Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States

M. Luciano; J.E. Huffman; A. Arias-Vasquez; A.A.E. Vinkhuyzen; C.M. Middeldorp; I. Giegling; A. Payton; G.E. Davies; L. Zgaga; J.G. Janzing; X.Y. Ke; T. Galesloot; A. M. Hartmann; W. Ollier; A. Tenesa; C. Hayward; M. Verhagen; G.W. Montgomery; J.J. Hottenga; B. Konte; J.M. Starr; V. Vitart; P.E. Vos; P.A.F. Madden; G. Willemsen; H. Konnerth; M.A. Horan; D.J. Porteous; H. Campbell; S.H. Vermeulen; A.C. Heath; A. Wright; O. Polasek; S.B. Kovacevic; N. Hastie; B. Franke; D.I. Boomsma; N.G. Martin; D. Rujescu; J.F. Wilson; J. Buitelaar; N. Pendleton; I. Rudan; I.J. Deary

doi:10.1002/ajmg.b.32072

Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States

M. Luciano, J.E. Huffman, A. Arias-Vasquez, A.A.E. Vinkhuyzen, C.M. Middeldorp, I. Giegling, A. Payton, G.E. Davies, L. Zgaga, J.G. Janzing, X.Y. Ke, T. Galesloot, A. M. Hartmann, W. Ollier, A. Tenesa, C. Hayward, M. Verhagen, G.W. Montgomery, J.J. Hottenga, B. KonteJ.M. Starr, V. Vitart, P.E. Vos, P.A.F. Madden, G. Willemsen, H. Konnerth, M.A. Horan, D.J. Porteous, H. Campbell, S.H. Vermeulen, A.C. Heath, A. Wright, O. Polasek, S.B. Kovacevic, N. Hastie, B. Franke, D.I. Boomsma, N.G. Martin, D. Rujescu, J.F. Wilson, J. Buitelaar, N. Pendleton, I. Rudan, I.J. Deary

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n=6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n=527-6,032). Suggestive association (P=8×10

Original language	English
Pages (from-to)	684-695
Journal	American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume	159B
Issue number	6
DOIs	https://doi.org/10.1002/ajmg.b.32072
Publication status	Published - 2012

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Luciano, M., Huffman, J. E., Arias-Vasquez, A., Vinkhuyzen, A. A. E., Middeldorp, C. M., Giegling, I., Payton, A., Davies, G. E., Zgaga, L., Janzing, J. G., Ke, X. Y., Galesloot, T., Hartmann, A. M., Ollier, W., Tenesa, A., Hayward, C., Verhagen, M., Montgomery, G. W., Hottenga, J. J., ... Deary, I. J. (2012). Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(6), 684-695. https://doi.org/10.1002/ajmg.b.32072

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title = "Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States",

abstract = "Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n=6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n=527-6,032). Suggestive association (P=8×10",

author = "M. Luciano and J.E. Huffman and A. Arias-Vasquez and A.A.E. Vinkhuyzen and C.M. Middeldorp and I. Giegling and A. Payton and G.E. Davies and L. Zgaga and J.G. Janzing and X.Y. Ke and T. Galesloot and Hartmann, {A. M.} and W. Ollier and A. Tenesa and C. Hayward and M. Verhagen and G.W. Montgomery and J.J. Hottenga and B. Konte and J.M. Starr and V. Vitart and P.E. Vos and P.A.F. Madden and G. Willemsen and H. Konnerth and M.A. Horan and D.J. Porteous and H. Campbell and S.H. Vermeulen and A.C. Heath and A. Wright and O. Polasek and S.B. Kovacevic and N. Hastie and B. Franke and D.I. Boomsma and N.G. Martin and D. Rujescu and J.F. Wilson and J. Buitelaar and N. Pendleton and I. Rudan and I.J. Deary",

year = "2012",

doi = "10.1002/ajmg.b.32072",

language = "English",

volume = "159B",

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journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics",

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Luciano, M, Huffman, JE, Arias-Vasquez, A, Vinkhuyzen, AAE, Middeldorp, CM, Giegling, I, Payton, A, Davies, GE, Zgaga, L, Janzing, JG, Ke, XY, Galesloot, T, Hartmann, AM, Ollier, W, Tenesa, A, Hayward, C, Verhagen, M, Montgomery, GW, Hottenga, JJ, Konte, B, Starr, JM, Vitart, V, Vos, PE, Madden, PAF, Willemsen, G, Konnerth, H, Horan, MA, Porteous, DJ, Campbell, H, Vermeulen, SH, Heath, AC, Wright, A, Polasek, O, Kovacevic, SB, Hastie, N, Franke, B, Boomsma, DI, Martin, NG, Rujescu, D, Wilson, JF, Buitelaar, J, Pendleton, N, Rudan, I & Deary, IJ 2012, 'Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 159B, no. 6, pp. 684-695. https://doi.org/10.1002/ajmg.b.32072

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T1 - Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States

AU - Luciano, M.

AU - Huffman, J.E.

AU - Arias-Vasquez, A.

AU - Vinkhuyzen, A.A.E.

AU - Middeldorp, C.M.

AU - Giegling, I.

AU - Payton, A.

AU - Davies, G.E.

AU - Zgaga, L.

AU - Janzing, J.G.

AU - Ke, X.Y.

AU - Galesloot, T.

AU - Hartmann, A. M.

AU - Ollier, W.

AU - Tenesa, A.

AU - Hayward, C.

AU - Verhagen, M.

AU - Montgomery, G.W.

AU - Hottenga, J.J.

AU - Konte, B.

AU - Starr, J.M.

AU - Vitart, V.

AU - Vos, P.E.

AU - Madden, P.A.F.

AU - Willemsen, G.

AU - Konnerth, H.

AU - Horan, M.A.

AU - Porteous, D.J.

AU - Campbell, H.

AU - Vermeulen, S.H.

AU - Heath, A.C.

AU - Wright, A.

AU - Polasek, O.

AU - Kovacevic, S.B.

AU - Hastie, N.

AU - Franke, B.

AU - Boomsma, D.I.

AU - Martin, N.G.

AU - Rujescu, D.

AU - Wilson, J.F.

AU - Buitelaar, J.

AU - Pendleton, N.

AU - Rudan, I.

AU - Deary, I.J.

PY - 2012

Y1 - 2012

N2 - Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n=6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n=527-6,032). Suggestive association (P=8×10

AB - Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n=6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n=527-6,032). Suggestive association (P=8×10

U2 - 10.1002/ajmg.b.32072

DO - 10.1002/ajmg.b.32072

M3 - Article

SN - 1552-4841

VL - 159B

SP - 684

EP - 695

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

IS - 6

ER -

Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States

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