Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

J.C. Chambers; W. Zhang; J. Sehmi; X. Li; M.N. Wass; P. van der Harst; H. Holm; S. Sanna; M. Kavousi; S.E. Baumeister; J.J. Hottenga; E.K. Speliotes; E.J.C. de Geus; N.G. Martin; G.W. Montgomery; B.W.J.H. Penninx; I. Prokopenko; T.D. Spector; A.G. Uitterlinden; G. Willemsen; G.R. Abecasis; D.I. Boomsma; C.M. van Duijn; H. Snieder; J.B. Whitfield; J.C.M. Witteman; C.S. Fox; M. Ala-Korpela; K. Stefansson; P. Vollenweider; H. Völzke; E.E. Schadt; J. Scott; M.R. Jarvelin; P. Elliot; J.S. Kooner

doi:10.1038/ng.970

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

J.C. Chambers
, W. Zhang
, J. Sehmi
, X. Li
, M.N. Wass
, P. van der Harst
, H. Holm
, S. Sanna
, M. Kavousi
, S.E. Baumeister
, J.J. Hottenga
, E.K. Speliotes
, E.J.C. de Geus
, N.G. Martin
, G.W. Montgomery
, B.W.J.H. Penninx
, I. Prokopenko
, T.D. Spector
, A.G. Uitterlinden
, G. Willemsen

G.R. Abecasis, D.I. Boomsma, C.M. van Duijn, H. Snieder, J.B. Whitfield, J.C.M. Witteman, C.S. Fox, M. Ala-Korpela, K. Stefansson, P. Vollenweider, H. Völzke, E.E. Schadt, J. Scott, M.R. Jarvelin, P. Elliot, J.S. Kooner

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10

Original language	English
Pages (from-to)	1131-1140
Journal	Nature Genetics
Volume	43
Issue number	11
DOIs	https://doi.org/10.1038/ng.970
Publication status	Published - 2011

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SDG 3 Good Health and Well-being

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10.1038/ng.970

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Chambers, J. C., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Holm, H., Sanna, S., Kavousi, M., Baumeister, S. E., Hottenga, J. J., Speliotes, E. K., de Geus, E. J. C., Martin, N. G., Montgomery, G. W., Penninx, B. W. J. H., Prokopenko, I., Spector, T. D., Uitterlinden, A. G., ... Kooner, J. S. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-1140. https://doi.org/10.1038/ng.970

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title = "Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma",

abstract = "Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10",

author = "J.C. Chambers and W. Zhang and J. Sehmi and X. Li and M.N. Wass and \{van der Harst\}, P. and H. Holm and S. Sanna and M. Kavousi and S.E. Baumeister and J.J. Hottenga and E.K. Speliotes and \{de Geus\}, E.J.C. and N.G. Martin and G.W. Montgomery and B.W.J.H. Penninx and I. Prokopenko and T.D. Spector and A.G. Uitterlinden and G. Willemsen and G.R. Abecasis and D.I. Boomsma and \{van Duijn\}, C.M. and H. Snieder and J.B. Whitfield and J.C.M. Witteman and C.S. Fox and M. Ala-Korpela and K. Stefansson and P. Vollenweider and H. V{\"o}lzke and E.E. Schadt and J. Scott and M.R. Jarvelin and P. Elliot and J.S. Kooner",

year = "2011",

doi = "10.1038/ng.970",

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volume = "43",

pages = "1131--1140",

journal = "Nature Genetics",

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Chambers, JC, Zhang, W, Sehmi, J, Li, X, Wass, MN, van der Harst, P, Holm, H, Sanna, S, Kavousi, M, Baumeister, SE, Hottenga, JJ, Speliotes, EK, de Geus, EJC, Martin, NG, Montgomery, GW, Penninx, BWJH, Prokopenko, I, Spector, TD, Uitterlinden, AG, Willemsen, G, Abecasis, GR, Boomsma, DI, van Duijn, CM, Snieder, H, Whitfield, JB, Witteman, JCM, Fox, CS, Ala-Korpela, M, Stefansson, K, Vollenweider, P, Völzke, H, Schadt, EE, Scott, J, Jarvelin, MR, Elliot, P & Kooner, JS 2011, 'Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma', Nature Genetics, vol. 43, no. 11, pp. 1131-1140. https://doi.org/10.1038/ng.970

TY - JOUR

T1 - Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

AU - Chambers, J.C.

AU - Zhang, W.

AU - Sehmi, J.

AU - Li, X.

AU - Wass, M.N.

AU - van der Harst, P.

AU - Holm, H.

AU - Sanna, S.

AU - Kavousi, M.

AU - Baumeister, S.E.

AU - Hottenga, J.J.

AU - Speliotes, E.K.

AU - de Geus, E.J.C.

AU - Martin, N.G.

AU - Montgomery, G.W.

AU - Penninx, B.W.J.H.

AU - Prokopenko, I.

AU - Spector, T.D.

AU - Uitterlinden, A.G.

AU - Willemsen, G.

AU - Abecasis, G.R.

AU - Boomsma, D.I.

AU - van Duijn, C.M.

AU - Snieder, H.

AU - Whitfield, J.B.

AU - Witteman, J.C.M.

AU - Fox, C.S.

AU - Ala-Korpela, M.

AU - Stefansson, K.

AU - Vollenweider, P.

AU - Völzke, H.

AU - Schadt, E.E.

AU - Scott, J.

AU - Jarvelin, M.R.

AU - Elliot, P.

AU - Kooner, J.S.

PY - 2011

Y1 - 2011

N2 - Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10

AB - Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10

U2 - 10.1038/ng.970

DO - 10.1038/ng.970

M3 - Article

SN - 1061-4036

VL - 43

SP - 1131

EP - 1140

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Abstract

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