Abstract
Little is known about genes regulating male puberty. Further, while many identified pubertal timing 1variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9×10-
Original language | English |
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Pages (from-to) | 4452-4464 |
Number of pages | 13 |
Journal | Human Molecular Genetics |
Volume | 23 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2014 |
Cohort Studies
- Netherlands Twin Register (NTR)