Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

L.V. Wain; G.C. Verwoert; P.F. O'Reilly; G. Shi; T. Johnson; A.D. Johnson; M. Bochud; K.M. Rice; P. Henneman; A.V. Smith; G.B. Ehret; N. Amin; M.G. Larson; V. Mooser; D. Hadley; M. Dörr; J.C. Bis; T. Aspelund; T. Esko; A.C. Janssens; J.H. Zhao; S. Heath; M. Laan; J. Fu; G. Pistis; J. Luan; P. Arora; J.J. Hottenga; F. Rivadeneira; E.J. Sijbrands; A.G. Uitterlinden; N. Soranzo; E.J.C. de Geus; G. Willemsen; D.I. Boomsma; T.D. Spector; H. Snieder; B.A. Oostra; A. Metspalu; L. Launer; R. Rettig; D.P. Strachan; J.S. Beckmann; J.C. Witteman; J. Erdmann; K.W. van Dijk; E. Boerwinkle; M. Boehnke; P.M. Ridker; M.R. Jarvelin; A. Chakravarti; G.R. Abecasis; V. Gudnason; C. Newton-Cheh; D. Levy; P.B. Munroe; B.M. Psaty; M.J. Caulfield; D.C. Rao; M.D. Tobin; P. Elliott; C.M. van Duijn

doi:10.1038/ng.922

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

L.V. Wain, G.C. Verwoert, P.F. O'Reilly, G. Shi, T. Johnson, A.D. Johnson, M. Bochud, K.M. Rice, P. Henneman, A.V. Smith, G.B. Ehret, N. Amin, M.G. Larson, V. Mooser, D. Hadley, M. Dörr, J.C. Bis, T. Aspelund, T. Esko, A.C. JanssensJ.H. Zhao, S. Heath, M. Laan, J. Fu, G. Pistis, J. Luan, P. Arora, J.J. Hottenga, F. Rivadeneira, E.J. Sijbrands, A.G. Uitterlinden, N. Soranzo, E.J.C. de Geus, G. Willemsen, D.I. Boomsma, T.D. Spector, H. Snieder, B.A. Oostra, A. Metspalu, L. Launer, R. Rettig, D.P. Strachan, J.S. Beckmann, J.C. Witteman, J. Erdmann, K.W. van Dijk, E. Boerwinkle, M. Boehnke, P.M. Ridker, M.R. Jarvelin, A. Chakravarti, G.R. Abecasis, V. Gudnason, C. Newton-Cheh, D. Levy, P.B. Munroe, B.M. Psaty, M.J. Caulfield, D.C. Rao, M.D. Tobin, P. Elliott, C.M. van Duijn

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10 -8 to P = 2.3 × 10 -13) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP. © 2011 Nature America, Inc. All rights reserved.

Original language	English
Pages (from-to)	1005-1012
Journal	Nature Genetics
Volume	43
Issue number	10
DOIs	https://doi.org/10.1038/ng.922
Publication status	Published - 2011

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Wain, L. V., Verwoert, G. C., O'Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., Henneman, P., Smith, A. V., Ehret, G. B., Amin, N., Larson, M. G., Mooser, V., Hadley, D., Dörr, M., Bis, J. C., Aspelund, T., Esko, T., ... van Duijn, C. M. (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics, 43(10), 1005-1012. https://doi.org/10.1038/ng.922

@article{648317f5d11f4515a9b7eea1cad4c0e2,

title = "Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure",

abstract = "Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10 -8 to P = 2.3 × 10 -13) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP. {\textcopyright} 2011 Nature America, Inc. All rights reserved.",

author = "L.V. Wain and G.C. Verwoert and P.F. O'Reilly and G. Shi and T. Johnson and A.D. Johnson and M. Bochud and K.M. Rice and P. Henneman and A.V. Smith and G.B. Ehret and N. Amin and M.G. Larson and V. Mooser and D. Hadley and M. D{\"o}rr and J.C. Bis and T. Aspelund and T. Esko and A.C. Janssens and J.H. Zhao and S. Heath and M. Laan and J. Fu and G. Pistis and J. Luan and P. Arora and J.J. Hottenga and F. Rivadeneira and E.J. Sijbrands and A.G. Uitterlinden and N. Soranzo and {de Geus}, E.J.C. and G. Willemsen and D.I. Boomsma and T.D. Spector and H. Snieder and B.A. Oostra and A. Metspalu and L. Launer and R. Rettig and D.P. Strachan and J.S. Beckmann and J.C. Witteman and J. Erdmann and {van Dijk}, K.W. and E. Boerwinkle and M. Boehnke and P.M. Ridker and M.R. Jarvelin and A. Chakravarti and G.R. Abecasis and V. Gudnason and C. Newton-Cheh and D. Levy and P.B. Munroe and B.M. Psaty and M.J. Caulfield and D.C. Rao and M.D. Tobin and P. Elliott and {van Duijn}, C.M.",

year = "2011",

doi = "10.1038/ng.922",

language = "English",

volume = "43",

pages = "1005--1012",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

Wain, LV, Verwoert, GC, O'Reilly, PF, Shi, G, Johnson, T, Johnson, AD, Bochud, M, Rice, KM, Henneman, P, Smith, AV, Ehret, GB, Amin, N, Larson, MG, Mooser, V, Hadley, D, Dörr, M, Bis, JC, Aspelund, T, Esko, T, Janssens, AC, Zhao, JH, Heath, S, Laan, M, Fu, J, Pistis, G, Luan, J, Arora, P, Hottenga, JJ, Rivadeneira, F, Sijbrands, EJ, Uitterlinden, AG, Soranzo, N, de Geus, EJC , Willemsen, G , Boomsma, DI, Spector, TD, Snieder, H, Oostra, BA, Metspalu, A, Launer, L, Rettig, R, Strachan, DP, Beckmann, JS, Witteman, JC, Erdmann, J, van Dijk, KW, Boerwinkle, E, Boehnke, M, Ridker, PM, Jarvelin, MR, Chakravarti, A, Abecasis, GR, Gudnason, V, Newton-Cheh, C, Levy, D, Munroe, PB, Psaty, BM, Caulfield, MJ, Rao, DC, Tobin, MD, Elliott, P & van Duijn, CM 2011, 'Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure', Nature Genetics, vol. 43, no. 10, pp. 1005-1012. https://doi.org/10.1038/ng.922

TY - JOUR

T1 - Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

AU - Wain, L.V.

AU - Verwoert, G.C.

AU - O'Reilly, P.F.

AU - Shi, G.

AU - Johnson, T.

AU - Johnson, A.D.

AU - Bochud, M.

AU - Rice, K.M.

AU - Henneman, P.

AU - Smith, A.V.

AU - Ehret, G.B.

AU - Amin, N.

AU - Larson, M.G.

AU - Mooser, V.

AU - Hadley, D.

AU - Dörr, M.

AU - Bis, J.C.

AU - Aspelund, T.

AU - Esko, T.

AU - Janssens, A.C.

AU - Zhao, J.H.

AU - Heath, S.

AU - Laan, M.

AU - Fu, J.

AU - Pistis, G.

AU - Luan, J.

AU - Arora, P.

AU - Hottenga, J.J.

AU - Rivadeneira, F.

AU - Sijbrands, E.J.

AU - Uitterlinden, A.G.

AU - Soranzo, N.

AU - de Geus, E.J.C.

AU - Willemsen, G.

AU - Boomsma, D.I.

AU - Spector, T.D.

AU - Snieder, H.

AU - Oostra, B.A.

AU - Metspalu, A.

AU - Launer, L.

AU - Rettig, R.

AU - Strachan, D.P.

AU - Beckmann, J.S.

AU - Witteman, J.C.

AU - Erdmann, J.

AU - van Dijk, K.W.

AU - Boerwinkle, E.

AU - Boehnke, M.

AU - Ridker, P.M.

AU - Jarvelin, M.R.

AU - Chakravarti, A.

AU - Abecasis, G.R.

AU - Gudnason, V.

AU - Newton-Cheh, C.

AU - Levy, D.

AU - Munroe, P.B.

AU - Psaty, B.M.

AU - Caulfield, M.J.

AU - Rao, D.C.

AU - Tobin, M.D.

AU - Elliott, P.

AU - van Duijn, C.M.

PY - 2011

Y1 - 2011

N2 - Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10 -8 to P = 2.3 × 10 -13) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP. © 2011 Nature America, Inc. All rights reserved.

AB - Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10 -8 to P = 2.3 × 10 -13) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP. © 2011 Nature America, Inc. All rights reserved.

U2 - 10.1038/ng.922

DO - 10.1038/ng.922

M3 - Article

SN - 1061-4036

VL - 43

SP - 1005

EP - 1012

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

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