Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

Funding

We gratefully thank all research participants, as this work would not have been possible without their contributions. Relevant funding sources for the FinnGen, UKB and All of Us datasets are presented in the Supplementary Note. S.J.J. received research support through the Junior Clinical Scientist Fellowship from the Dutch Heart Foundation (03-007-2022-0035), as well as a doctoral fellowship from the Amsterdam UMC. J.T.R. was supported by a research grant from the Aarne Koskelo Foundation. S.K. was supported by the Walter Benjamin Fellowship from the Deutsche Forschungsgemeinschaft (521832260). L.F.J.M.W. was supported by the Amsterdam UMC YTF, Dutch Heart Foundation Student Grant and the AFIP foundation. P.T.E. was supported by funding from the National Institutes of Health (1RO1HL092577, 1R01HL157635, 5R01HL139731), by a grant from the American Heart Association (18SFRN34110082) and from the European Union (MAESTRIA 965286). This work was further supported by a grant from the National Institutes of Health (1K08HL153937) and a grant from the American Heart Association (862032) to K.G.A. C.R.B. was supported by funding from the Dutch Heart Foundation (CVON 2018-30 PREDICT2) and the Pathfinder Cardiogenomics programme of the European Innovation Council of the European Union (DCM-NEXT). A.A.M., D.R.K. and Y.M.P. were supported by funding from the PSIDER programme of the Netherlands Organisation for Health Research and Development (ZonMW; project 40-46800-98-018). T.N. was supported by grants from the Sigrid Jus\u00E9lius Foundation, the Finnish Foundation for Cardiovascular Research and the Finnish Research Council (grants 321351 and 354447). This work was supported by a grant from the GENMED Laboratory of Excellence on Medical Genomics (ANR-10-LABX-0013)\u2014a research program managed by the National Research Agency (ANR) as part of the French Investment for the Future; Aviesan-ITMO Genetique-Genomique-Bioinformatique (ResDiCard: Resolving diagnostic deadlock in cardiomyopathies) and the Soci\u00E9t\u00E9 Fran\u00E7aise de Cardiologie/F\u00E9d\u00E9ration Fran\u00E7aise de Cardiologie; the SFB-TR19 registry was supported by the Deutsche Forschungsgemeinschaft (DFG). The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net of the University of Greifswald, Germany, funded by the Federal Ministry of Education and Research (grants 01ZZ9603, 01ZZ0103, and 01ZZ0403); the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg-West Pomerania; and grants from the German Center for Cardiovascular Research (DZHK). The KORA study was initiated and financed by the Helmholtz Zentrum M\u00FCnchen\u2014German Research Center for Environmental Health, funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. KORA research was supported at the Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universit\u00E4t, as part of LMUinnovativ. D.A.T. is supported by the \u2018EPIDEMIOM-VTE\u2019 Senior Chair from the Initiative of Excellence of the University of Bordeaux. This research is based on data from the Million Veteran Program, Office of Research and Development, Veterans Health Administration, and was supported by award I01-BX003362 to P.T. and K.-M.C. This publication does not represent the views of the Department of Veteran Affairs or the United States Government. This work was also supported by the Sir Jules Thorn Charitable Trust (21JTA), Medical Research Council (UK), British Heart Foundation (RE/18/4/34215, SP/17/11/32885), the NIHR Imperial College B\u00AD\u00ADiomedical Research Centre, Pathfinder Cardiogenomics programme of the European Innovation Council of the European Union (DCM-NEXT) (101115416) to J.S.W. We gratefully thank all research participants, as this work would not have been possible without their contributions. Relevant funding sources for the FinnGen, UKB and All of Us datasets are presented in the Supplementary . S.J.J. received research support through the Junior Clinical Scientist Fellowship from the Dutch Heart Foundation (03-007-2022-0035), as well as a doctoral fellowship from the Amsterdam UMC. J.T.R. was supported by a research grant from the Aarne Koskelo Foundation. S.K. was supported by the Walter Benjamin Fellowship from the Deutsche Forschungsgemeinschaft (521832260). L.F.J.M.W. was supported by the Amsterdam UMC YTF, Dutch Heart Foundation Student Grant and the AFIP foundation. P.T.E. was supported by funding from the National Institutes of Health (1RO1HL092577, 1R01HL157635, 5R01HL139731), by a grant from the American Heart Association (18SFRN34110082) and from the European Union (MAESTRIA 965286). This work was further supported by a grant from the National Institutes of Health (1K08HL153937) and a grant from the American Heart Association (862032) to K.G.A. C.R.B. was supported by funding from the Dutch Heart Foundation (CVON 2018-30 PREDICT2) and the Pathfinder Cardiogenomics programme of the European Innovation Council of the European Union (DCM-NEXT). A.A.M., D.R.K. and Y.M.P. were supported by funding from the PSIDER programme of the Netherlands Organisation for Health Research and Development (ZonMW; project 40-46800-98-018). T.N. was supported by grants from the Sigrid Jus\u00E9lius Foundation, the Finnish Foundation for Cardiovascular Research and the Finnish Research Council (grants 321351 and 354447). This work was supported by a grant from the GENMED Laboratory of Excellence on Medical Genomics (ANR-10-LABX-0013)\u2014a research program managed by the National Research Agency (ANR) as part of the French Investment for the Future; Aviesan-ITMO Genetique-Genomique-Bioinformatique (ResDiCard: Resolving diagnostic deadlock in cardiomyopathies) and the Soci\u00E9t\u00E9 Fran\u00E7aise de Cardiologie/F\u00E9d\u00E9ration Fran\u00E7aise de Cardiologie; the SFB-TR19 registry was supported by the Deutsche Forschungsgemeinschaft (DFG). The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net of the University of Greifswald, Germany, funded by the Federal Ministry of Education and Research (grants 01ZZ9603, 01ZZ0103, and 01ZZ0403); the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg-West Pomerania; and grants from the German Center for Cardiovascular Research (DZHK). The KORA study was initiated and financed by the Helmholtz Zentrum M\u00FCnchen\u2014German Research Center for Environmental Health, funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. KORA research was supported at the Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universit\u00E4t, as part of LMUinnovativ. D.A.T. is supported by the \u2018EPIDEMIOM-VTE\u2019 Senior Chair from the Initiative of Excellence of the University of Bordeaux. This research is based on data from the Million Veteran Program, Office of Research and Development, Veterans Health Administration, and was supported by award I01-BX003362 to P.T. and K.-M.C. This publication does not represent the views of the Department of Veteran Affairs or the United States Government. This work was also supported by the Sir Jules Thorn Charitable Trust (21JTA), Medical Research Council (UK), British Heart Foundation (RE/18/4/34215, SP/17/11/32885), the NIHR Imperial College Biomedical Research Centre, Pathfinder Cardiogenomics programme of the European Innovation Council of the European Union (DCM-NEXT) (101115416) to J.S.W.