Genome-wide Association Study of Smoking Initiation and Current Smoking

J.M. Vink; A.B. Smit; E.J.C. de Geus; P.F. Sullivan; G. Willemsen; J.J. Hottenga; J.H. Smit; W.J.G. Hoogendijk; F. G. Zitman; L. Peltonen; J. Kaprio; N.L. Pedersen; P.K.E. Magnusson; T.D. Spector; K.O. Kyvik; K.I. Morley; A.C. Heath; N.G. Martin; R.G.J. Westendorp; P.E. Slagboom; H. Tiemeier; A. Hofman; A.G. Uitterlinden; Y.S. Aulchenko; N. Amin; C. van Duijn; B.W.J.H. Penninx; D.I. Boomsma

doi:10.1016/j.ajhg.2009.02.001

Genome-wide Association Study of Smoking Initiation and Current Smoking

J.M. Vink
, A.B. Smit
, E.J.C. de Geus
, P.F. Sullivan
, G. Willemsen
, J.J. Hottenga
, J.H. Smit
, W.J.G. Hoogendijk
, F. G. Zitman
, L. Peltonen
, J. Kaprio
, N.L. Pedersen
, P.K.E. Magnusson
, T.D. Spector
, K.O. Kyvik
, K.I. Morley
, A.C. Heath
, N.G. Martin
, R.G.J. Westendorp
, P.E. Slagboom

H. Tiemeier, A. Hofman, A.G. Uitterlinden, Y.S. Aulchenko, N. Amin, C. van Duijn, B.W.J.H. Penninx, D.I. Boomsma

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. © 2009 The American Society of Human Genetics.

Original language	English
Pages (from-to)	367-379
Journal	American Journal of Human Genetics
Volume	84
Issue number	3
DOIs	https://doi.org/10.1016/j.ajhg.2009.02.001
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

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10.1016/j.ajhg.2009.02.001

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR-publicaties_2009/Vink_AJHG_2009.pdf

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Vink, J. M., Smit, A. B., de Geus, E. J. C., Sullivan, P. F., Willemsen, G., Hottenga, J. J., Smit, J. H., Hoogendijk, W. J. G., Zitman, F. G., Peltonen, L., Kaprio, J., Pedersen, N. L., Magnusson, P. K. E., Spector, T. D., Kyvik, K. O., Morley, K. I., Heath, A. C., Martin, N. G., Westendorp, R. G. J., ... Boomsma, D. I. (2009). Genome-wide Association Study of Smoking Initiation and Current Smoking. American Journal of Human Genetics, 84(3), 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

@article{7a18145c5f9e4640a1a49cc0b14aef4a,

title = "Genome-wide Association Study of Smoking Initiation and Current Smoking",

abstract = "For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. {\textcopyright} 2009 The American Society of Human Genetics.",

author = "J.M. Vink and A.B. Smit and \{de Geus\}, E.J.C. and P.F. Sullivan and G. Willemsen and J.J. Hottenga and J.H. Smit and W.J.G. Hoogendijk and Zitman, \{F. G.\} and L. Peltonen and J. Kaprio and N.L. Pedersen and P.K.E. Magnusson and T.D. Spector and K.O. Kyvik and K.I. Morley and A.C. Heath and N.G. Martin and R.G.J. Westendorp and P.E. Slagboom and H. Tiemeier and A. Hofman and A.G. Uitterlinden and Y.S. Aulchenko and N. Amin and \{van Duijn\}, C. and B.W.J.H. Penninx and D.I. Boomsma",

year = "2009",

doi = "10.1016/j.ajhg.2009.02.001",

language = "English",

volume = "84",

pages = "367--379",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "3",

}

Vink, JM, Smit, AB , de Geus, EJC, Sullivan, PF, Willemsen, G, Hottenga, JJ, Smit, JH, Hoogendijk, WJG, Zitman, FG, Peltonen, L, Kaprio, J, Pedersen, NL, Magnusson, PKE, Spector, TD, Kyvik, KO, Morley, KI, Heath, AC, Martin, NG, Westendorp, RGJ, Slagboom, PE, Tiemeier, H, Hofman, A, Uitterlinden, AG, Aulchenko, YS, Amin, N, van Duijn, C, Penninx, BWJH & Boomsma, DI 2009, 'Genome-wide Association Study of Smoking Initiation and Current Smoking', American Journal of Human Genetics, vol. 84, no. 3, pp. 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

TY - JOUR

T1 - Genome-wide Association Study of Smoking Initiation and Current Smoking

AU - Vink, J.M.

AU - Smit, A.B.

AU - de Geus, E.J.C.

AU - Sullivan, P.F.

AU - Willemsen, G.

AU - Hottenga, J.J.

AU - Smit, J.H.

AU - Hoogendijk, W.J.G.

AU - Zitman, F. G.

AU - Peltonen, L.

AU - Kaprio, J.

AU - Pedersen, N.L.

AU - Magnusson, P.K.E.

AU - Spector, T.D.

AU - Kyvik, K.O.

AU - Morley, K.I.

AU - Heath, A.C.

AU - Martin, N.G.

AU - Westendorp, R.G.J.

AU - Slagboom, P.E.

AU - Tiemeier, H.

AU - Hofman, A.

AU - Uitterlinden, A.G.

AU - Aulchenko, Y.S.

AU - Amin, N.

AU - van Duijn, C.

AU - Penninx, B.W.J.H.

AU - Boomsma, D.I.

PY - 2009

Y1 - 2009

N2 - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. © 2009 The American Society of Human Genetics.

AB - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior. © 2009 The American Society of Human Genetics.

U2 - 10.1016/j.ajhg.2009.02.001

DO - 10.1016/j.ajhg.2009.02.001

M3 - Article

SN - 0002-9297

VL - 84

SP - 367

EP - 379

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Genome-wide Association Study of Smoking Initiation and Current Smoking

Abstract

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