEnglish
Pages (from-to)1131-1140
JournalNature Genetics
Volume43
Issue number11
DOIs
Publication statusPublished - 2011

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Chambers, J. C., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., ... Kooner, J. S. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-1140. https://doi.org/10.1038/ng.970