Genome-wide association study of obsessive-compulsive disorder

S.E. Stewart; D. Yu; J.M. Scharf; B.M. Neale; J.A. Fagerness; C.A. Mathews; P.D. Arnold; P.D. Evans; E.R. Gamazon; L.K. Davis; L. Osiecki; L. McGrath; S. Haddad; J. Crane; D. Hezel; C. Illmann; C. Mayerfeld; A.I. Konkashbaev; C. Liu; A. Pluzhnikov; A. Tikhomirov; C.K. Edlund; S.L. Rauch; R. Moessner; P. Falkai; W. Maier; S. Ruhrmann; H.J. Grabe; L. Lennertz; M. Wagner; L. Bellodi; M.C. Cavallini; M.A. Richter; E.H. Cook; J.L. Kennedy; D. Rosenberg; D.J. Stein; S.M. Hemmings; C. Lochner; A. Azzam; D.A. Chavira; E. Fournier; H. Garrido; B. Sheppard; P. Umaña; D.L. Murphy; J.R. Wendland; J. Veenstra-Vanderweele; D. Denys; R. Blom; D. Deforce; F. van Nieuwerburgh; H.G. Westenberg; S. Walitza; K. Egberts; T. Renner; E.C. Miguel; C. Cappi; A.G. Hounie; M. Conceição do Rosário; A.S. Sampaio; H. Vallada; H. Nicolini; N. Lanzagorta; B. Camarena; R. Delorme; M. Leboyer; C.N. Pato; M.T. Pato; E. Voyiaziakis; P. Heutink; D.C. Cath; D. Posthuma; J.H. Smit; J. Samuels; O.J. Bienvenu; B. Cullen; A.J. Fyer; M.A. Grados; B.D. Greenberg; J.T. McCracken; M.A. Riddle; Y. Wang; V. Coric; J.F. Leckman; M. Bloch; C. Pittenger; V. Eapen; D.W. Black; R.A. Ophoff; E. Strengman; D. Cusi; M. Turiel; F. Frau; F. Macciardi; J.R. Gibbs; M.R. Cookson; A. Singleton; J. Hardy; A.T. Crenshaw; M.A. Parkin; D.B. Mirel; D.V. Conti; S. Purcell; G. Nestadt; G.L. Hanna; M.A. Jenike; J.A. Knowles; N. Cox; D.L. Pauls

doi:10.1038/mp.2012.85

Genome-wide association study of obsessive-compulsive disorder

S.E. Stewart
, D. Yu
, J.M. Scharf
, B.M. Neale
, J.A. Fagerness
, C.A. Mathews
, P.D. Arnold
, P.D. Evans
, E.R. Gamazon
, L.K. Davis
, L. Osiecki
, L. McGrath
, S. Haddad
, J. Crane
, D. Hezel
, C. Illmann
, C. Mayerfeld
, A.I. Konkashbaev
, C. Liu
, A. Pluzhnikov

A. Tikhomirov, C.K. Edlund, S.L. Rauch, R. Moessner, P. Falkai, W. Maier, S. Ruhrmann, H.J. Grabe, L. Lennertz, M. Wagner, L. Bellodi, M.C. Cavallini, M.A. Richter, E.H. Cook, J.L. Kennedy, D. Rosenberg, D.J. Stein, S.M. Hemmings, C. Lochner, A. Azzam, D.A. Chavira, E. Fournier, H. Garrido, B. Sheppard, P. Umaña, D.L. Murphy, J.R. Wendland, J. Veenstra-Vanderweele, D. Denys, R. Blom, D. Deforce, F. van Nieuwerburgh, H.G. Westenberg, S. Walitza, K. Egberts, T. Renner, E.C. Miguel, C. Cappi, A.G. Hounie, M. Conceição do Rosário, A.S. Sampaio, H. Vallada, H. Nicolini, N. Lanzagorta, B. Camarena, R. Delorme, M. Leboyer, C.N. Pato, M.T. Pato, E. Voyiaziakis, P. Heutink, D.C. Cath, D. Posthuma, J.H. Smit, J. Samuels, O.J. Bienvenu, B. Cullen, A.J. Fyer, M.A. Grados, B.D. Greenberg, J.T. McCracken, M.A. Riddle, Y. Wang, V. Coric, J.F. Leckman, M. Bloch, C. Pittenger, V. Eapen, D.W. Black, R.A. Ophoff, E. Strengman, D. Cusi, M. Turiel, F. Frau, F. Macciardi, J.R. Gibbs, M.R. Cookson, A. Singleton, J. Hardy, A.T. Crenshaw, M.A. Parkin, D.B. Mirel, D.V. Conti, S. Purcell, G. Nestadt, G.L. Hanna, M.A. Jenike, J.A. Knowles, N. Cox, D.L. Pauls

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469 410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10

Original language	English
Pages (from-to)	788-798
Journal	Molecular Psychiatry
Volume	18
Issue number	7
Early online date	14 Aug 2012
DOIs	https://doi.org/10.1038/mp.2012.85
Publication status	Published - 2013

Bibliographical note

North American Brain Expression Consortium; UK Brain Expression Database

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 17 Partnerships for the Goals

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10.1038/mp.2012.85

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Stewart, S. E., Yu, D., Scharf, J. M., Neale, B. M., Fagerness, J. A., Mathews, C. A., Arnold, P. D., Evans, P. D., Gamazon, E. R., Davis, L. K., Osiecki, L., McGrath, L., Haddad, S., Crane, J., Hezel, D., Illmann, C., Mayerfeld, C., Konkashbaev, A. I., Liu, C., ... Pauls, D. L. (2013). Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry, 18(7), 788-798. https://doi.org/10.1038/mp.2012.85

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abstract = "Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469 410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10",

author = "S.E. Stewart and D. Yu and J.M. Scharf and B.M. Neale and J.A. Fagerness and C.A. Mathews and P.D. Arnold and P.D. Evans and E.R. Gamazon and L.K. Davis and L. Osiecki and L. McGrath and S. Haddad and J. Crane and D. Hezel and C. Illmann and C. Mayerfeld and A.I. Konkashbaev and C. Liu and A. Pluzhnikov and A. Tikhomirov and C.K. Edlund and S.L. Rauch and R. Moessner and P. Falkai and W. Maier and S. Ruhrmann and H.J. Grabe and L. Lennertz and M. Wagner and L. Bellodi and M.C. Cavallini and M.A. Richter and E.H. Cook and J.L. Kennedy and D. Rosenberg and D.J. Stein and S.M. Hemmings and C. Lochner and A. Azzam and D.A. Chavira and E. Fournier and H. Garrido and B. Sheppard and P. Uma{\~n}a and D.L. Murphy and J.R. Wendland and J. Veenstra-Vanderweele and D. Denys and R. Blom and D. Deforce and \{van Nieuwerburgh\}, F. and H.G. Westenberg and S. Walitza and K. Egberts and T. Renner and E.C. Miguel and C. Cappi and A.G. Hounie and \{Concei{\c c}{\~a}o do Ros{\'a}rio\}, M. and A.S. Sampaio and H. Vallada and H. Nicolini and N. Lanzagorta and B. Camarena and R. Delorme and M. Leboyer and C.N. Pato and M.T. Pato and E. Voyiaziakis and P. Heutink and D.C. Cath and D. Posthuma and J.H. Smit and J. Samuels and O.J. Bienvenu and B. Cullen and A.J. Fyer and M.A. Grados and B.D. Greenberg and J.T. McCracken and M.A. Riddle and Y. Wang and V. Coric and J.F. Leckman and M. Bloch and C. Pittenger and V. Eapen and D.W. Black and R.A. Ophoff and E. Strengman and D. Cusi and M. Turiel and F. Frau and F. Macciardi and J.R. Gibbs and M.R. Cookson and A. Singleton and J. Hardy and A.T. Crenshaw and M.A. Parkin and D.B. Mirel and D.V. Conti and S. Purcell and G. Nestadt and G.L. Hanna and M.A. Jenike and J.A. Knowles and N. Cox and D.L. Pauls",

note = "North American Brain Expression Consortium; UK Brain Expression Database",

year = "2013",

doi = "10.1038/mp.2012.85",

language = "English",

volume = "18",

pages = "788--798",

journal = "Molecular Psychiatry",

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Stewart, SE, Yu, D, Scharf, JM, Neale, BM, Fagerness, JA, Mathews, CA, Arnold, PD, Evans, PD, Gamazon, ER, Davis, LK, Osiecki, L, McGrath, L, Haddad, S, Crane, J, Hezel, D, Illmann, C, Mayerfeld, C, Konkashbaev, AI, Liu, C, Pluzhnikov, A, Tikhomirov, A, Edlund, CK, Rauch, SL, Moessner, R, Falkai, P, Maier, W, Ruhrmann, S, Grabe, HJ, Lennertz, L, Wagner, M, Bellodi, L, Cavallini, MC, Richter, MA, Cook, EH, Kennedy, JL, Rosenberg, D, Stein, DJ, Hemmings, SM, Lochner, C, Azzam, A, Chavira, DA, Fournier, E, Garrido, H, Sheppard, B, Umaña, P, Murphy, DL, Wendland, JR, Veenstra-Vanderweele, J, Denys, D, Blom, R, Deforce, D, van Nieuwerburgh, F, Westenberg, HG, Walitza, S, Egberts, K, Renner, T, Miguel, EC, Cappi, C, Hounie, AG, Conceição do Rosário, M, Sampaio, AS, Vallada, H, Nicolini, H, Lanzagorta, N, Camarena, B, Delorme, R, Leboyer, M, Pato, CN, Pato, MT, Voyiaziakis, E, Heutink, P, Cath, DC, Posthuma, D, Smit, JH, Samuels, J, Bienvenu, OJ, Cullen, B, Fyer, AJ, Grados, MA, Greenberg, BD, McCracken, JT, Riddle, MA, Wang, Y, Coric, V, Leckman, JF, Bloch, M, Pittenger, C, Eapen, V, Black, DW, Ophoff, RA, Strengman, E, Cusi, D, Turiel, M, Frau, F, Macciardi, F, Gibbs, JR, Cookson, MR, Singleton, A, Hardy, J, Crenshaw, AT, Parkin, MA, Mirel, DB, Conti, DV, Purcell, S, Nestadt, G, Hanna, GL, Jenike, MA, Knowles, JA, Cox, N & Pauls, DL 2013, 'Genome-wide association study of obsessive-compulsive disorder', Molecular Psychiatry, vol. 18, no. 7, pp. 788-798. https://doi.org/10.1038/mp.2012.85

TY - JOUR

T1 - Genome-wide association study of obsessive-compulsive disorder

AU - Stewart, S.E.

AU - Yu, D.

AU - Scharf, J.M.

AU - Neale, B.M.

AU - Fagerness, J.A.

AU - Mathews, C.A.

AU - Arnold, P.D.

AU - Evans, P.D.

AU - Gamazon, E.R.

AU - Davis, L.K.

AU - Osiecki, L.

AU - McGrath, L.

AU - Haddad, S.

AU - Crane, J.

AU - Hezel, D.

AU - Illmann, C.

AU - Mayerfeld, C.

AU - Konkashbaev, A.I.

AU - Liu, C.

AU - Pluzhnikov, A.

AU - Tikhomirov, A.

AU - Edlund, C.K.

AU - Rauch, S.L.

AU - Moessner, R.

AU - Falkai, P.

AU - Maier, W.

AU - Ruhrmann, S.

AU - Grabe, H.J.

AU - Lennertz, L.

AU - Wagner, M.

AU - Bellodi, L.

AU - Cavallini, M.C.

AU - Richter, M.A.

AU - Cook, E.H.

AU - Kennedy, J.L.

AU - Rosenberg, D.

AU - Stein, D.J.

AU - Hemmings, S.M.

AU - Lochner, C.

AU - Azzam, A.

AU - Chavira, D.A.

AU - Fournier, E.

AU - Garrido, H.

AU - Sheppard, B.

AU - Umaña, P.

AU - Murphy, D.L.

AU - Wendland, J.R.

AU - Veenstra-Vanderweele, J.

AU - Denys, D.

AU - Blom, R.

AU - Deforce, D.

AU - van Nieuwerburgh, F.

AU - Westenberg, H.G.

AU - Walitza, S.

AU - Egberts, K.

AU - Renner, T.

AU - Miguel, E.C.

AU - Cappi, C.

AU - Hounie, A.G.

AU - Conceição do Rosário, M.

AU - Sampaio, A.S.

AU - Vallada, H.

AU - Nicolini, H.

AU - Lanzagorta, N.

AU - Camarena, B.

AU - Delorme, R.

AU - Leboyer, M.

AU - Pato, C.N.

AU - Pato, M.T.

AU - Voyiaziakis, E.

AU - Heutink, P.

AU - Cath, D.C.

AU - Posthuma, D.

AU - Smit, J.H.

AU - Samuels, J.

AU - Bienvenu, O.J.

AU - Cullen, B.

AU - Fyer, A.J.

AU - Grados, M.A.

AU - Greenberg, B.D.

AU - McCracken, J.T.

AU - Riddle, M.A.

AU - Wang, Y.

AU - Coric, V.

AU - Leckman, J.F.

AU - Bloch, M.

AU - Pittenger, C.

AU - Eapen, V.

AU - Black, D.W.

AU - Ophoff, R.A.

AU - Strengman, E.

AU - Cusi, D.

AU - Turiel, M.

AU - Frau, F.

AU - Macciardi, F.

AU - Gibbs, J.R.

AU - Cookson, M.R.

AU - Singleton, A.

AU - Hardy, J.

AU - Crenshaw, A.T.

AU - Parkin, M.A.

AU - Mirel, D.B.

AU - Conti, D.V.

AU - Purcell, S.

AU - Nestadt, G.

AU - Hanna, G.L.

AU - Jenike, M.A.

AU - Knowles, J.A.

AU - Cox, N.

AU - Pauls, D.L.

N1 - North American Brain Expression Consortium; UK Brain Expression Database

PY - 2013

Y1 - 2013

N2 - Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469 410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10

AB - Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469 410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10

U2 - 10.1038/mp.2012.85

DO - 10.1038/mp.2012.85

M3 - Article

SN - 1359-4184

VL - 18

SP - 788

EP - 798

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 7

ER -

Genome-wide association study of obsessive-compulsive disorder

Abstract

Bibliographical note

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

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