Genome-wide Association Study of Smoking Initiation and Current Smoking

J.M. Vink, A.B. Smit, E.J.C. de Geus, P.F. Sullivan, G. Willemsen, J.J. Hottenga, J.H. Smit, W.J.G. Hoogendijk, F. G. Zitman, L. Peltonen, J. Kaprio, N.L. Pedersen, P.K.E. Magnusson, T.D. Spector, K.O. Kyvik, K.I. Morley, A.C. Heath, N.G. Martin, R.G.J. Westendorp, P.E. Slagboom & 8 others H. Tiemeier, A. Hofman, A.G. Uitterlinden, Y.S. Aulchenko, N. Amin, C. van Duijn, B.W.J.H. Penninx, D.I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. © 2009 The American Society of Human Genetics.
Original languageEnglish
Pages (from-to)367-379
JournalAmerican Journal of Human Genetics
Volume84
Issue number3
DOIs
Publication statusPublished - 2009

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Genome-Wide Association Study
Smoking
Excitatory Amino Acid Transporter 2
Genes
Proteins
Glutamate Receptors
Cell Adhesion Molecules
Receptor Protein-Tyrosine Kinases
Genome

Cite this

Vink, J.M. ; Smit, A.B. ; de Geus, E.J.C. ; Sullivan, P.F. ; Willemsen, G. ; Hottenga, J.J. ; Smit, J.H. ; Hoogendijk, W.J.G. ; Zitman, F. G. ; Peltonen, L. ; Kaprio, J. ; Pedersen, N.L. ; Magnusson, P.K.E. ; Spector, T.D. ; Kyvik, K.O. ; Morley, K.I. ; Heath, A.C. ; Martin, N.G. ; Westendorp, R.G.J. ; Slagboom, P.E. ; Tiemeier, H. ; Hofman, A. ; Uitterlinden, A.G. ; Aulchenko, Y.S. ; Amin, N. ; van Duijn, C. ; Penninx, B.W.J.H. ; Boomsma, D.I. / Genome-wide Association Study of Smoking Initiation and Current Smoking. In: American Journal of Human Genetics. 2009 ; Vol. 84, No. 3. pp. 367-379.
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abstract = "For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. {\circledC} 2009 The American Society of Human Genetics.",
author = "J.M. Vink and A.B. Smit and {de Geus}, E.J.C. and P.F. Sullivan and G. Willemsen and J.J. Hottenga and J.H. Smit and W.J.G. Hoogendijk and Zitman, {F. G.} and L. Peltonen and J. Kaprio and N.L. Pedersen and P.K.E. Magnusson and T.D. Spector and K.O. Kyvik and K.I. Morley and A.C. Heath and N.G. Martin and R.G.J. Westendorp and P.E. Slagboom and H. Tiemeier and A. Hofman and A.G. Uitterlinden and Y.S. Aulchenko and N. Amin and {van Duijn}, C. and B.W.J.H. Penninx and D.I. Boomsma",
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Vink, JM, Smit, AB, de Geus, EJC, Sullivan, PF, Willemsen, G, Hottenga, JJ, Smit, JH, Hoogendijk, WJG, Zitman, FG, Peltonen, L, Kaprio, J, Pedersen, NL, Magnusson, PKE, Spector, TD, Kyvik, KO, Morley, KI, Heath, AC, Martin, NG, Westendorp, RGJ, Slagboom, PE, Tiemeier, H, Hofman, A, Uitterlinden, AG, Aulchenko, YS, Amin, N, van Duijn, C, Penninx, BWJH & Boomsma, DI 2009, 'Genome-wide Association Study of Smoking Initiation and Current Smoking' American Journal of Human Genetics, vol. 84, no. 3, pp. 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

Genome-wide Association Study of Smoking Initiation and Current Smoking. / Vink, J.M.; Smit, A.B.; de Geus, E.J.C.; Sullivan, P.F.; Willemsen, G.; Hottenga, J.J.; Smit, J.H.; Hoogendijk, W.J.G.; Zitman, F. G.; Peltonen, L.; Kaprio, J.; Pedersen, N.L.; Magnusson, P.K.E.; Spector, T.D.; Kyvik, K.O.; Morley, K.I.; Heath, A.C.; Martin, N.G.; Westendorp, R.G.J.; Slagboom, P.E.; Tiemeier, H.; Hofman, A.; Uitterlinden, A.G.; Aulchenko, Y.S.; Amin, N.; van Duijn, C.; Penninx, B.W.J.H.; Boomsma, D.I.

In: American Journal of Human Genetics, Vol. 84, No. 3, 2009, p. 367-379.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Genome-wide Association Study of Smoking Initiation and Current Smoking

AU - Vink, J.M.

AU - Smit, A.B.

AU - de Geus, E.J.C.

AU - Sullivan, P.F.

AU - Willemsen, G.

AU - Hottenga, J.J.

AU - Smit, J.H.

AU - Hoogendijk, W.J.G.

AU - Zitman, F. G.

AU - Peltonen, L.

AU - Kaprio, J.

AU - Pedersen, N.L.

AU - Magnusson, P.K.E.

AU - Spector, T.D.

AU - Kyvik, K.O.

AU - Morley, K.I.

AU - Heath, A.C.

AU - Martin, N.G.

AU - Westendorp, R.G.J.

AU - Slagboom, P.E.

AU - Tiemeier, H.

AU - Hofman, A.

AU - Uitterlinden, A.G.

AU - Aulchenko, Y.S.

AU - Amin, N.

AU - van Duijn, C.

AU - Penninx, B.W.J.H.

AU - Boomsma, D.I.

PY - 2009

Y1 - 2009

N2 - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. © 2009 The American Society of Human Genetics.

AB - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. © 2009 The American Society of Human Genetics.

U2 - 10.1016/j.ajhg.2009.02.001

DO - 10.1016/j.ajhg.2009.02.001

M3 - Article

VL - 84

SP - 367

EP - 379

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 3

ER -