Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

D.L. Cousminer; E. Stergiakouli; D.J. Berry; W. Ang; M.M. Blokhuis; A. Körner; N. Siitonen; I. Ntalla; M. Marinelli; J.R.B. Perry; J. Kettunen; R. Jansen; I. Surakka; N.J. Timpson; S. Ring; G. McMahon; C. Power; C. Wang; M. Kähönen; J. Viikari; T. Lehtimäki; C.M. Middeldorp; C.E.M. van Beijsterveldt; H.E. Hulshoff Pol; R.M. Neef; S. Weise; K. Pahkala; H. Niinikoski; E. Zeggini; K. Panoutsopoulou; M. Bustamante; B.W.J.H. Penninx; J. Murabito; M. Torrent; G.V. Dedoussis; W. Kiess; D.I. Boomsma; C.E. Pennell; O.T. Raitakari; E. Hyppönen; G. Davey Smith; S. Ripatti; M.I. McCarthy; E. Widen

doi:10.1093/hmg/ddu150

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

D.L. Cousminer
, E. Stergiakouli
, D.J. Berry
, W. Ang
, M.M. Blokhuis
, A. Körner
, N. Siitonen
, I. Ntalla
, M. Marinelli
, J.R.B. Perry
, J. Kettunen
, R. Jansen
, I. Surakka
, N.J. Timpson
, S. Ring
, G. McMahon
, C. Power
, C. Wang
, M. Kähönen
, J. Viikari

T. Lehtimäki, C.M. Middeldorp, C.E.M. van Beijsterveldt, H.E. Hulshoff Pol, R.M. Neef, S. Weise, K. Pahkala, H. Niinikoski, E. Zeggini, K. Panoutsopoulou, M. Bustamante, B.W.J.H. Penninx, J. Murabito, M. Torrent, G.V. Dedoussis, W. Kiess, D.I. Boomsma, C.E. Pennell, O.T. Raitakari, E. Hyppönen, G. Davey Smith, S. Ripatti, M.I. McCarthy, E. Widen

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Little is known about genes regulating male puberty. Further, while many identified pubertal timing 1variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9×10-

Original language	English
Pages (from-to)	4452-4464
Number of pages	13
Journal	Human Molecular Genetics
Volume	23
Issue number	16
DOIs	https://doi.org/10.1093/hmg/ddu150
Publication status	Published - 2014

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SDG 3 Good Health and Well-being

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Cousminer, D. L., Stergiakouli, E., Berry, D. J., Ang, W., Blokhuis, M. M., Körner, A., Siitonen, N., Ntalla, I., Marinelli, M., Perry, J. R. B., Kettunen, J., Jansen, R., Surakka, I., Timpson, N. J., Ring, S., McMahon, G., Power, C., Wang, C., Kähönen, M., ... Widen, E. (2014). Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human Molecular Genetics, 23(16), 4452-4464. https://doi.org/10.1093/hmg/ddu150

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title = "Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty",

abstract = "Little is known about genes regulating male puberty. Further, while many identified pubertal timing 1variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9×10-",

author = "D.L. Cousminer and E. Stergiakouli and D.J. Berry and W. Ang and M.M. Blokhuis and A. K{\"o}rner and N. Siitonen and I. Ntalla and M. Marinelli and J.R.B. Perry and J. Kettunen and R. Jansen and I. Surakka and N.J. Timpson and S. Ring and G. McMahon and C. Power and C. Wang and M. K{\"a}h{\"o}nen and J. Viikari and T. Lehtim{\"a}ki and C.M. Middeldorp and \{van Beijsterveldt\}, C.E.M. and \{Hulshoff Pol\}, H.E. and R.M. Neef and S. Weise and K. Pahkala and H. Niinikoski and E. Zeggini and K. Panoutsopoulou and M. Bustamante and B.W.J.H. Penninx and J. Murabito and M. Torrent and G.V. Dedoussis and W. Kiess and D.I. Boomsma and C.E. Pennell and O.T. Raitakari and E. Hypp{\"o}nen and \{Davey Smith\}, G. and S. Ripatti and M.I. McCarthy and E. Widen",

year = "2014",

doi = "10.1093/hmg/ddu150",

language = "English",

volume = "23",

pages = "4452--4464",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

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Cousminer, DL, Stergiakouli, E, Berry, DJ, Ang, W, Blokhuis, MM, Körner, A, Siitonen, N, Ntalla, I, Marinelli, M, Perry, JRB, Kettunen, J, Jansen, R, Surakka, I, Timpson, NJ, Ring, S, McMahon, G, Power, C, Wang, C, Kähönen, M, Viikari, J, Lehtimäki, T, Middeldorp, CM, van Beijsterveldt, CEM, Hulshoff Pol, HE, Neef, RM, Weise, S, Pahkala, K, Niinikoski, H, Zeggini, E, Panoutsopoulou, K, Bustamante, M, Penninx, BWJH, Murabito, J, Torrent, M, Dedoussis, GV, Kiess, W, Boomsma, DI, Pennell, CE, Raitakari, OT, Hyppönen, E, Davey Smith, G, Ripatti, S, McCarthy, MI & Widen, E 2014, 'Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty', Human Molecular Genetics, vol. 23, no. 16, pp. 4452-4464. https://doi.org/10.1093/hmg/ddu150

TY - JOUR

T1 - Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

AU - Cousminer, D.L.

AU - Stergiakouli, E.

AU - Berry, D.J.

AU - Ang, W.

AU - Blokhuis, M.M.

AU - Körner, A.

AU - Siitonen, N.

AU - Ntalla, I.

AU - Marinelli, M.

AU - Perry, J.R.B.

AU - Kettunen, J.

AU - Jansen, R.

AU - Surakka, I.

AU - Timpson, N.J.

AU - Ring, S.

AU - McMahon, G.

AU - Power, C.

AU - Wang, C.

AU - Kähönen, M.

AU - Viikari, J.

AU - Lehtimäki, T.

AU - Middeldorp, C.M.

AU - van Beijsterveldt, C.E.M.

AU - Hulshoff Pol, H.E.

AU - Neef, R.M.

AU - Weise, S.

AU - Pahkala, K.

AU - Niinikoski, H.

AU - Zeggini, E.

AU - Panoutsopoulou, K.

AU - Bustamante, M.

AU - Penninx, B.W.J.H.

AU - Murabito, J.

AU - Torrent, M.

AU - Dedoussis, G.V.

AU - Kiess, W.

AU - Boomsma, D.I.

AU - Pennell, C.E.

AU - Raitakari, O.T.

AU - Hyppönen, E.

AU - Davey Smith, G.

AU - Ripatti, S.

AU - McCarthy, M.I.

AU - Widen, E.

PY - 2014

Y1 - 2014

N2 - Little is known about genes regulating male puberty. Further, while many identified pubertal timing 1variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9×10-

AB - Little is known about genes regulating male puberty. Further, while many identified pubertal timing 1variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9×10-

U2 - 10.1093/hmg/ddu150

DO - 10.1093/hmg/ddu150

M3 - Article

SN - 0964-6906

VL - 23

SP - 4452

EP - 4464

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 16

ER -

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

Abstract

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